PMID- 36830573
OWN - NLM
STAT- MEDLINE
DCOM- 20230228
LR  - 20230310
IS  - 2218-273X (Electronic)
IS  - 2218-273X (Linking)
VI  - 13
IP  - 2
DP  - 2023 Jan 19
TI  - Oligodendrocyte Progenitors Display Enhanced Proliferation and Autophagy after 
      Space Flight.
LID - 10.3390/biom13020201 [doi]
LID - 201
AB  - Intracranial hypertension (ICP) and visual impairment intracranial pressure 
      (VIIP) are some of the consequences of long-term space missions. Here we examined 
      the behavior of oligodendrocyte progenitors (OLPs) after space flight using 
      time-lapse microscopy. We show that most OLPs divided more than ground control 
      (GC) counterparts did. Nonetheless, a subpopulation of OLPs flown to space 
      presented a significant increase in autophagic cell death. Examination of the 
      proteomic profile of the secretome of space flown OLPs (SPC-OLPs) revealed that 
      the stress protein heat shock protein-90 beta "HSP-90beta" was the 5(th) most 
      enriched (6.8 times) and the secreted protein acidic and rich in cysteine "SPARC" 
      was the 7(th) most enriched (5.2 times), with respect to ground control cells. 
      SPARC induces endoplasmic reticulum stress, which leads to autophagy. Given the 
      roles and importance of these two proteins in mammalian cells' metabolism, their 
      upregulation may hold the key to modulating cell proliferation and autophagy, in 
      order to mitigate ICP and VIIP during and after space missions.
FAU - Tran, Victoria
AU  - Tran V
AD  - Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, 
      The University of California Los Angeles, Los Angeles, CA 90095, USA.
FAU - Carpo, Nicholas
AU  - Carpo N
AD  - Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, 
      The University of California Los Angeles, Los Angeles, CA 90095, USA.
FAU - Cepeda, Carlos
AU  - Cepeda C
AD  - Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, 
      The University of California Los Angeles, Los Angeles, CA 90095, USA.
FAU - Espinosa-Jeffrey, Araceli
AU  - Espinosa-Jeffrey A
AD  - Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, 
      The University of California Los Angeles, Los Angeles, CA 90095, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20230119
PL  - Switzerland
TA  - Biomolecules
JT  - Biomolecules
JID - 101596414
RN  - 0 (Osteonectin)
SB  - IM
MH  - Animals
MH  - Osteonectin
MH  - *Oligodendrocyte Precursor Cells
MH  - Proteomics
MH  - *Space Flight
MH  - Autophagy
MH  - Cell Proliferation
MH  - Mammals
PMC - PMC9953055
OTO - NOTNLM
OT  - HSP-90
OT  - SPARC
OT  - autophagy
OT  - intracranial hypertension
OT  - oligodendrocyte progenitors
OT  - proliferation
OT  - space flight
OT  - visual impairment intracranial pressure
COIS- The authors report no conflict of interest.
EDAT- 2023/02/26 06:00
MHDA- 2023/03/03 06:00
PMCR- 2023/01/19
CRDT- 2023/02/25 01:20
PHST- 2022/12/27 00:00 [received]
PHST- 2023/01/15 00:00 [revised]
PHST- 2023/01/17 00:00 [accepted]
PHST- 2023/02/25 01:20 [entrez]
PHST- 2023/02/26 06:00 [pubmed]
PHST- 2023/03/03 06:00 [medline]
PHST- 2023/01/19 00:00 [pmc-release]
AID - biom13020201 [pii]
AID - biomolecules-13-00201 [pii]
AID - 10.3390/biom13020201 [doi]
PST - epublish
SO  - Biomolecules. 2023 Jan 19;13(2):201. doi: 10.3390/biom13020201.