PMID- 36826287 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230228 IS - 2310-2861 (Electronic) IS - 2310-2861 (Linking) VI - 9 IP - 2 DP - 2023 Feb 1 TI - Engineering Hydrogels for Modulation of Dendritic Cell Function. LID - 10.3390/gels9020116 [doi] LID - 116 AB - Dendritic cells (DCs), the most potent antigen-presenting cells, are necessary for the effective activation of naive T cells. DCs encounter numerous microenvironments with different biophysical properties, such as stiffness and viscoelasticity. Considering the emerging importance of mechanical cues for DC function, it is essential to understand the impacts of these cues on DC function in a physiological or pathological context. Engineered hydrogels have gained interest for the exploration of the impacts of biophysical matrix cues on DC functions, owing to their extracellular-matrix-mimetic properties, such as high water content, a sponge-like pore structure, and tunable mechanical properties. In this review, the introduction of gelation mechanisms of hydrogels is first summarized. Then, recent advances in the substantial effects of developing hydrogels on DC function are highlighted, and the potential molecular mechanisms are subsequently discussed. Finally, persisting questions and future perspectives are presented. FAU - Wu, Cuifang AU - Wu C AD - Key Laboratory of Infectious Immune and Antibody Engineering in University of Guizhou Province, Engineering Research Center of Cellular Immunotherapy of Guizhou Province, School of Basic Medical Sciences/School of Biology and Engineering (School of Modern Industry for Health and Medicine), Guizhou Medical University, Guiyang 550025, China. AD - Immune Cells and Antibody Engineering Research Center in University of Guizhou Province, Key Laboratory of Biology and Medical Engineering, Guizhou Medical University, Guiyang 550025, China. FAU - Teng, Lijing AU - Teng L AD - Key Laboratory of Infectious Immune and Antibody Engineering in University of Guizhou Province, Engineering Research Center of Cellular Immunotherapy of Guizhou Province, School of Basic Medical Sciences/School of Biology and Engineering (School of Modern Industry for Health and Medicine), Guizhou Medical University, Guiyang 550025, China. AD - Immune Cells and Antibody Engineering Research Center in University of Guizhou Province, Key Laboratory of Biology and Medical Engineering, Guizhou Medical University, Guiyang 550025, China. FAU - Wang, Caiyuan AU - Wang C AD - Key Laboratory of Infectious Immune and Antibody Engineering in University of Guizhou Province, Engineering Research Center of Cellular Immunotherapy of Guizhou Province, School of Basic Medical Sciences/School of Biology and Engineering (School of Modern Industry for Health and Medicine), Guizhou Medical University, Guiyang 550025, China. FAU - Qian, Tianbao AU - Qian T AUID- ORCID: 0000-0002-2362-0400 AD - Key Laboratory of Infectious Immune and Antibody Engineering in University of Guizhou Province, Engineering Research Center of Cellular Immunotherapy of Guizhou Province, School of Basic Medical Sciences/School of Biology and Engineering (School of Modern Industry for Health and Medicine), Guizhou Medical University, Guiyang 550025, China. AD - Immune Cells and Antibody Engineering Research Center in University of Guizhou Province, Key Laboratory of Biology and Medical Engineering, Guizhou Medical University, Guiyang 550025, China. FAU - Hu, Zuquan AU - Hu Z AUID- ORCID: 0000-0003-4978-4363 AD - Key Laboratory of Infectious Immune and Antibody Engineering in University of Guizhou Province, Engineering Research Center of Cellular Immunotherapy of Guizhou Province, School of Basic Medical Sciences/School of Biology and Engineering (School of Modern Industry for Health and Medicine), Guizhou Medical University, Guiyang 550025, China. AD - Immune Cells and Antibody Engineering Research Center in University of Guizhou Province, Key Laboratory of Biology and Medical Engineering, Guizhou Medical University, Guiyang 550025, China. FAU - Zeng, Zhu AU - Zeng Z AUID- ORCID: 0000-0003-0842-9402 AD - Key Laboratory of Infectious Immune and Antibody Engineering in University of Guizhou Province, Engineering Research Center of Cellular Immunotherapy of Guizhou Province, School of Basic Medical Sciences/School of Biology and Engineering (School of Modern Industry for Health and Medicine), Guizhou Medical University, Guiyang 550025, China. AD - Immune Cells and Antibody Engineering Research Center in University of Guizhou Province, Key Laboratory of Biology and Medical Engineering, Guizhou Medical University, Guiyang 550025, China. AD - State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550025, China. AD - Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education & Key Laboratory of Medical Molecular Biology of Guizhou Province, Guizhou Medical University, Guiyang 550004, China. LA - eng GR - 12132006, 32160224/the National Natural Science Foundation of China/ GR - 2022-381, 2021-5637, ZK2021-029, ZK2022-397, 2018-1412, 2016-5676, 2015-4021/the Guizhou Provincial Science and Technology Project/ GR - 2022-221/the Youth Science and Technology Talents Growth Project of Guizhou Ordinary Colleges and Universities/ GR - gzwkj2021-514/the Science and Technology Fund of Guizhou Provincial Health Commission/ GR - 2021-101/the Excellent Young Talents Plan of Guizhou Medical University/ PT - Journal Article PT - Review DEP - 20230201 PL - Switzerland TA - Gels JT - Gels (Basel, Switzerland) JID - 101696925 PMC - PMC9957133 OTO - NOTNLM OT - dendritic cells OT - hydrogels OT - immune function OT - mechanical cues COIS- The authors declare no conflict of interest. EDAT- 2023/02/25 06:00 MHDA- 2023/02/25 06:01 PMCR- 2023/02/01 CRDT- 2023/02/24 09:44 PHST- 2022/12/15 00:00 [received] PHST- 2023/01/16 00:00 [revised] PHST- 2023/01/25 00:00 [accepted] PHST- 2023/02/24 09:44 [entrez] PHST- 2023/02/25 06:00 [pubmed] PHST- 2023/02/25 06:01 [medline] PHST- 2023/02/01 00:00 [pmc-release] AID - gels9020116 [pii] AID - gels-09-00116 [pii] AID - 10.3390/gels9020116 [doi] PST - epublish SO - Gels. 2023 Feb 1;9(2):116. doi: 10.3390/gels9020116.