PMID- 36829093
OWN - NLM
STAT- MEDLINE
DCOM- 20230424
LR  - 20230424
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 30
IP  - 18
DP  - 2023 Apr
TI  - Coexposure to multiple metals and renal tubular damage: a population-based 
      cross-sectional study in China's rural regions.
PG  - 52421-52432
LID - 10.1007/s11356-023-25909-6 [doi]
AB  - Previous studies have indicated that exposure to a single toxic metal can cause 
      renal tubular damage, while evidence about the effects of multimetal exposure on 
      renal tubular damage is relatively limited. We aimed to evaluate the 
      relationships of multimetal coexposure with renal tubular damage in adults in 
      heavy metal-polluted rural regions of China. A cross-sectional study of 1918 
      adults in China's heavy metal-contaminated rural regions was conducted. 
      Inductively coupled plasma-mass spectrometry (ICP-MS) was used to measure the 
      plasma levels of 18 metals in participants, and immune turbidimetry was used to 
      measure sensitive biological indicators, reflecting renal tubular damage 
      (including retinol-binding protein and beta2-microglobulin). Least absolute 
      shrinkage and selection operator (LASSO) penalized regression analysis, logistic 
      and linear regression analysis, restricted cubic spline (RCS) regression analysis 
      and the Bayesian kernel machine regression (BKMR) method were used to explore 
      associations of multimetal coexposure with renal tubular damage risk or renal 
      tubular damage indicators. Plasma selenium, cadmium, arsenic, and iron were 
      identified as the main plasma metals associated with renal tubular damage risk 
      after dimensionality reduction. Multimetal regression models showed that selenium 
      was positively associated, and iron was negatively associated with renal tubular 
      damage risk or its biological indicators. Multimetal RCS analyses additionally 
      revealed a non-linear relationship of selenium with renal tubular damage risk. 
      The BKMR models showed that the metal mixtures were positively associated with 
      biological indicators of renal tubular damage when the metal mixtures were above 
      the 50th percentile of concentration. Our findings indicated that natural 
      exposure to high levels of multimetal mixtures increases the risk of renal 
      tubular damage. Under the conditions of multimetal exposure, selenium was 
      positively associated, and iron was negatively associated with renal tubular 
      damage risk or its biological indicators.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Quan, JingJing
AU  - Quan J
AD  - Department of Nephrology, The Third Xiangya Hospital, Central South University, 
      Changsha, 410013, China.
FAU - Li, Yan
AU  - Li Y
AD  - Center for Clinical Pharmacology, The Third Xiangya Hospital, Central South 
      University, Changsha, 410013, China.
FAU - Shen, Minxue
AU  - Shen M
AD  - Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 
      410008, China.
AD  - Department of Social Medicine and Health Management, Xiangya School of Public 
      Health, Central South University, Changsha, 410078, China.
FAU - Lu, Yao
AU  - Lu Y
AD  - Center for Clinical Pharmacology, The Third Xiangya Hospital, Central South 
      University, Changsha, 410013, China.
AD  - Department of Life Science and Medicine, King's College London, London, UK.
FAU - Yuan, Hong
AU  - Yuan H
AD  - Center for Clinical Pharmacology, The Third Xiangya Hospital, Central South 
      University, Changsha, 410013, China.
FAU - Yi, Bin
AU  - Yi B
AD  - Department of Nephrology, The Third Xiangya Hospital, Central South University, 
      Changsha, 410013, China.
FAU - Chen, Xiang
AU  - Chen X
AD  - Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 
      410008, China.
FAU - Huang, Zhijun
AU  - Huang Z
AUID- ORCID: 0000-0003-1539-5212
AD  - Department of Nephrology, The Third Xiangya Hospital, Central South University, 
      Changsha, 410013, China. huangzj@csu.edu.cn.
AD  - Center for Clinical Pharmacology, The Third Xiangya Hospital, Central South 
      University, Changsha, 410013, China. huangzj@csu.edu.cn.
LA  - eng
GR  - 82173905/the National Natural Science Foundation of China/
GR  - 82070759/the National Natural Science Foundation of China/
GR  - 2015FY111100/the Ministry of Science and Technology of China/
PT  - Journal Article
DEP - 20230225
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - H6241UJ22B (Selenium)
RN  - 0 (Metals, Heavy)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Adult
MH  - Humans
MH  - Cross-Sectional Studies
MH  - *Selenium/analysis
MH  - Bayes Theorem
MH  - Environmental Exposure/analysis
MH  - *Metals, Heavy/analysis
MH  - Iron/analysis
OTO - NOTNLM
OT  - BKMR
OT  - Cross-sectional study
OT  - LASSO regression
OT  - Metal coexposure
OT  - Renal tubular damage
OT  - Retinol binding protein
OT  - beta2-microglobulin
EDAT- 2023/02/25 06:00
MHDA- 2023/04/24 06:42
CRDT- 2023/02/24 23:36
PHST- 2022/09/22 00:00 [received]
PHST- 2023/02/09 00:00 [accepted]
PHST- 2023/04/24 06:42 [medline]
PHST- 2023/02/25 06:00 [pubmed]
PHST- 2023/02/24 23:36 [entrez]
AID - 10.1007/s11356-023-25909-6 [pii]
AID - 10.1007/s11356-023-25909-6 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2023 Apr;30(18):52421-52432. doi: 
      10.1007/s11356-023-25909-6. Epub 2023 Feb 25.