PMID- 36829206
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230228
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 15
IP  - 1
DP  - 2023 Feb 24
TI  - Level of 25-hydroxyvitamin D and vitamin D receptor in diabetic foot ulcer and 
      factor associated with diabetic foot ulcers.
PG  - 30
LID - 10.1186/s13098-023-01002-3 [doi]
LID - 30
AB  - BACKGROUND: At present, there is no clinical study to elucidate the correlation 
      between vitamin D deficiency and the incidence of diabetic foot osteomyelitis 
      (DFO).This study aims to clarify levels of 25-hydroxyvitamin D [25(OH)VD] in 
      peripheral blood and vitamin D receptor (VDR) expression in wound margin tissues 
      (T-VDR) of patients with type 2 diabetes mellitus (T2DM) with diabetic foot ulcer 
      (DFU) and DFO, and to determine its correlation with treatment outcomes of DFU 
      and DFO, and and its value as a potential biomarker for the diagnosis of DFU and 
      DFO. METHODS: 156 T2DM patients with DFU (DFU group), 100 T2DM patients without 
      DFU (T2DM group), and 100 healthy controls (NC group). The DFU group patients 
      were subdivided into DFO (n = 80) and NDFO groups (n = 76). The level of serum 
      25(OH)VD was measured via chemiluminescence immunoassay, and T-VDR expression 
      level was determined by quantitative real-time PCR. RESULTS: The levels of serum 
      25(OH)VD in the DFU group were significantly lower than the T2DM group [(10.3 
      (5.8, 18.7) vs 15.7 (8.6, 24.6) ng/mL, P = 0.002)]. Similarly, the levels of 
      serum 25(OH)VD and T-VDR expression in the DFO group were statistically lower 
      than the NDFO group [9.2 (5.2, 20.5) vs 12.8 (6.9, 22.1) ng/mL, P = 0.006)], 
      [1.96 (0.61, 3.97) vs 3.11 (1.36, 5.11), P = 0.004)], respectively. Furthermore, 
      the levels of serum 25(OH)VD and T-VDR expression in DFU patients were positively 
      correlated with the ulcer healing rate of foot ulcer after 8 weeks of treatment ( 
      P = 0.031, P = 0.016, respectively). Multivariate logistic regression analysis 
      showed that low level of serum 25(OH)VD was an independent risk factor for DFU 
      and DFO (OR(DFU) = 2.42, OR(DFO) = 3.05, P = 0.008, 0.001, respectively), and 
      decreased T-VDR expression level was an independent risk factor for DFO 
      (OR = 2.83, P = 0.004). Meanwhile, the ROC curve analysis indicated that the AUC 
      of serum 25(OH)VD level for the diagnosis of DFU and DFO was 0.821 (95% CI, 
      0.754-0.886, P < 0.001) and 0.786 (95%CI, 0.643-0.867, P < 0.001), respectively. 
      When establishing a diagnosis of DFO, the AUC of T-VDR expression level was 0.703 
      (95%CI: 0.618-0.853, P < 0.001). CONCLUSIONS: The levels of serum 25(OH)VD and 
      T-VDR expression in DFU and DFO decreased. Serum 25(OH)VD and T-VDR are 
      potentially valuable biomarkers for diagnosis and prognosis of DFU and DFO. .
CI  - (c) 2023. The Author(s).
FAU - Tang, Ying
AU  - Tang Y
AD  - Department of Endocrinology, The First Affiliated Hospital of Anhui Medical 
      University, Hefei, Anhui, People's Republic of China.
FAU - Huang, Yixuan
AU  - Huang Y
AD  - Department of Endocrinology, The First Affiliated Hospital of Anhui Medical 
      University, Hefei, Anhui, People's Republic of China.
FAU - Luo, Li
AU  - Luo L
AD  - Department of Endocrinology, The First Affiliated Hospital of Anhui Medical 
      University, Hefei, Anhui, People's Republic of China.
FAU - Xu, Murong
AU  - Xu M
AD  - Department of Endocrinology, The First Affiliated Hospital of Anhui Medical 
      University, Hefei, Anhui, People's Republic of China.
FAU - Deng, Datong
AU  - Deng D
AD  - Department of Endocrinology, The First Affiliated Hospital of Anhui Medical 
      University, Hefei, Anhui, People's Republic of China.
FAU - Fang, Zhaohui
AU  - Fang Z
AD  - Department of Endocrinology, The First Affiliated Hospital of Anhui University of 
      Traditional Chinese Medicine, Hefei, Anhui, People's Republic of China.
FAU - Zhao, Xiaotong
AU  - Zhao X
AD  - Department of Endocrinology, The First Affiliated Hospital of Anhui Medical 
      University, Hefei, Anhui, People's Republic of China. zxt522154846@163.com.
FAU - Chen, Mingwei
AU  - Chen M
AD  - Department of Endocrinology, The First Affiliated Hospital of Anhui Medical 
      University, Hefei, Anhui, People's Republic of China. chmw1@163.com.
AD  - Department of Endocrinology, The First Affiliated Hospital of Anhui University of 
      Traditional Chinese Medicine, Hefei, Anhui, People's Republic of China. 
      chmw1@163.com.
LA  - eng
GR  - NO.2108085MH269/Natural Science Foundation of Anhui Province/
GR  - KJ2021A0274/Natural Science Research Project of Colleges and Universities/
GR  - GXXT-2020-025/Anhui University Cooperation and Public Health Collaborative 
      Innovation Project/
PT  - Journal Article
DEP - 20230224
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC9951493
OTO - NOTNLM
OT  - 25-Hydroxyvitamin D
OT  - Diabetic foot osteomyelitis
OT  - Diabetic foot ulcer
OT  - Type 2 diabetes mellitus
OT  - Vitamin D receptor
COIS- The authors declare that they have no competing interests.
EDAT- 2023/02/25 06:00
MHDA- 2023/02/25 06:01
PMCR- 2023/02/24
CRDT- 2023/02/24 23:45
PHST- 2022/11/28 00:00 [received]
PHST- 2023/02/17 00:00 [accepted]
PHST- 2023/02/24 23:45 [entrez]
PHST- 2023/02/25 06:00 [pubmed]
PHST- 2023/02/25 06:01 [medline]
PHST- 2023/02/24 00:00 [pmc-release]
AID - 10.1186/s13098-023-01002-3 [pii]
AID - 1002 [pii]
AID - 10.1186/s13098-023-01002-3 [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2023 Feb 24;15(1):30. doi: 10.1186/s13098-023-01002-3.