PMID- 36832096
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230228
IS  - 2075-4418 (Print)
IS  - 2075-4418 (Electronic)
IS  - 2075-4418 (Linking)
VI  - 13
IP  - 4
DP  - 2023 Feb 7
TI  - Comparative Study of the Impact of Human Leukocyte Antigens on Renal Transplant 
      Survival in Andalusia and the United States.
LID - 10.3390/diagnostics13040608 [doi]
LID - 608
AB  - Renal transplantation is the treatment of choice for patients suffering from 
      chronic renal disease, one of the leading causes of death worldwide. Among the 
      biological barriers that may increase the risk of acute renal graft rejection is 
      the presence of human leukocyte antigen (HLA) incompatibilities between donor and 
      recipient. This work presents a comparative study of the influence of HLA 
      incompatibilities on renal transplantation survival in the Andalusian (South of 
      Spain) and United States (US) population. The main objective is to analyse the 
      extent to which results about the influence of different factors on renal graft 
      survival can be generalised to different populations. The Kaplan-Meier estimator 
      and the Cox model have been used to identify and quantify the impact on the 
      survival probability of HLA incompatibilities, both in isolation and in 
      conjunction with other factors associated with the donor and recipient. According 
      to the results obtained, HLA incompatibilities considered in isolation have 
      negligible impact on renal survival in the Andalusian population and a moderate 
      impact in the US population. Grouping by HLA score presents some similarities for 
      both populations, while the sum of all HLA scores (aHLA) only has an impact on 
      the US population. Finally, the graft survival probability of the two populations 
      differs when aHLA is considered in conjunction with blood type. The results 
      suggest that the disparities in the renal graft survival probability between the 
      two populations under study are due not only to biological and 
      transplantation-associated factors, but also to social-health factors and ethnic 
      heterogeneity between populations.
FAU - Talaminos Barroso, Alejandro
AU  - Talaminos Barroso A
AUID- ORCID: 0000-0002-5047-5296
AD  - Biomedical Engineering Group, Department of Signal Theory and Communications, 
      University of Seville, 41004 Seville, Spain.
FAU - Reina Tosina, Javier
AU  - Reina Tosina J
AUID- ORCID: 0000-0002-6853-4899
AD  - Biomedical Engineering Group, Department of Signal Theory and Communications, 
      University of Seville, 41004 Seville, Spain.
AD  - Department of Signal Theory and Communications, University of Seville, 41004 
      Seville, Spain.
FAU - Roa, Laura M
AU  - Roa LM
AD  - Biomedical Engineering Group, Department of Signal Theory and Communications, 
      University of Seville, 41004 Seville, Spain.
FAU - Calvillo Arbizu, Jorge
AU  - Calvillo Arbizu J
AUID- ORCID: 0000-0003-1277-3310
AD  - Biomedical Engineering Group, Department of Signal Theory and Communications, 
      University of Seville, 41004 Seville, Spain.
AD  - Department of Telematics Engineering, University of Seville, 41004 Seville, 
      Spain.
FAU - Perez Valdivia, Miguel Angel
AU  - Perez Valdivia MA
AD  - Urology and Nephrology Department, University Hospital Virgen del Rocio, 41012 
      Seville, Spain.
FAU - Medina, Rafael
AU  - Medina R
AD  - Urology and Nephrology Department, University Hospital Virgen del Rocio, 41012 
      Seville, Spain.
FAU - Rocha Castilla, Jose Luis
AU  - Rocha Castilla JL
AUID- ORCID: 0000-0003-2650-1914
AD  - Urology and Nephrology Department, University Hospital Virgen del Rocio, 41012 
      Seville, Spain.
FAU - Castro-de-la-Nuez, Pablo
AU  - Castro-de-la-Nuez P
AD  - Autonomous Regional Transplant Coordination in Andalusia, 41012 Seville, Spain.
LA  - eng
PT  - Journal Article
DEP - 20230207
PL  - Switzerland
TA  - Diagnostics (Basel)
JT  - Diagnostics (Basel, Switzerland)
JID - 101658402
PMC - PMC9954912
OTO - NOTNLM
OT  - blood type
OT  - human leukocyte antigens
OT  - renal transplantation
OT  - socio-economic factors
OT  - survival analysis
COIS- The authors declare no conflict of interest.
EDAT- 2023/02/26 06:00
MHDA- 2023/02/26 06:01
PMCR- 2023/02/07
CRDT- 2023/02/25 01:49
PHST- 2022/11/08 00:00 [received]
PHST- 2023/01/23 00:00 [revised]
PHST- 2023/01/27 00:00 [accepted]
PHST- 2023/02/25 01:49 [entrez]
PHST- 2023/02/26 06:00 [pubmed]
PHST- 2023/02/26 06:01 [medline]
PHST- 2023/02/07 00:00 [pmc-release]
AID - diagnostics13040608 [pii]
AID - diagnostics-13-00608 [pii]
AID - 10.3390/diagnostics13040608 [doi]
PST - epublish
SO  - Diagnostics (Basel). 2023 Feb 7;13(4):608. doi: 10.3390/diagnostics13040608.