PMID- 36828662 OWN - NLM STAT- MEDLINE DCOM- 20230228 LR - 20231120 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 13 IP - 2 DP - 2023 Feb 24 TI - Association between adiponectin and newly diagnosed type 2 diabetes in population with the clustering of obesity, dyslipidaemia and hypertension: a cross-sectional study. PG - e060377 LID - 10.1136/bmjopen-2021-060377 [doi] LID - e060377 AB - OBJECTIVES: Adiponectin is closely related to glucose metabolism and traditional diabetes risk factors (obesity, hypertension and dyslipidaemia). We aimed to explore the association between adiponectin levels and newly diagnosed type 2 diabetes mellitus (T2DM) and pre-diabetes in subgroups classified according to T2DM risk factors. SETTING: Sun Yat-sen Memorial Hospital of Sun Yat-sen University. PARTICIPANTS: 3680 individuals (1753 men and 1927 women) aged 18-70 years from Guangzhou and Dongguan, China, were enrolled from December 2018 to October 2019. PRIMARY AND SECONDARY OUTCOME MEASURES: T2DM was defined as fasting plasma glucose (FPG)>/=7.0 mmol/L or HbA1c>/=6.5%, and pre-diabetes was defined as 6.1 mmol/L/=1 T2DM risk factor, whereas its association was not consistently significant in the population with all three T2DM risk factors. For instance, participants were more likely to have diabetes or prediabetes with low levels of adiponectin when they had >/= one T2DM risk factor (quartile 2 vs. 1: OR 0.71 [95%CI: 0.56-0.89]; P=0.003; quartile 3 vs. 1: OR 0.57 [95%CIs: 0.44-0.72]; P<0.001; and quartile 4 vs. 1: OR 0.52 [95%CIs: 0.40-0.67]; P<0.001). CONCLUSION: Adiponectin was negatively associated with diabetes and pre-diabetes in a population with few T2DM risk factors, while their relationship gradually attenuated with the accumulation of T2DM risk factors, especially in a population with coexisting diseases such as obesity, hypertension and dyslipidaemia. CI - (c) Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Hong, Xiaosi AU - Hong X AD - Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Guangzhou, China. AD - Guang Dong Clinical Research Center for Metabolic Diseases, Sun Yat-sen Memorial Hospital, Guangzhou, China. FAU - Zhang, Xiaoyun AU - Zhang X AD - Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Guangzhou, China. AD - Guang Dong Clinical Research Center for Metabolic Diseases, Sun Yat-sen Memorial Hospital, Guangzhou, China. FAU - You, Lili AU - You L AUID- ORCID: 0000-0001-6815-5939 AD - Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Guangzhou, China. AD - Guang Dong Clinical Research Center for Metabolic Diseases, Sun Yat-sen Memorial Hospital, Guangzhou, China. FAU - Li, Feng AU - Li F AD - Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Guangzhou, China. AD - Guang Dong Clinical Research Center for Metabolic Diseases, Sun Yat-sen Memorial Hospital, Guangzhou, China. FAU - Lian, Hong AU - Lian H AD - Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Guangzhou, China. AD - Guang Dong Clinical Research Center for Metabolic Diseases, Sun Yat-sen Memorial Hospital, Guangzhou, China. FAU - Wang, Jiahuan AU - Wang J AUID- ORCID: 0000-0001-9575-0178 AD - Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Guangzhou, China. AD - Guang Dong Clinical Research Center for Metabolic Diseases, Sun Yat-sen Memorial Hospital, Guangzhou, China. FAU - Mao, Na AU - Mao N AD - Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Guangzhou, China. AD - Guang Dong Clinical Research Center for Metabolic Diseases, Sun Yat-sen Memorial Hospital, Guangzhou, China. FAU - Ren, Meng AU - Ren M AUID- ORCID: 0000-0001-9935-1449 AD - Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Guangzhou, China. AD - Guang Dong Clinical Research Center for Metabolic Diseases, Sun Yat-sen Memorial Hospital, Guangzhou, China. FAU - Li, Yan AU - Li Y AD - Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Guangzhou, China. AD - Guang Dong Clinical Research Center for Metabolic Diseases, Sun Yat-sen Memorial Hospital, Guangzhou, China. FAU - Wang, Chuan AU - Wang C AD - Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Guangzhou, China skendo@163.com 195544590@qq.com. AD - Guang Dong Clinical Research Center for Metabolic Diseases, Sun Yat-sen Memorial Hospital, Guangzhou, China. FAU - Sun, Kan AU - Sun K AUID- ORCID: 0000-0002-3471-7689 AD - Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Guangzhou, China skendo@163.com 195544590@qq.com. AD - Guang Dong Clinical Research Center for Metabolic Diseases, Sun Yat-sen Memorial Hospital, Guangzhou, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20230224 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 RN - 0 (Adiponectin) RN - 0 (Glycated Hemoglobin) RN - 0 (Blood Glucose) SB - IM MH - Male MH - Humans MH - Female MH - *Diabetes Mellitus, Type 2/epidemiology MH - *Prediabetic State MH - Cross-Sectional Studies MH - Adiponectin MH - Glycated Hemoglobin MH - *Hypertension/epidemiology MH - Obesity/complications MH - *Dyslipidemias/epidemiology MH - Cluster Analysis MH - Blood Glucose/metabolism PMC - PMC9972409 OTO - NOTNLM OT - DIABETES & ENDOCRINOLOGY OT - Diabetes & endocrinology OT - General diabetes OT - Lipid disorders COIS- Competing interests: None declared. EDAT- 2023/02/25 06:00 MHDA- 2023/03/03 06:00 PMCR- 2023/02/24 CRDT- 2023/02/24 21:49 PHST- 2023/02/24 21:49 [entrez] PHST- 2023/02/25 06:00 [pubmed] PHST- 2023/03/03 06:00 [medline] PHST- 2023/02/24 00:00 [pmc-release] AID - bmjopen-2021-060377 [pii] AID - 10.1136/bmjopen-2021-060377 [doi] PST - epublish SO - BMJ Open. 2023 Feb 24;13(2):e060377. doi: 10.1136/bmjopen-2021-060377.