PMID- 36828785
OWN - NLM
STAT- MEDLINE
DCOM- 20230508
LR  - 20230508
IS  - 2198-3844 (Electronic)
IS  - 2198-3844 (Linking)
VI  - 10
IP  - 13
DP  - 2023 May
TI  - Metal-Organic Framework Functionalized Bioceramic Scaffolds with Antioxidative 
      Activity for Enhanced Osteochondral Regeneration.
PG  - e2206875
LID - 10.1002/advs.202206875 [doi]
LID - 2206875
AB  - Osteoarthritis (OA) is a degenerative disease that often causes cartilage lesions 
      and even osteochondral damage. Osteochondral defects induced by OA are 
      accompanied by an inflammatory arthrosis microenvironment with overproduced 
      reactive oxygen species (ROS), resulting in the exacerbation of defects and 
      difficulty regenerating osteochondral tissues. Therefore, it is urgently needed 
      to develop osteochondral scaffolds that can not only promote the integrated 
      regeneration of cartilage and subchondral bone, but also possess ROS-scavenging 
      ability to protect tissues from oxidative stress. Herein, zinc-cobalt bimetallic 
      organic framework (Zn/Co-MOF) functionalized bioceramic scaffolds are designed 
      for repairing osteochondral defects under OA environment. By functionalizing 
      Zn/Co-MOF on the 3D-printed beta-tricalcium phosphate (beta-TCP) scaffolds, the 
      Zn/Co-MOF functionalized beta-TCP (MOF-TCP) scaffolds with broad-spectrum 
      ROS-scavenging ability are successfully developed. Benefiting from its catalytic 
      active sites and degradation products, Zn/Co-MOF endows the scaffolds with 
      excellent antioxidative and anti-inflammatory properties to protect cells from 
      ROS invasion, as well as dual-bioactivities of simultaneously inducing osteogenic 
      and chondrogenic differentiation in vitro. Furthermore, in vivo results confirm 
      that MOF-TCP scaffolds accelerate the integrated regeneration of cartilage and 
      subchondral bone in severe osteochondral defects. This study offers a promising 
      strategy for treating defects induced by OA as well as other inflammatory 
      diseases.
CI  - (c) 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.
FAU - Shu, Chaoqin
AU  - Shu C
AD  - State Key Laboratory of High Performance Ceramics and Superfine Microstructure, 
      Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. 
      R. China.
FAU - Qin, Chen
AU  - Qin C
AD  - State Key Laboratory of High Performance Ceramics and Superfine Microstructure, 
      Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. 
      R. China.
FAU - Chen, Lei
AU  - Chen L
AD  - State Key Laboratory of High Performance Ceramics and Superfine Microstructure, 
      Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. 
      R. China.
FAU - Wang, Yufeng
AU  - Wang Y
AD  - State Key Laboratory of High Performance Ceramics and Superfine Microstructure, 
      Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. 
      R. China.
FAU - Shi, Zhe
AU  - Shi Z
AD  - State Key Laboratory of High Performance Ceramics and Superfine Microstructure, 
      Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. 
      R. China.
FAU - Yu, Jiangming
AU  - Yu J
AD  - Department of Orthopaedics, Tongren Hospital, Shanghai Jiaotong University, 
      Shanghai, 200336, P. R. China.
FAU - Huang, Jimin
AU  - Huang J
AD  - State Key Laboratory of High Performance Ceramics and Superfine Microstructure, 
      Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. 
      R. China.
AD  - Center of Materials Science and Optoelectronics Engineering, University of 
      Chinese Academy of Sciences, Beijing, 100049, P. R. China.
FAU - Zhao, Chaoqian
AU  - Zhao C
AD  - State Key Laboratory of High Performance Ceramics and Superfine Microstructure, 
      Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. 
      R. China.
FAU - Huan, Zhiguang
AU  - Huan Z
AD  - State Key Laboratory of High Performance Ceramics and Superfine Microstructure, 
      Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. 
      R. China.
AD  - Center of Materials Science and Optoelectronics Engineering, University of 
      Chinese Academy of Sciences, Beijing, 100049, P. R. China.
FAU - Wu, Chengtie
AU  - Wu C
AD  - State Key Laboratory of High Performance Ceramics and Superfine Microstructure, 
      Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. 
      R. China.
AD  - Center of Materials Science and Optoelectronics Engineering, University of 
      Chinese Academy of Sciences, Beijing, 100049, P. R. China.
FAU - Zhu, Min
AU  - Zhu M
AD  - School of Materials and Chemistry, University of Shanghai for Science and 
      Technology, Shanghai, 200093, P. R. China.
FAU - Zhu, Yufang
AU  - Zhu Y
AUID- ORCID: 0000-0001-9031-8861
AD  - State Key Laboratory of High Performance Ceramics and Superfine Microstructure, 
      Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. 
      R. China.
AD  - Center of Materials Science and Optoelectronics Engineering, University of 
      Chinese Academy of Sciences, Beijing, 100049, P. R. China.
LA  - eng
GR  - 32271393/National Natural Science Foundation of China/
GR  - 52072246/National Natural Science Foundation of China/
GR  - 51872185/National Natural Science Foundation of China/
GR  - 21S31900900/Science and Technology Commission of Shanghai Municipality/
GR  - 21520712300/Science and Technology Commission of Shanghai Municipality/
GR  - 20ZR1469800/Natural Science Foundation of Shanghai/
GR  - YG2022ZD030/Medical and Industrial Cross Research Foundation of "Star of Jiaotong 
      University" Program of Shanghai Jiao Tong University/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230224
PL  - Germany
TA  - Adv Sci (Weinh)
JT  - Advanced science (Weinheim, Baden-Wurttemberg, Germany)
JID - 101664569
RN  - 0 (beta-tricalcium phosphate)
RN  - 0 (Metal-Organic Frameworks)
RN  - 0 (Antioxidants)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - *Tissue Scaffolds/chemistry
MH  - *Metal-Organic Frameworks/pharmacology
MH  - Antioxidants/pharmacology
MH  - Reactive Oxygen Species
PMC - PMC10161093
OTO - NOTNLM
OT  - antioxidative stress
OT  - bioceramic scaffolds
OT  - metal-organic frameworks
OT  - osteochondral regeneration
COIS- The authors declare no conflict of interest.
EDAT- 2023/02/25 06:00
MHDA- 2023/05/08 06:42
PMCR- 2023/02/24
CRDT- 2023/02/24 22:33
PHST- 2023/01/19 00:00 [revised]
PHST- 2022/11/22 00:00 [received]
PHST- 2023/05/08 06:42 [medline]
PHST- 2023/02/25 06:00 [pubmed]
PHST- 2023/02/24 22:33 [entrez]
PHST- 2023/02/24 00:00 [pmc-release]
AID - ADVS5307 [pii]
AID - 10.1002/advs.202206875 [doi]
PST - ppublish
SO  - Adv Sci (Weinh). 2023 May;10(13):e2206875. doi: 10.1002/advs.202206875. Epub 2023 
      Feb 24.