PMID- 36827337
OWN - NLM
STAT- MEDLINE
DCOM- 20230228
LR  - 20230410
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 18
IP  - 2
DP  - 2023
TI  - Sex differences in the association between systemic oxidative stress status and 
      optic nerve head blood flow in normal-tension glaucoma.
PG  - e0282047
LID - 10.1371/journal.pone.0282047 [doi]
LID - e0282047
AB  - PURPOSE: To investigate the association of systemic oxidative stress markers and 
      optic nerve head (ONH) blood flow in normal-tension glaucoma (NTG) patients, as 
      well as sex differences in this association. METHODS: This was a cross-sectional 
      study of 235 eyes with NTG of 134 patients (56 male, 78 female; mean age, 
      60.9+/-14.1 years). Laser speckle flowgraphy (LSFG) was used to measure ONH blood 
      flow (mean blur rate in the tissue area of the ONH; MBR-T) and LSFG 
      pulse-waveform parameters, including flow acceleration index in the tissue area 
      of the ONH (FAI-T). Oxidative stress markers, diacron-reactive oxygen metabolites 
      (d-ROMs), and biological antioxidant potential (BAP) were measured with a free 
      radical elective evaluator. Spearman's rank correlation test and a multivariate 
      linear mixed-effect model were used to investigate factors associated with ONH 
      blood flow. RESULTS: MBR-T was significantly correlated with age (rs = -0.28, p < 
      0.001), mean arterial pressure (rs = -0.20, p = 0.002), intraocular pressure (rs 
      = 0.24, p < 0.001), peripapillary retinal nerve fiber layer thickness (rs = 0.62, 
      p < 0.001), and disc area (rs = -0.26, p < 0.001), but not with serum d-ROM 
      level. Separate analyses of the subjects divided by sex showed that BAP was 
      positively correlated to MBR-T (rs = 0.21, p = 0.036) and FAI-T (rs = 0.36, p < 
      0.001) only in male subjects. Similarly, BAP was significantly associated with 
      MBR-T (beta = 0.25, p = 0.026) and FAI-T (beta = 0.37, p < 0.001) in male subjects in a 
      multivariate linear mixed-effect model. CONCLUSION: A lower serum antioxidant 
      level, as indicated by BAP, was associated with reduced ONH blood flow only in 
      male NTG patients. Our findings suggest that there are sex differences in the 
      involvement of oxidative stress in the pathogenesis of reduced ocular blood flow 
      in NTG.
CI  - Copyright: (c) 2023 Sato et al. This is an open access article distributed under 
      the terms of the Creative Commons Attribution License, which permits unrestricted 
      use, distribution, and reproduction in any medium, provided the original author 
      and source are credited.
FAU - Sato, Masataka
AU  - Sato M
AD  - Department of Ophthalmology, Tohoku University Graduate School of Medicine, 
      Miyagi, Japan.
FAU - Yasuda, Masayuki
AU  - Yasuda M
AD  - Department of Ophthalmology, Tohoku University Graduate School of Medicine, 
      Miyagi, Japan.
FAU - Takahashi, Nana
AU  - Takahashi N
AD  - Department of Ophthalmology, Tohoku University Graduate School of Medicine, 
      Miyagi, Japan.
FAU - Hashimoto, Kazuki
AU  - Hashimoto K
AD  - Department of Ophthalmology, Tohoku University Graduate School of Medicine, 
      Miyagi, Japan.
FAU - Himori, Noriko
AU  - Himori N
AD  - Department of Ophthalmology, Tohoku University Graduate School of Medicine, 
      Miyagi, Japan.
AD  - Department of Aging Vision Healthcare, Tohoku University Graduate School of 
      Biomedical Engineering, Miyagi, Japan.
FAU - Nakazawa, Toru
AU  - Nakazawa T
AUID- ORCID: 0000-0002-5591-4155
AD  - Department of Ophthalmology, Tohoku University Graduate School of Medicine, 
      Miyagi, Japan.
AD  - Department of Ophthalmic Imaging and Information Analytics, Tohoku University 
      Graduate School of Medicine, Miyagi, Japan.
AD  - Department of Retinal Disease Control, Tohoku University Graduate School of 
      Medicine, Miyagi, Japan.
AD  - Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of 
      Medicine, Miyagi, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230224
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Antioxidants)
SB  - IM
MH  - Humans
MH  - Female
MH  - Male
MH  - Middle Aged
MH  - Aged
MH  - *Optic Disk/blood supply
MH  - Antioxidants
MH  - Cross-Sectional Studies
MH  - Sex Characteristics
MH  - Regional Blood Flow/physiology
MH  - *Low Tension Glaucoma
MH  - Intraocular Pressure
MH  - Oxidative Stress
MH  - Laser-Doppler Flowmetry
MH  - Blood Flow Velocity/physiology
PMC - PMC9955941
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/02/25 06:00
MHDA- 2023/03/03 06:00
PMCR- 2023/02/24
CRDT- 2023/02/24 13:57
PHST- 2022/08/17 00:00 [received]
PHST- 2023/02/06 00:00 [accepted]
PHST- 2023/02/24 13:57 [entrez]
PHST- 2023/02/25 06:00 [pubmed]
PHST- 2023/03/03 06:00 [medline]
PHST- 2023/02/24 00:00 [pmc-release]
AID - PONE-D-22-21223 [pii]
AID - 10.1371/journal.pone.0282047 [doi]
PST - epublish
SO  - PLoS One. 2023 Feb 24;18(2):e0282047. doi: 10.1371/journal.pone.0282047. 
      eCollection 2023.