PMID- 36820271
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230224
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 16
DP  - 2023
TI  - Association of Plasma Sex-Related Hormones Levels with Bone Mineral Densities and 
      Risk of Osteoporosis and Osteopenia in Men and Menopausal Women with Type 2 
      Diabetes Mellitus.
PG  - 457-468
LID - 10.2147/DMSO.S401397 [doi]
AB  - OBJECTIVE: This study aimed to examine associations between plasma sex-related 
      hormones with bone mineral density (BMD) and risks of osteoporosis or osteopenia 
      in men and postmenopausal women patients with type 2 diabetes mellitus (T2DM). 
      METHODS: Baseline information on an ongoing cohort of 149 men and 102 
      postmenopausal women with T2DM in Xiamen, China were analyzed. Plasma estradiol 
      (E2), total testosterone (T), follicle-stimulating hormone (FSH), luteinizing 
      hormone (LH) and prolactin (PRL) were measured. BMD of lumbar spine (L2-4), 
      femoral neck (FN) and total hip (TH) were determined by dual-energy X-ray 
      absorptiometry (DXA). Osteoporosis or osteopenia was defined as the minimum 
      T-scores of BMD of these three different sites of -1.0 or below. RESULTS: T2DM 
      patients with osteoporosis/osteopenia (66.4% in men and 79.4% in postmenopausal 
      women), compared to those without, showed significantly decreased level of E2 
      (75.3+/-28.9 vs. 107.8+/-25.9pmol/L and 18.4 (18.4-29.5) vs. 22.8 (18.4-40.5) pmol/L 
      for men and postmenopausal women, respectively, both p-values <0.05), but not 
      other sex-related hormones (including T, FSH, LH, or PRL). For all T2DM patients 
      together and men separately, multivariable linear regression and logistic 
      regression analyses showed that higher E2 levels were significantly associated 
      with higher BMD T-scores in L2-4, FN, TH and minimum of these three different 
      sites, lower 10-year probability of major osteoporotic fractures (MOF) and hip 
      fractures (HFs) estimated by Fracture Risk Assessment Tool score, as well as 
      decreased risk of osteoporosis/osteopenia. As for postmenopausal women T2DM 
      patients, E2 level was positively associated with BMD T-scores in L2-4 and 
      minimum of three different sites but was not independently associated with risk 
      of osteoporosis/osteopenia. CONCLUSION: Higher plasma E2 was significantly 
      associated with increased BMD and lower risk of osteoporosis or osteopenia in 
      T2DM patients, especially for men. Screening of BMD and estradiol levels as well 
      as evaluating risks of osteoporosis/osteopenia are important for T2DM patients.
CI  - (c) 2023 Lu et al.
FAU - Lu, Weihong
AU  - Lu W
AD  - Department of Gynecology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, 
      People's Republic of China.
AD  - Xiamen Clinical Research Center for Cancer Therapy, Xiamen, People's Republic of 
      China.
FAU - Zheng, Silan
AU  - Zheng S
AD  - Department of Endocrinology, Zhongshan Hospital (Xiamen), Fudan University, 
      Xiamen, People's Republic of China.
FAU - Zhou, Jingqi
AU  - Zhou J
AD  - Department of Endocrinology, Zhongshan Hospital (Xiamen), Fudan University, 
      Xiamen, People's Republic of China.
FAU - Huang, Shunfa
AU  - Huang S
AUID- ORCID: 0000-0001-9937-1861
AD  - Department of Radiology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, 
      People's Republic of China.
FAU - Chen, Ning
AU  - Chen N
AD  - Department of Endocrinology, Zhongshan Hospital (Xiamen), Fudan University, 
      Xiamen, People's Republic of China.
FAU - Li, Zhibin
AU  - Li Z
AUID- ORCID: 0000-0001-6642-9780
AD  - Epidemiology Research Unit, Translational Medicine Research Center, The First 
      Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, 
      Xiamen, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20230214
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC9938647
OTO - NOTNLM
OT  - BMD
OT  - bone mineral density
OT  - diabetes
OT  - estradiol
OT  - osteopenia
OT  - osteoporosis
COIS- The authors declare that they have no conflicts of interest in this work.
EDAT- 2023/02/24 06:00
MHDA- 2023/02/24 06:01
PMCR- 2023/02/14
CRDT- 2023/02/23 10:35
PHST- 2022/12/20 00:00 [received]
PHST- 2023/02/02 00:00 [accepted]
PHST- 2023/02/23 10:35 [entrez]
PHST- 2023/02/24 06:00 [pubmed]
PHST- 2023/02/24 06:01 [medline]
PHST- 2023/02/14 00:00 [pmc-release]
AID - 401397 [pii]
AID - 10.2147/DMSO.S401397 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2023 Feb 14;16:457-468. doi: 10.2147/DMSO.S401397. 
      eCollection 2023.