PMID- 36830649
OWN - NLM
STAT- MEDLINE
DCOM- 20230228
LR  - 20230310
IS  - 2218-273X (Electronic)
IS  - 2218-273X (Linking)
VI  - 13
IP  - 2
DP  - 2023 Feb 2
TI  - Recent Developments in Biopolymer-Based Hydrogels for Tissue Engineering 
      Applications.
LID - 10.3390/biom13020280 [doi]
LID - 280
AB  - Hydrogels are being investigated for their application in inducing the 
      regeneration of various tissues, and suitable conditions for each tissue are 
      becoming more apparent. Conditions such as the mechanical properties, degradation 
      period, degradation mechanism, and cell affinity can be tailored by changing the 
      molecular structure, especially in the case of polymers. Furthermore, many 
      high-functional hydrogels with drug delivery systems (DDSs), in which drugs or 
      bioactive substances are contained in controlled hydrogels, have been reported. 
      This review focuses on the molecular design and function of biopolymer-based 
      hydrogels and introduces recent developments in functional hydrogels for clinical 
      applications.
FAU - Hama, Rikako
AU  - Hama R
AD  - Center for Regenerative Medicine, The Abigail Wexner Research Institute, 
      Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
AD  - Department of Biotechnology and Life Science, Graduate School of Engineering, 
      Tokyo University of Agriculture and Technology, 2-24-16 Naka-Cho, Koganei 
      184-8588, Japan.
FAU - Ulziibayar, Anudari
AU  - Ulziibayar A
AUID- ORCID: 0000-0002-5064-0634
AD  - Center for Regenerative Medicine, The Abigail Wexner Research Institute, 
      Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
FAU - Reinhardt, James W
AU  - Reinhardt JW
AUID- ORCID: 0000-0001-8406-8421
AD  - Center for Regenerative Medicine, The Abigail Wexner Research Institute, 
      Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
FAU - Watanabe, Tatsuya
AU  - Watanabe T
AD  - Center for Regenerative Medicine, The Abigail Wexner Research Institute, 
      Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
FAU - Kelly, John
AU  - Kelly J
AD  - Center for Regenerative Medicine, The Abigail Wexner Research Institute, 
      Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
FAU - Shinoka, Toshiharu
AU  - Shinoka T
AUID- ORCID: 0000-0002-5173-9249
AD  - Center for Regenerative Medicine, The Abigail Wexner Research Institute, 
      Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
AD  - Department of Cardiothoracic Surgery, The Heart Center, Nationwide Children's 
      Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
AD  - Department of Surgery, Cardiovascular Tissue Engineering Program, Ohio State 
      University, Columbus, OH 43210, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230202
PL  - Switzerland
TA  - Biomolecules
JT  - Biomolecules
JID - 101596414
RN  - 0 (Biocompatible Materials)
RN  - 0 (Hydrogels)
RN  - 0 (Biopolymers)
SB  - IM
MH  - *Tissue Engineering
MH  - *Biocompatible Materials/chemistry
MH  - Hydrogels/chemistry
MH  - Biopolymers
MH  - Drug Delivery Systems
PMC - PMC9953003
OTO - NOTNLM
OT  - biodegradation
OT  - chitosan
OT  - collagen
OT  - drug delivery system (DDS)
OT  - elastin
OT  - hydrogel
OT  - proteoglycan
OT  - silk fibroin
OT  - tissue engineering
COIS- The authors declare no conflict of interest.
EDAT- 2023/02/26 06:00
MHDA- 2023/03/03 06:00
PMCR- 2023/02/02
CRDT- 2023/02/25 01:21
PHST- 2022/12/19 00:00 [received]
PHST- 2023/01/16 00:00 [revised]
PHST- 2023/01/30 00:00 [accepted]
PHST- 2023/02/25 01:21 [entrez]
PHST- 2023/02/26 06:00 [pubmed]
PHST- 2023/03/03 06:00 [medline]
PHST- 2023/02/02 00:00 [pmc-release]
AID - biom13020280 [pii]
AID - biomolecules-13-00280 [pii]
AID - 10.3390/biom13020280 [doi]
PST - epublish
SO  - Biomolecules. 2023 Feb 2;13(2):280. doi: 10.3390/biom13020280.