PMID- 36820096
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240426
IS  - 2589-5370 (Electronic)
IS  - 2589-5370 (Linking)
VI  - 57
DP  - 2023 Mar
TI  - Air pollution and decreased bone mineral density among Women's Health Initiative 
      participants.
PG  - 101864
LID - 10.1016/j.eclinm.2023.101864 [doi]
LID - 101864
AB  - BACKGROUND: Osteoporosis heavily affects postmenopausal women and is influenced 
      by environmental exposures. Determining the impact of criteria air pollutants and 
      their mixtures on bone mineral density (BMD) in postmenopausal women is an urgent 
      priority. METHODS: We conducted a prospective observational study using data from 
      the ethnically diverse Women's Health Initiative Study (WHI) (enrollment, 
      September 1994-December 1998; data analysis, January 2020 to August 2022). We 
      used log-normal, ordinary kriging to estimate daily mean concentrations of 
      PM(10), NO, NO(2), and SO(2) at participants' geocoded addresses (1-, 3-, and 
      5-year averages before BMD assessments). We measured whole-body, total hip, 
      femoral neck, and lumbar spine BMD at enrollment and follow-up (Y1, Y3, Y6) via 
      dual-energy X-ray absorptiometry. We estimated associations using multivariable 
      linear and linear mixed-effects models and mixture effects using Bayesian kernel 
      machine regression (BKMR) models. FINDINGS: In cross-sectional and longitudinal 
      analyses, mean PM(10), NO, NO(2), and SO(2) averaged over 1, 3, and 5 years 
      before the visit were negatively associated with whole-body, total hip, femoral 
      neck, and lumbar spine BMD. For example, lumbar spine BMD decreased 0.026 (95% 
      CI: 0.016, 0.036) g/cm(2)/year per a 10% increase in 3-year mean NO(2) 
      concentration. BKMR suggested that nitrogen oxides exposure was inversely 
      associated with whole-body and lumbar spine BMD. INTERPRETATION: In this cohort 
      study, higher levels of air pollutants were associated with bone damage, 
      particularly on lumbar spine, among postmenopausal women. These findings 
      highlight nitrogen oxides exposure as a leading contributor to bone loss in 
      postmenopausal women, expanding previous findings of air pollution-related bone 
      damage. FUNDING: US National Institutes of Health.
CI  - (c) 2023 The Author(s).
FAU - Prada, Diddier
AU  - Prada D
AD  - Department of Environmental Health Science, Mailman School of Public Health, 
      Columbia University, New York, NY, USA.
AD  - Instituto Nacional de Cancerologia - Mexico, Mexico City, Mexico.
FAU - Crandall, Carolyn J
AU  - Crandall CJ
AD  - Division of General Internal Medicine and Health Services Research, David Geffen 
      School of Medicine at University of California, Los Angeles, CA, USA.
FAU - Kupsco, Allison
AU  - Kupsco A
AD  - Department of Environmental Health Science, Mailman School of Public Health, 
      Columbia University, New York, NY, USA.
FAU - Kioumourtzoglou, Marianthi-Anna
AU  - Kioumourtzoglou MA
AD  - Department of Environmental Health Science, Mailman School of Public Health, 
      Columbia University, New York, NY, USA.
FAU - Stewart, James D
AU  - Stewart JD
AD  - Department of Epidemiology, Gillings School of Global Public Health, University 
      of North Carolina, Chapel Hill, NC, USA.
FAU - Liao, Duanping
AU  - Liao D
AD  - Department of Public Health Sciences, Pennsylvania State University College of 
      Medicine, Hershey, PA, USA.
FAU - Yanosky, Jeff D
AU  - Yanosky JD
AD  - Department of Public Health Sciences, Pennsylvania State University College of 
      Medicine, Hershey, PA, USA.
FAU - Ramirez, Andrea
AU  - Ramirez A
AD  - Instituto Nacional de Cancerologia - Mexico, Mexico City, Mexico.
FAU - Wactawski-Wende, Jean
AU  - Wactawski-Wende J
AD  - School of Public Health and Health Professions, University at Buffalo, State 
      University of New York, New York, USA.
FAU - Shen, Yike
AU  - Shen Y
AD  - Department of Environmental Health Science, Mailman School of Public Health, 
      Columbia University, New York, NY, USA.
FAU - Miller, Gary
AU  - Miller G
AD  - Department of Environmental Health Science, Mailman School of Public Health, 
      Columbia University, New York, NY, USA.
FAU - Ionita-Laza, Iuliana
AU  - Ionita-Laza I
AD  - Department of Environmental Health Science, Mailman School of Public Health, 
      Columbia University, New York, NY, USA.
FAU - Whitsel, Eric A
AU  - Whitsel EA
AD  - Department of Epidemiology, Gillings School of Global Public Health and 
      Department of Medicine, School of Medicine, University of North Carolina, Chapel 
      Hill, NC, USA.
FAU - Baccarelli, Andrea A
AU  - Baccarelli AA
AD  - Department of Environmental Health Science, Mailman School of Public Health, 
      Columbia University, New York, NY, USA.
LA  - eng
GR  - U2C ES030163/ES/NIEHS NIH HHS/United States
GR  - 75N92021D00002/HL/NHLBI NIH HHS/United States
GR  - P30 ES010126/ES/NIEHS NIH HHS/United States
GR  - R01 ES020836/ES/NIEHS NIH HHS/United States
GR  - R01 ES029943/ES/NIEHS NIH HHS/United States
GR  - R01 ES032242/ES/NIEHS NIH HHS/United States
GR  - R35 ES031688/ES/NIEHS NIH HHS/United States
GR  - R01 AG058704/AG/NIA NIH HHS/United States
GR  - R01 ES027747/ES/NIEHS NIH HHS/United States
GR  - 75N92021D00004/WH/WHI NIH HHS/United States
GR  - P30 ES009089/ES/NIEHS NIH HHS/United States
GR  - 75N92021D00005/WH/WHI NIH HHS/United States
GR  - R01 ES025225/ES/NIEHS NIH HHS/United States
GR  - 75N92021D00001/HL/NHLBI NIH HHS/United States
GR  - R00 ES030749/ES/NIEHS NIH HHS/United States
GR  - R01 AG069120/AG/NIA NIH HHS/United States
GR  - R01 ES030616/ES/NIEHS NIH HHS/United States
GR  - 75N92021D00003/WH/WHI NIH HHS/United States
GR  - R43 TR000187/TR/NCATS NIH HHS/United States
GR  - R44 TR000187/TR/NCATS NIH HHS/United States
GR  - R01 ES028805/ES/NIEHS NIH HHS/United States
PT  - Journal Article
DEP - 20230215
PL  - England
TA  - EClinicalMedicine
JT  - EClinicalMedicine
JID - 101733727
PMC - PMC9938170
OTO - NOTNLM
OT  - Air pollution
OT  - Bone damage
OT  - Bone mineral density
OT  - Mixtures
OT  - Postmenopause
COIS- Most authors declare that they have no competing interest in any form. JWW 
      declares funding from NHLBI/NIH to support the Women's Health Initiative (JWW is 
      the PI of the northeast WHI regional center), which has occurred since 1993 and 
      will go through 2027. WHI funding for JWW supports support travel to the annual 
      WHI meeting. JWW is dean of the School of Public Health and Health Professions at 
      the University at Buffalo and serves as a board member of several western New 
      York community organizations (unpaid). GM receives royalties for his books (The 
      exposome: a primer [2014]; The exposome: a new paradigm for health and disease 
      [2020], published by Academic Press). GM also receives stipend for serving as 
      Editor of Exposome, published by Oxford University Press. GM also has received 
      honoraria from Kansas University Medical Center (speaker), Mayo Clinic (speaker), 
      Foundation for Gender Specific Medicine (book chapter), AAAS (speaker), Vichy 
      (speaker), University of Colorado (speaker), and the University of Arizona 
      (speaker). When GM speaks at universities in the U.S. the travel is paid by them.
EDAT- 2023/02/24 06:00
MHDA- 2023/02/24 06:01
PMCR- 2023/02/15
CRDT- 2023/02/23 10:32
PHST- 2022/10/31 00:00 [received]
PHST- 2023/01/25 00:00 [revised]
PHST- 2023/01/26 00:00 [accepted]
PHST- 2023/02/23 10:32 [entrez]
PHST- 2023/02/24 06:00 [pubmed]
PHST- 2023/02/24 06:01 [medline]
PHST- 2023/02/15 00:00 [pmc-release]
AID - S2589-5370(23)00041-X [pii]
AID - 101864 [pii]
AID - 10.1016/j.eclinm.2023.101864 [doi]
PST - epublish
SO  - EClinicalMedicine. 2023 Feb 15;57:101864. doi: 10.1016/j.eclinm.2023.101864. 
      eCollection 2023 Mar.