PMID- 36820611
OWN - NLM
STAT- MEDLINE
DCOM- 20230227
LR  - 20231005
IS  - 1525-6049 (Electronic)
IS  - 0886-022X (Print)
IS  - 0886-022X (Linking)
VI  - 45
IP  - 1
DP  - 2023 Dec
TI  - The association of plasma NT-proBNP level and progression of diabetic kidney 
      disease.
PG  - 2158102
LID - 10.1080/0886022X.2022.2158102 [doi]
LID - 2158102
AB  - AIMS: Diabetic kidney disease (DKD) is the most common cause of end-stage kidney 
      disease (ESKD). The identification of risk factors involved in the progression of 
      DKD to ESKD is expected to result in early detection and appropriate intervention 
      and improve prognosis. This study aimed to explore whether plasma N-terminal 
      pro-B-type natriuretic peptide (NT-proBNP) was associated with kidney outcomes in 
      patients with type 2 diabetes mellitus (T2DM) and biopsy-proven DKD. METHODS: 
      Patients with biopsy-proven DKD who were followed up at West China Hospital over 
      12 months were enrolled. The kidney outcome was defined as progression to ESKD. 
      The cutoff value of plasma NT-proBNP concentration was calculated by using 
      receiver operating characteristic (ROC) curve analysis. The influence of 
      NT-proBNP levels on kidney outcome in patients with DKD was assessed using Cox 
      regression analysis. RESULTS: A total of 30 (24.5%) patients reached ESKD during 
      a median follow-up of 24.1 months. The baseline serum NT-proBNP level had a 
      significant correlation with baseline proteinuria, kidney function, glomerular 
      lesions, interstitial fibrosis tubular atrophy (IFTA), and arteriolar hyalinosis. 
      Multivariate Cox regression analysis indicated that increased NT-proBNP level was 
      significantly associated with a higher risk of progression to ESKD (HR 6.43; 95% 
      CI (1.65-25.10, p = 0.007), and each 1 SD increase in LG (NT-proBNP) was also 
      associated with a higher risk (HR 2.43; 95% CI 1.94-5.29, p = 0.047) of an 
      adverse kidney outcome after adjusting for confounding factors. CONCLUSIONS: A 
      higher level of plasma NT-proBNP predicts kidney prognosis in patients with 
      biopsy-proven DKD. This warrants further investigation into the potential 
      mechanisms.
FAU - Zhao, Yuancheng
AU  - Zhao Y
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 
      Sichuan China.
AD  - Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism 
      Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
FAU - Zhao, Lijun
AU  - Zhao L
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 
      Sichuan China.
AD  - Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism 
      Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
FAU - Wang, Yiting
AU  - Wang Y
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 
      Sichuan China.
FAU - Zhang, Junlin
AU  - Zhang J
AD  - Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism 
      Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
FAU - Ren, Honghong
AU  - Ren H
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 
      Sichuan China.
FAU - Zhang, Rui
AU  - Zhang R
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 
      Sichuan China.
FAU - Wu, Yucheng
AU  - Wu Y
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 
      Sichuan China.
FAU - Zou, Yutong
AU  - Zou Y
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 
      Sichuan China.
FAU - Tong, Nanwei
AU  - Tong N
AD  - Division of Endocrinology, West China Hospital of Sichuan University, Chengdu, 
      Sichuan, China.
FAU - Liu, Fang
AU  - Liu F
AUID- ORCID: 0000-0003-1121-3004
AD  - Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 
      Sichuan China.
AD  - Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism 
      Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Ren Fail
JT  - Renal failure
JID - 8701128
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 0 (Peptide Fragments)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - Natriuretic Peptide, Brain
MH  - *Diabetic Nephropathies
MH  - *Diabetes Mellitus, Type 2
MH  - Prognosis
MH  - Peptide Fragments
MH  - *Kidney Failure, Chronic
MH  - Biomarkers
MH  - Disease Progression
PMC - PMC9970255
OTO - NOTNLM
OT  - NT-proBNP
OT  - diabetic kidney disease
OT  - end-stage kidney disease
OT  - type 2 diabetes mellitus
COIS- The authors have no conflicts of interest to disclose, and the results in this 
      paper have not been published previously in whole or in part.
EDAT- 2023/02/24 06:00
MHDA- 2023/03/03 06:00
PMCR- 2023/02/23
CRDT- 2023/02/23 10:41
PHST- 2023/02/23 10:41 [entrez]
PHST- 2023/02/24 06:00 [pubmed]
PHST- 2023/03/03 06:00 [medline]
PHST- 2023/02/23 00:00 [pmc-release]
AID - 2158102 [pii]
AID - 10.1080/0886022X.2022.2158102 [doi]
PST - ppublish
SO  - Ren Fail. 2023 Dec;45(1):2158102. doi: 10.1080/0886022X.2022.2158102.