PMID- 36831570
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230228
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 15
IP  - 4
DP  - 2023 Feb 15
TI  - Kisspeptin and GPR54 Receptor Expression in Endometrial Cancer Tissue.
LID - 10.3390/cancers15041228 [doi]
LID - 1228
AB  - Kisspeptin (KISS) is a natural peptide-discovered in 1996 as a factor inhibiting 
      the ability to metastasize in malignant melanoma. This protein plays also a 
      regulatory role in the process of puberty, the menstrual cycle, spermatogenesis, 
      implantation and development of the human placenta. The present study aimed to 
      evaluate the expression of KISS and its receptor GPR54 in endometrial cancer (EC) 
      tissue, depending on the histological type of cancer, its stage, various 
      demographic characteristics, and clinical conditions in 214 hysterectomy 
      patients. Expression of KISS and GPR54 was confirmed in 99.5% and 100% of the 
      cases, respectively. Hormone replacement therapy and the coexistence of the 
      anti-Mullerian type 2 receptor in cancer tissue enhanced KISS expression. 
      Smoking, on the other hand, decreased KISS expression. GPR54 expression increased 
      with the advancement of the disease (according to FIGO classification). Also, the 
      presence of the anti-Mullerian type 2 receptor in EC increased the level of 
      GPR54. Hypertension, age and miscarriage harmed the presence of GPR54. The 
      histological type of cancer, diabetes type 2, body mass index, hormonal 
      contraception, number of deliveries, birth weight of newborns, breastfeeding 
      time, and the presence of AMH in EC tissue were not associated with the 
      expression of either KISS nor GPR54. The KISS level was also significantly 
      related to the GPR54 level. Considering that KISS is a non-toxic peptide with 
      antimetastatic properties, further investigation is essential to determine the 
      clinical significance of this peptide.
FAU - Gowkielewicz, Marek
AU  - Gowkielewicz M
AUID- ORCID: 0000-0002-3868-1679
AD  - Department of Gynecology and Obstetrics, School of Medicine, Collegium Medicum, 
      University of Warmia and Mazury in Olsztyn, 10-045 Olsztyn, Poland.
FAU - Lipka, Aleksandra
AU  - Lipka A
AUID- ORCID: 0000-0003-0815-6635
AD  - Department of Gynecology and Obstetrics, School of Medicine, Collegium Medicum, 
      University of Warmia and Mazury in Olsztyn, 10-045 Olsztyn, Poland.
FAU - Piotrowska, Aleksandra
AU  - Piotrowska A
AUID- ORCID: 0000-0003-4093-7386
AD  - Division of Histology and Embryology, Department of Human Morphology and 
      Embryology, Wroclaw Medical University, Chalubinskiego Street 6a, 50-368 Wroclaw, 
      Poland.
FAU - Szadurska-Noga, Marta
AU  - Szadurska-Noga M
AD  - Department of Pathomorphology, School of Medicine, Collegium Medicum, University 
      of Warmia and Mazury in Olsztyn, 10-561 Olsztyn, Poland.
FAU - Nowakowski, Jacek J
AU  - Nowakowski JJ
AUID- ORCID: 0000-0001-9475-2868
AD  - Department of Ecology & Environmental Protection, University of Warmia and Mazury 
      in Olsztyn, Plac Lodzki 3, 10-727 Olsztyn, Poland.
FAU - Lepiarczyk, Ewa
AU  - Lepiarczyk E
AUID- ORCID: 0000-0003-2998-9468
AD  - Department of Human Physiology, School of Medicine, Collegium Medicum, University 
      of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland.
FAU - Wiszpolska, Marta
AU  - Wiszpolska M
AD  - Department of Human Physiology, School of Medicine, Collegium Medicum, University 
      of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland.
FAU - Wasniewski, Tomasz
AU  - Wasniewski T
AD  - Department of Gynecology and Obstetrics, School of Medicine, Collegium Medicum, 
      University of Warmia and Mazury in Olsztyn, 10-045 Olsztyn, Poland.
FAU - Dziegiel, Piotr
AU  - Dziegiel P
AUID- ORCID: 0000-0002-8292-1385
AD  - Division of Histology and Embryology, Department of Human Morphology and 
      Embryology, Wroclaw Medical University, Chalubinskiego Street 6a, 50-368 Wroclaw, 
      Poland.
AD  - Division of Human Biology, Faculty of Physiotherapy, University School of 
      Physical Education in Wroclaw, 51-612 Wroclaw, Poland.
FAU - Kaleczyc, Jerzy
AU  - Kaleczyc J
AUID- ORCID: 0000-0001-8617-6039
AD  - Department of Animal Anatomy, Faculty of Veterinary Medicine, University of 
      Warmia and Mazury, Oczapowskiego 13, 10-719 Olsztyn, Poland.
FAU - Majewski, Mariusz Krzysztof
AU  - Majewski MK
AUID- ORCID: 0000-0001-5818-7689
AD  - Department of Human Physiology, School of Medicine, Collegium Medicum, University 
      of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland.
FAU - Majewska, Marta
AU  - Majewska M
AUID- ORCID: 0000-0001-5856-6929
AD  - Department of Human Physiology, School of Medicine, Collegium Medicum, University 
      of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland.
LA  - eng
GR  - 2021/05/X/NZ4/01236/National Science Center/
PT  - Journal Article
DEP - 20230215
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC9954558
OTO - NOTNLM
OT  - AMH
OT  - AMHRII
OT  - GPR54
OT  - KISS
OT  - endometrial cancer
COIS- The authors declare no conflict of interest.
EDAT- 2023/02/26 06:00
MHDA- 2023/02/26 06:01
PMCR- 2023/02/15
CRDT- 2023/02/25 01:40
PHST- 2022/12/07 00:00 [received]
PHST- 2023/01/27 00:00 [revised]
PHST- 2023/02/11 00:00 [accepted]
PHST- 2023/02/25 01:40 [entrez]
PHST- 2023/02/26 06:00 [pubmed]
PHST- 2023/02/26 06:01 [medline]
PHST- 2023/02/15 00:00 [pmc-release]
AID - cancers15041228 [pii]
AID - cancers-15-01228 [pii]
AID - 10.3390/cancers15041228 [doi]
PST - epublish
SO  - Cancers (Basel). 2023 Feb 15;15(4):1228. doi: 10.3390/cancers15041228.