PMID- 36826491
OWN - NLM
STAT- MEDLINE
DCOM- 20230605
LR  - 20230606
IS  - 1432-086X (Electronic)
IS  - 0174-1551 (Linking)
VI  - 46
IP  - 6
DP  - 2023 Jun
TI  - A Retrospective Comparison of the Efficacy of Embolization with 
      Imipenem/Cilastatin and Microspheres in the Management of Chronic Shoulder Pain.
PG  - 748-757
LID - 10.1007/s00270-023-03385-2 [doi]
AB  - PURPOSE: To compare the efficacy of embolization with imipenem/cilastatin and 
      microspheres in chronic shoulder pain. METHODS: This retrospective study included 
      29 patients who underwent embolization for chronic shoulder pain between June 
      2017 and March 2022 with calibrated MSs from 100 to 250 microm or IMP/CS. The main 
      objective was the clinical success evaluated by the Minimum Clinically Important 
      Difference (MCID) at 3 months after the procedure, validated if the patient 
      responded yes to 2 questions: (1) Is the pain less severe than before the 
      procedure? (2) Are you satisfied with the procedure? The decrease in visual 
      analogue pain scale scores and the safety of the procedure were evaluated. 
      RESULTS: Embolization was achieved in all patients. In the MS group, 4/15 
      patients (26.7%) experienced clinical success at 3 months according to MCID 
      versus 10/14 patients (71.4%) in the IMP/CS group (p = 0.02). The mean VAS 
      decreases were respectively  - 28.6% +/- 34.6 in the MS group and  - 36.8% +/- 27.8 
      in the IMP/CS group at 1 month (p = 0.50), - 29.9% +/- 29.0 and - 39.6% +/- 23.0 at 
      3 months (p = 0.33) and - 30.6% +/- 32.8 and - 46.6% +/- 28.4 at 6 months after the 
      procedure (p = 0.26). Eleven patients (73.3%) in the MS group and 3 patients 
      (21.4%) in the IMP/CS group had complications (p = 0.01). Among them, 2/15 
      patients (13.3%) had transient skin ischaemia in the MS group. CONCLUSION: 
      Embolization with IMP/CS may be more effective and safer than MSs in the 
      management of chronic shoulder pain.
CI  - (c) 2023. Springer Science+Business Media, LLC, part of Springer Nature and the 
      Cardiovascular and Interventional Radiological Society of Europe (CIRSE).
FAU - Finas, Mathieu
AU  - Finas M
AD  - University of Grenoble-Alpes, Grenoble, France.
AD  - Department of Radiology, Grenoble-Alpes University Hospital, Grenoble, France.
FAU - Frandon, Julien
AU  - Frandon J
AD  - Department of Radiology, Nimes University Hospital, Nimes, France.
FAU - Gremen, Emeric
AU  - Gremen E
AD  - University of Grenoble-Alpes, Grenoble, France.
AD  - Department of Radiology, Grenoble-Alpes University Hospital, Grenoble, France.
FAU - Horteur, Clement
AU  - Horteur C
AD  - University of Grenoble-Alpes, Grenoble, France.
AD  - Department of Orthopaedic Surgery, Grenoble Alpes University Hospital, Grenoble, 
      France.
FAU - Benassayag, Michael
AU  - Benassayag M
AD  - Department of Orthopaedic Surgery, Medipole de Savoie Hospital, Challes-les-Eaux, 
      France.
FAU - Lateur, Gabriel
AU  - Lateur G
AD  - Department of Orthopaedic Surgery Department, Albertville Hospital, Albertville, 
      France.
FAU - Pailhe, Regis
AU  - Pailhe R
AD  - University of Grenoble-Alpes, Grenoble, France.
AD  - Department of Orthopaedic Surgery, Grenoble Alpes University Hospital, Grenoble, 
      France.
FAU - Ferretti, Gilbert
AU  - Ferretti G
AD  - University of Grenoble-Alpes, Grenoble, France.
AD  - Department of Radiology, Grenoble-Alpes University Hospital, Grenoble, France.
FAU - Bellier, Alexandre
AU  - Bellier A
AD  - University of Grenoble-Alpes, Grenoble, France.
AD  - Clinical Research Department, Grenoble-Alpes University Hospital, Grenoble, 
      France.
FAU - Ghelfi, Julien
AU  - Ghelfi J
AUID- ORCID: 0000-0002-9039-6488
AD  - University of Grenoble-Alpes, Grenoble, France. jghelfi@chu-grenoble.fr.
AD  - Department of Radiology, Grenoble-Alpes University Hospital, Grenoble, France. 
      jghelfi@chu-grenoble.fr.
AD  - Institute for Advanced Biosciences, INSERM U1209, CNRS UMR 5309, University of 
      Grenoble-Alpes, Grenoble, France. jghelfi@chu-grenoble.fr.
LA  - eng
PT  - Journal Article
DEP - 20230224
PL  - United States
TA  - Cardiovasc Intervent Radiol
JT  - Cardiovascular and interventional radiology
JID - 8003538
RN  - 71OTZ9ZE0A (Imipenem)
RN  - 141A6AMN38 (Cilastatin)
RN  - 0 (Drug Combinations)
RN  - 92309-29-0 (Cilastatin, Imipenem Drug Combination)
SB  - IM
CIN - Cardiovasc Intervent Radiol. 2023 Jun;46(6):758-759. PMID: 37106125
MH  - Humans
MH  - Retrospective Studies
MH  - *Imipenem/therapeutic use
MH  - *Cilastatin/therapeutic use
MH  - Microspheres
MH  - Shoulder Pain/therapy
MH  - Drug Combinations
MH  - Cilastatin, Imipenem Drug Combination
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Chronic shoulder pain
OT  - Cilastatin
OT  - Embolization
OT  - Imipenem
OT  - Neovessels
OT  - Safety
EDAT- 2023/02/25 06:00
MHDA- 2023/06/05 06:43
CRDT- 2023/02/24 11:14
PHST- 2022/09/21 00:00 [received]
PHST- 2023/01/31 00:00 [accepted]
PHST- 2023/06/05 06:43 [medline]
PHST- 2023/02/25 06:00 [pubmed]
PHST- 2023/02/24 11:14 [entrez]
AID - 10.1007/s00270-023-03385-2 [pii]
AID - 10.1007/s00270-023-03385-2 [doi]
PST - ppublish
SO  - Cardiovasc Intervent Radiol. 2023 Jun;46(6):748-757. doi: 
      10.1007/s00270-023-03385-2. Epub 2023 Feb 24.