PMID- 36830969
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230228
IS  - 2227-9059 (Print)
IS  - 2227-9059 (Electronic)
IS  - 2227-9059 (Linking)
VI  - 11
IP  - 2
DP  - 2023 Feb 2
TI  - Predictors of DAPSA Response in Psoriatic Arthritis Patients Treated with 
      Apremilast in a Retrospective Observational Multi-Centric Study.
LID - 10.3390/biomedicines11020433 [doi]
LID - 433
AB  - BACKGROUND: To date, only a few real-world-setting studies evaluated apremilast 
      effectiveness in psoriatic arthritis (PsA). The aims of this retrospective 
      observational study are to report long-term Disease Activity Index for Psoriatic 
      Arthritis (DAPSA) response of apremilast in PsA patients and to analyze the 
      predictors of clinical response. METHODS: All PsA consecutive patients treated 
      with apremilast in fifteen Italian rheumatological referral centers were 
      enrolled. Anamnestic data, treatment history, and PsA disease activity (DAPSA) at 
      baseline, 6 months, and 12 months were recorded. The Mann-Whitney test and 
      chi-squared tests assessed the differences between independent groups, whereas 
      the Wilcoxon matched pairs signed-rank test assessed the differences between 
      dependent samples. Logistic regressions verified if there were factors associated 
      with achievement of DAPSA low disease activity or remission at 6 and 12 months. 
      RESULTS: DAPSA low disease activity or remission rates at 6 and 12 months were 
      observed, respectively, in 42.7% (n = 125) and 54.9% (n = 161) patients. Baseline 
      DAPSA was inversely associated with the odds of achieving low disease activity or 
      remission at 6 months (odds ratio (OR) 0.841, 95% confidence interval (CI) 
      0.804-0.879; p < 0.01) and at 12 months (OR 0.911, 95% CI 0.883-0.939; p < 0.01). 
      CONCLUSIONS: Almost half of the PsA patients receiving apremilast achieved DAPSA 
      low disease activity or remission at 6 and 12 months. The only factor associated 
      with achievement of low disease activity or remission at both 6 and 12 months was 
      baseline DAPSA.
FAU - Becciolini, Andrea
AU  - Becciolini A
AUID- ORCID: 0000-0002-1051-8511
AD  - Internal Medicine and Rheumatology Unit, Department of Medicine, University 
      Hospital of Parma, 43121 Parma, Italy.
FAU - Parisi, Simone
AU  - Parisi S
AUID- ORCID: 0000-0003-4496-8315
AD  - Rheumatology Unit, Department of General and Specialistic Medicine, Azienda 
      Ospedaliera Universitaria, Citta della Salute e della Scienza di Torino, 10121 
      Turin, Italy.
FAU - Del Medico, Patrizia
AU  - Del Medico P
AD  - Rheumatology Outpatient Clinic, Internal Medicine Unit, Civitanova Marche 
      Hospital, 62012 Civitanova Marche, Italy.
FAU - Farina, Antonella
AU  - Farina A
AD  - Internal Medicine Unit, Rheumatology Outpatient Clinic, Ospedale "A. Murri", 
      63900 Fermo, Italy.
FAU - Visalli, Elisa
AU  - Visalli E
AD  - Rheumatology Unit, Policlinico San Marco University Hospital of Catania, 95121 
      Catania, Italy.
FAU - Molica Colella, Aldo Biagio
AU  - Molica Colella AB
AUID- ORCID: 0000-0002-7238-7879
AD  - Rheumatology Unit, Azienda Ospedaliera Papardo, 98158 Messina, Italy.
FAU - Lumetti, Federica
AU  - Lumetti F
AD  - Rheumatology Unit, Azienda USL of Modena and AOU Policlinico of Modena, 41100 
      Modena, Italy.
FAU - Caccavale, Rosalba
AU  - Caccavale R
AD  - Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University 
      of Rome, Polo Pontino, 04100 Latina, Italy.
FAU - Scolieri, Palma
AU  - Scolieri P
AUID- ORCID: 0000-0002-2055-7282
AD  - Unit of Internal Medicine and Rheumatology, "Nuovo Regina Margherita/S. Spirito" 
      Hospital, ASL Roma 1, 00153 Rome, Italy.
FAU - Andracco, Romina
AU  - Andracco R
AD  - Distretto Socio Sanitario ASL 1 Imperiese, 18100 Imperia, Italy.
FAU - Girelli, Francesco
AU  - Girelli F
AD  - Rheumatology Service, Internal Medicine Unit, GB Morgagni Hospital, 47121 Forli, 
      Italy.
FAU - Bravi, Elena
AU  - Bravi E
AD  - Rheumatology Unit, Ospedale Guglielmo da Saliceto, 29121 Piacenza, Italy.
FAU - Colina, Matteo
AU  - Colina M
AD  - Rheumatology Service, Section of Internal Medicine, Department of Medicine and 
      Oncology, Ospedale Santa Maria della Scaletta, 40026 Imola, Italy.
AD  - Alma Mater Studiorum, Department of Biomedical and Neuromotor Sciences, 
      University of Bologna, 40126 Bologna, Italy.
FAU - Volpe, Alessandro
AU  - Volpe A
AD  - Rheumatology Unit, IRCCS Sacro Cuore Don Calabria, 37024 Bologna, Italy.
FAU - Ianniello, Aurora
AU  - Ianniello A
AD  - Rheumatology Outpatient Unit, ASL Novara, 28100 Novara, Italy.
FAU - Ditto, Maria Chiara
AU  - Ditto MC
AUID- ORCID: 0000-0001-5025-287X
AD  - Rheumatology Unit, Department of General and Specialistic Medicine, Azienda 
      Ospedaliera Universitaria, Citta della Salute e della Scienza di Torino, 10121 
      Turin, Italy.
FAU - Nucera, Valeria
AU  - Nucera V
AD  - Rheumatology Outpatient Unit, ASL Novara, 28100 Novara, Italy.
FAU - Franchina, Veronica
AU  - Franchina V
AD  - UOC Oncologia Medica Azienda Ospedaliera Papardo, 98158 Messina, Italy.
FAU - Plate, Ilaria
AU  - Plate I
AD  - Rheumatology Unit, Ospedale Guglielmo da Saliceto, 29121 Piacenza, Italy.
FAU - Donato, Eleonora Di
AU  - Donato ED
AUID- ORCID: 0000-0002-5466-3446
AD  - Internal Medicine and Rheumatology Unit, Department of Medicine, University 
      Hospital of Parma, 43121 Parma, Italy.
FAU - Amato, Giorgio
AU  - Amato G
AD  - Rheumatology Unit, Policlinico San Marco University Hospital of Catania, 95121 
      Catania, Italy.
FAU - Salvarani, Carlo
AU  - Salvarani C
AD  - Rheumatology Unit, University of Modena and Reggio Emilia, 41100 Modena, Italy.
FAU - Bernardi, Simone
AU  - Bernardi S
AD  - Rheumatology Service, Internal Medicine Unit, GB Morgagni Hospital, 47121 Forli, 
      Italy.
FAU - Lucchini, Gianluca
AU  - Lucchini G
AD  - Internal Medicine and Rheumatology Unit, Department of Medicine, University 
      Hospital of Parma, 43121 Parma, Italy.
FAU - De Lucia, Francesco
AU  - De Lucia F
AD  - Rheumatology Unit, Policlinico San Marco University Hospital of Catania, 95121 
      Catania, Italy.
FAU - Molica Colella, Francesco
AU  - Molica Colella F
AD  - Internal Medicine Unit, University Bicocca Milan, 20126 Milano, Italy.
FAU - Santilli, Daniele
AU  - Santilli D
AD  - Internal Medicine and Rheumatology Unit, Department of Medicine, University 
      Hospital of Parma, 43121 Parma, Italy.
FAU - Mansueto, Natalia
AU  - Mansueto N
AD  - Distretto Socio Sanitario ASL 1 Imperiese, 18100 Imperia, Italy.
FAU - Ferrero, Giulio
AU  - Ferrero G
AD  - Unit of Diagnostic and Interventional Radiology, Santa Corona Hospital, 17027 
      Pietra Ligure, Italy.
FAU - Marchetta, Antonio
AU  - Marchetta A
AD  - Rheumatology Unit, IRCCS Sacro Cuore Don Calabria, 37024 Bologna, Italy.
FAU - Arrigoni, Eugenio
AU  - Arrigoni E
AD  - Rheumatology Unit, Ospedale Guglielmo da Saliceto, 29121 Piacenza, Italy.
FAU - Foti, Rosario
AU  - Foti R
AD  - Rheumatology Unit, Policlinico San Marco University Hospital of Catania, 95121 
      Catania, Italy.
FAU - Sandri, Gilda
AU  - Sandri G
AUID- ORCID: 0000-0003-0454-1093
AD  - Rheumatology Unit, University of Modena and Reggio Emilia, 41100 Modena, Italy.
FAU - Bruzzese, Vincenzo
AU  - Bruzzese V
AD  - Unit of Internal Medicine and Rheumatology, "Nuovo Regina Margherita/S. Spirito" 
      Hospital, ASL Roma 1, 00153 Rome, Italy.
FAU - Paroli, Marino
AU  - Paroli M
AUID- ORCID: 0000-0001-7919-9128
AD  - Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University 
      of Rome, Polo Pontino, 04100 Latina, Italy.
FAU - Fusaro, Enrico
AU  - Fusaro E
AUID- ORCID: 0000-0001-9888-2563
AD  - Rheumatology Unit, Department of General and Specialistic Medicine, Azienda 
      Ospedaliera Universitaria, Citta della Salute e della Scienza di Torino, 10121 
      Turin, Italy.
FAU - Ariani, Alarico
AU  - Ariani A
AUID- ORCID: 0000-0003-1428-6102
AD  - Internal Medicine and Rheumatology Unit, Department of Medicine, University 
      Hospital of Parma, 43121 Parma, Italy.
LA  - eng
PT  - Journal Article
DEP - 20230202
PL  - Switzerland
TA  - Biomedicines
JT  - Biomedicines
JID - 101691304
PMC - PMC9953385
OTO - NOTNLM
OT  - DAPSA
OT  - apremilast
OT  - psoriatic arthritis
COIS- The authors declare no conflict of interest.
EDAT- 2023/02/26 06:00
MHDA- 2023/02/26 06:01
PMCR- 2023/02/02
CRDT- 2023/02/25 01:28
PHST- 2022/12/31 00:00 [received]
PHST- 2023/01/29 00:00 [revised]
PHST- 2023/01/31 00:00 [accepted]
PHST- 2023/02/25 01:28 [entrez]
PHST- 2023/02/26 06:00 [pubmed]
PHST- 2023/02/26 06:01 [medline]
PHST- 2023/02/02 00:00 [pmc-release]
AID - biomedicines11020433 [pii]
AID - biomedicines-11-00433 [pii]
AID - 10.3390/biomedicines11020433 [doi]
PST - epublish
SO  - Biomedicines. 2023 Feb 2;11(2):433. doi: 10.3390/biomedicines11020433.