PMID- 36830946
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230228
IS  - 2227-9059 (Print)
IS  - 2227-9059 (Electronic)
IS  - 2227-9059 (Linking)
VI  - 11
IP  - 2
DP  - 2023 Jan 30
TI  - Prevalence of Autoimmune and Autoinflammatory Diseases in Chronic Urticaria: 
      Pathogenetic, Diagnostic and Therapeutic Implications.
LID - 10.3390/biomedicines11020410 [doi]
LID - 410
AB  - Chronic spontaneous urticaria (CSU) is defined as the almost daily occurrence of 
      widespread wheals, angioedema, or both, for more than 6 weeks. It affects 1-2% of 
      the general population, with a higher prevalence in female patients, and is more 
      frequent patients over 20 years of age. More than half of all cases of chronic 
      idiopathic urticaria are thought to occur due to an autoimmune mechanism, 
      specifically the production of autoantibodies against the high-affinity 
      immunoglobulin E (IgE) receptor (FcepsilonRI). The quality of life in these patients is 
      often greatly compromised, also due to the onset of comorbidities represented by 
      other autoimmune diseases, such as thyroid disease, rheumatoid arthritis, 
      systemic lupus erythematosus, Sjogren's syndrome, celiac disease, and type 1 
      diabetes, among others. This review aimed to analyze the close correlation 
      between CSU and some autoimmune and autoinflammatory diseases, in order to 
      encourage a multidisciplinary and multimorbid approach to the patient affected by 
      CSU, which allows not only control of the natural course of the disease, but also 
      any associated comorbidities.
FAU - Murdaca, Giuseppe
AU  - Murdaca G
AUID- ORCID: 0000-0002-6403-6905
AD  - Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy.
AD  - Ospedale Policlinico San Martino IRCCS, 16132 Genoa, Italy.
FAU - Paladin, Francesca
AU  - Paladin F
AD  - Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy.
AD  - Ospedale Policlinico San Martino IRCCS, 16132 Genoa, Italy.
FAU - Borro, Matteo
AU  - Borro M
AUID- ORCID: 0000-0001-9896-506X
AD  - Internal Medicine Department, San Paolo Hospital, 17100 Savona, Italy.
FAU - Ricciardi, Luisa
AU  - Ricciardi L
AUID- ORCID: 0000-0003-3105-8347
AD  - Department of Clinical and Experimental Medicine, School and Operative Unit of 
      Allergy and Clinical Immunology, University of Messina, 98125 Messina, Italy.
FAU - Gangemi, Sebastiano
AU  - Gangemi S
AD  - Department of Clinical and Experimental Medicine, School and Operative Unit of 
      Allergy and Clinical Immunology, University of Messina, 98125 Messina, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230130
PL  - Switzerland
TA  - Biomedicines
JT  - Biomedicines
JID - 101691304
PMC - PMC9953398
OTO - NOTNLM
OT  - autoimmune diseases
OT  - chronic spontaneous urticaria
COIS- The authors declare no conflict of interest.
EDAT- 2023/02/26 06:00
MHDA- 2023/02/26 06:01
PMCR- 2023/01/30
CRDT- 2023/02/25 01:27
PHST- 2022/12/19 00:00 [received]
PHST- 2023/01/24 00:00 [revised]
PHST- 2023/01/28 00:00 [accepted]
PHST- 2023/02/25 01:27 [entrez]
PHST- 2023/02/26 06:00 [pubmed]
PHST- 2023/02/26 06:01 [medline]
PHST- 2023/01/30 00:00 [pmc-release]
AID - biomedicines11020410 [pii]
AID - biomedicines-11-00410 [pii]
AID - 10.3390/biomedicines11020410 [doi]
PST - epublish
SO  - Biomedicines. 2023 Jan 30;11(2):410. doi: 10.3390/biomedicines11020410.