PMID- 36829478
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230227
IS  - 2079-7737 (Print)
IS  - 2079-7737 (Electronic)
IS  - 2079-7737 (Linking)
VI  - 12
IP  - 2
DP  - 2023 Jan 28
TI  - Tenascin C in Lung Diseases.
LID - 10.3390/biology12020199 [doi]
LID - 199
AB  - Tenascin C (TNC) is a multifunctional large extracellular matrix protein involved 
      in numerous cellular processes in embryonic development and can be increased in 
      disease, or under conditions of trauma or cell stress in adults. However, the 
      role of TNC in lung diseases remains unclear. In this study, we investigated the 
      expression of TNC during development, in offspring following maternal particulate 
      matter (PM) exposure, asthma, chronic obstructive pulmonary disease (COPD) and 
      lung cancer. TNC expression is increased during lung development in biopsy cells, 
      endothelial cells, mesenchymal cells, and epithelial cells. Maternal PM exposure 
      increased TNC and collagen deposition, which was not affected by the removal of 
      PM exposure after pregnancy. TNC expression was also increased in basal 
      epithelial cells and fibroblasts in patients with asthma and AT2 and endothelial 
      cells in patients with COPD. Furthermore, there was an increase in the expression 
      of TNC in stage II compared to stage IA lung cancer; however, overall survival 
      analysis showed no correlation between levels of TNC and survival. In conclusion, 
      TNC is increased during lung development, in offspring following maternal PM 
      exposure, and in asthma, COPD, and lung cancer tissues. Therefore, targeting TNC 
      may provide a novel therapeutic target for lung diseases.
FAU - Donovan, Chantal
AU  - Donovan C
AD  - School of Life Sciences, Faculty of Science, University of Technology Sydney, 
      Sydney, NSW 2007, Australia.
AD  - Hunter Medical Research Institute and The University of Newcastle, Newcastle, NSW 
      2050, Australia.
FAU - Bai, Xu
AU  - Bai X
AD  - School of Life Sciences, Faculty of Science, University of Technology Sydney, 
      Sydney, NSW 2007, Australia.
AD  - Respiratory Cellular and Molecular Biology, Woolcock Institute of Medical 
      Research, Sydney, NSW 2037, Australia.
FAU - Chan, Yik Lung
AU  - Chan YL
AD  - School of Life Sciences, Faculty of Science, University of Technology Sydney, 
      Sydney, NSW 2007, Australia.
FAU - Feng, Min
AU  - Feng M
AD  - School of Life Sciences, Faculty of Science, University of Technology Sydney, 
      Sydney, NSW 2007, Australia.
AD  - Respiratory Cellular and Molecular Biology, Woolcock Institute of Medical 
      Research, Sydney, NSW 2037, Australia.
FAU - Ho, Kin-Fai
AU  - Ho KF
AUID- ORCID: 0000-0001-7464-3437
AD  - Jockey Club School of Public Health and Primary Care, The Chinese University of 
      Hong Kong, Hong Kong SAR 999077, China.
FAU - Guo, Hai
AU  - Guo H
AD  - Air Quality Studies, Department of Civil and Environmental Engineering, Hong Kong 
      Polytechnic University, Hong Kong SAR 999077, China.
FAU - Chen, Hui
AU  - Chen H
AUID- ORCID: 0000-0001-6883-3752
AD  - School of Life Sciences, Faculty of Science, University of Technology Sydney, 
      Sydney, NSW 2007, Australia.
FAU - Oliver, Brian G
AU  - Oliver BG
AUID- ORCID: 0000-0002-7122-9262
AD  - School of Life Sciences, Faculty of Science, University of Technology Sydney, 
      Sydney, NSW 2007, Australia.
AD  - Respiratory Cellular and Molecular Biology, Woolcock Institute of Medical 
      Research, Sydney, NSW 2037, Australia.
LA  - eng
GR  - APP1158186/National Health and Medical Research Council/
GR  - Peter Doherty Fellowship/National Health and Medical Research Council/
GR  - CUHK 14212116/Research Grant Council of The Hong Kong Special Administrative 
      Region China/
GR  - CRF/C5004-15E/RGC of the Hong Kong Special Administrative Region/
GR  - 1-BBW9/the Strategic Focus Area scheme of The Research Institute for Sustainable 
      Urban Development at The Hong Kong Polytechnic University/
PT  - Journal Article
DEP - 20230128
PL  - Switzerland
TA  - Biology (Basel)
JT  - Biology
JID - 101587988
PMC - PMC9953172
OTO - NOTNLM
OT  - COPD
OT  - asthma
OT  - foetal programming
OT  - lung cancer
OT  - lung development
OT  - particular matter
COIS- The authors declare no conflict of interest.
EDAT- 2023/02/26 06:00
MHDA- 2023/02/26 06:01
PMCR- 2023/01/28
CRDT- 2023/02/25 01:03
PHST- 2022/11/16 00:00 [received]
PHST- 2023/01/25 00:00 [revised]
PHST- 2023/01/26 00:00 [accepted]
PHST- 2023/02/25 01:03 [entrez]
PHST- 2023/02/26 06:00 [pubmed]
PHST- 2023/02/26 06:01 [medline]
PHST- 2023/01/28 00:00 [pmc-release]
AID - biology12020199 [pii]
AID - biology-12-00199 [pii]
AID - 10.3390/biology12020199 [doi]
PST - epublish
SO  - Biology (Basel). 2023 Jan 28;12(2):199. doi: 10.3390/biology12020199.