PMID- 36831072
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230228
IS  - 2227-9059 (Print)
IS  - 2227-9059 (Electronic)
IS  - 2227-9059 (Linking)
VI  - 11
IP  - 2
DP  - 2023 Feb 13
TI  - The Influence of Adipokines on Radiographic Damage in Inflammatory Rheumatic 
      Diseases.
LID - 10.3390/biomedicines11020536 [doi]
LID - 536
AB  - Inflammatory rheumatic diseases (IRDs) are complex immune-mediated diseases that 
      are characterized by chronic inflammation of the joints. Rheumatoid arthritis 
      (RA) and spondyloarthritis (SpA), including axial SpA (ax SpA) and psoriatic 
      arthritis (PsA), are the most common forms of IRD. Both RA and ax SpA are 
      characterized by a chronic course with progressive structural modifications, 
      namely, cartilage damage and bone erosions in RA and osteoproliferative changes 
      with spinal ossifications in ax SpA. The adipose tissue is involved in the 
      pathophysiology of IRDs via the release of several proteins, namely, adipokines. 
      Several adipokines with pro-inflammatory effects have been identified, such as 
      leptin, adiponectin, visfatin and resistin. In this review, we discuss the role 
      that adipokines may play in the structural modifications of the peripheral joints 
      and/or axial skeleton. In RA, the role of leptin in structural damage remains 
      controversial, while adiponectin and its high-molecular-weight isoform are known 
      to have an influence on the development of bone erosions and radiographic 
      progression. Resistin also appears to be a potent detrimental adipokine for the 
      joints in RA. In ax SpA, visfatin seems to be an attractive candidate for 
      radiographic progression, while leptin and adiponectin have negative effects on 
      radiographic progression.
FAU - Toussirot, Eric
AU  - Toussirot E
AUID- ORCID: 0000-0002-6228-1464
AD  - INSERM CIC-1431, Centre d'Investigation Clinique Biotherapie, Pole Recherche, CHU 
      de Besancon, 25000 Besancon, France.
AD  - INSERM UMR1098 "Relations Hote Greffon Tumeurs, Ingenierie Cellulaire et 
      Genique", Universite de Franche-Comte, 25000 Besancon, France.
AD  - Rhumatologie, Pole PACTE (Pathologies Aigues Chroniques Transplantation 
      Education), CHU de Besancon, 25000 Besancon, France.
AD  - Departement Universitaire de Therapeutique, Universite de Franche-Comte, 25000 
      Besancon, France.
LA  - eng
GR  - API/2013/37/CHU de Besancon/
PT  - Journal Article
PT  - Review
DEP - 20230213
PL  - Switzerland
TA  - Biomedicines
JT  - Biomedicines
JID - 101691304
PMC - PMC9953013
OTO - NOTNLM
OT  - adipokines
OT  - axial spondyloarthritis
OT  - bone erosion
OT  - rheumatoid arthritis
OT  - syndesmophyte
COIS- The author declares no conflict of interest.
EDAT- 2023/02/26 06:00
MHDA- 2023/02/26 06:01
PMCR- 2023/02/13
CRDT- 2023/02/25 01:30
PHST- 2023/01/11 00:00 [received]
PHST- 2023/02/06 00:00 [revised]
PHST- 2023/02/10 00:00 [accepted]
PHST- 2023/02/25 01:30 [entrez]
PHST- 2023/02/26 06:00 [pubmed]
PHST- 2023/02/26 06:01 [medline]
PHST- 2023/02/13 00:00 [pmc-release]
AID - biomedicines11020536 [pii]
AID - biomedicines-11-00536 [pii]
AID - 10.3390/biomedicines11020536 [doi]
PST - epublish
SO  - Biomedicines. 2023 Feb 13;11(2):536. doi: 10.3390/biomedicines11020536.