PMID- 36827542
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230301
IS  - 2311-553X (Electronic)
IS  - 2311-553X (Linking)
VI  - 9
IP  - 1
DP  - 2023 Jan 19
TI  - Diagnostic and Prognostic Value of microRNAs in Patients with Laryngeal Cancer: A 
      Systematic Review.
LID - 10.3390/ncrna9010009 [doi]
LID - 9
AB  - Laryngeal squamous cell cancer (LSCC) is one of the most common malignant tumors 
      of the head and neck region, with a poor survival rate (5-year overall survival 
      50-80%) as a consequence of an advanced-stage diagnosis and high recurrence rate. 
      Tobacco smoking and alcohol abuse are the main risk factors of LSCC development. 
      An early diagnosis of LSCC, a prompt detection of recurrence and a more precise 
      monitoring of the efficacy of different treatment modalities are currently needed 
      to reduce the mortality. Therefore, the identification of effective diagnostic 
      and prognostic biomarkers for LSCC is crucial to guide disease management and 
      improve clinical outcomes. In the past years, a dysregulated expression of small 
      non-coding RNAs, including microRNAs (miRNAs), has been reported in many human 
      cancers, including LSCC, and many miRNAs have been explored for their diagnostic 
      and prognostic potential and proposed as biomarkers. We searched electronic 
      databases for original papers that were focused on miRNAs and LSCC, using the 
      Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 
      protocol. According to the outcome, 566 articles were initially screened, of 
      which 177 studies were selected and included in the analysis. In this systematic 
      review, we provide an overview of the current literature on the function and the 
      potential diagnostic and prognostic role of tissue and circulating miRNAs in 
      LSCC.
FAU - Broseghini, Elisabetta
AU  - Broseghini E
AD  - Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, 
      Universita di Bologna, 40138 Bologna, Italy.
FAU - Filippini, Daria Maria
AU  - Filippini DM
AD  - Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, 
      Universita di Bologna, 40138 Bologna, Italy.
AD  - Division of Medical Oncology, IRCCS Azienda Ospedaliero, Universitaria 
      Policlinico Sant'Orsola Malpighi of Bologna, 40138 Bologna, Italy.
FAU - Fabbri, Laura
AU  - Fabbri L
AD  - Division of Medical Oncology, IRCCS Azienda Ospedaliero, Universitaria 
      Policlinico Sant'Orsola Malpighi of Bologna, 40138 Bologna, Italy.
FAU - Leonardi, Roberta
AU  - Leonardi R
AD  - Division of Medical Oncology, IRCCS Azienda Ospedaliero, Universitaria 
      Policlinico Sant'Orsola Malpighi of Bologna, 40138 Bologna, Italy.
FAU - Abeshi, Andi
AU  - Abeshi A
AUID- ORCID: 0000-0001-7110-9503
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, IRCCS Azienda 
      Ospedaliero, Universitaria di Bologna, Policlinico S. Orsola-Malpighi, 40138 
      Bologna, Italy.
FAU - Dal Molin, Davide
AU  - Dal Molin D
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, IRCCS Azienda 
      Ospedaliero, Universitaria di Bologna, Policlinico S. Orsola-Malpighi, 40138 
      Bologna, Italy.
FAU - Fermi, Matteo
AU  - Fermi M
AUID- ORCID: 0000-0002-2727-0321
AD  - Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, 
      Universita di Bologna, 40138 Bologna, Italy.
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, IRCCS Azienda 
      Ospedaliero, Universitaria di Bologna, Policlinico S. Orsola-Malpighi, 40138 
      Bologna, Italy.
FAU - Ferracin, Manuela
AU  - Ferracin M
AUID- ORCID: 0000-0002-1595-6887
AD  - Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, 
      Universita di Bologna, 40138 Bologna, Italy.
AD  - IRCCS Azienda Ospedaliero, Universitaria di Bologna, 40138 Bologna, Italy.
FAU - Fernandez, Ignacio Javier
AU  - Fernandez IJ
AD  - Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, 
      Universita di Bologna, 40138 Bologna, Italy.
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, IRCCS Azienda 
      Ospedaliero, Universitaria di Bologna, Policlinico S. Orsola-Malpighi, 40138 
      Bologna, Italy.
LA  - eng
GR  - IG 2021 - ID. 25789/Italian Association for Cancer Research/
PT  - Journal Article
PT  - Review
DEP - 20230119
PL  - Switzerland
TA  - Noncoding RNA
JT  - Non-coding RNA
JID - 101652294
PMC - PMC9966707
OTO - NOTNLM
OT  - LSCC (laryngeal squamous cell carcinoma)
OT  - biomarkers
OT  - microRNA
COIS- The authors declare no conflict of interest.
EDAT- 2023/02/25 06:00
MHDA- 2023/02/25 06:01
PMCR- 2023/01/19
CRDT- 2023/02/24 15:13
PHST- 2022/12/23 00:00 [received]
PHST- 2023/01/16 00:00 [revised]
PHST- 2023/01/17 00:00 [accepted]
PHST- 2023/02/24 15:13 [entrez]
PHST- 2023/02/25 06:00 [pubmed]
PHST- 2023/02/25 06:01 [medline]
PHST- 2023/01/19 00:00 [pmc-release]
AID - ncrna9010009 [pii]
AID - ncrna-09-00009 [pii]
AID - 10.3390/ncrna9010009 [doi]
PST - epublish
SO  - Noncoding RNA. 2023 Jan 19;9(1):9. doi: 10.3390/ncrna9010009.