PMID- 36832980
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230228
IS  - 2304-8158 (Print)
IS  - 2304-8158 (Electronic)
IS  - 2304-8158 (Linking)
VI  - 12
IP  - 4
DP  - 2023 Feb 20
TI  - Chemometric Discrimination of Cichorium glandulosum Boiss. et Huet and Cichorium 
      intybus L. via Their Metabolic Profiling, Antioxidative, and Hypoglycemic 
      Activities.
LID - 10.3390/foods12040901 [doi]
LID - 901
AB  - Cichorium glandulosum Boiss. et Huet (CG) and Cichorium intybus L. (CI) are 
      widely used as the main raw material of functional food with hepatoprotective and 
      hypoglycemic effects. Due to the lack of comparison on the chemical ingredients 
      and efficacy, they were often used imprecisely and interchangeably. It is 
      necessary to distinguish between them. With the plant metabolomics based on 
      high-performance liquid chromatography coupled with quadrupole time-of-flight 
      mass spectrometry (HPLC-QTOF-MS) and multivariate chemometric techniques, the 
      chemical ingredients were characterized and 59 compounds between CG and CI were 
      classified. As for antioxidative and hypoglycemic activities in vitro, CI 
      extraction exhibited better antioxidant activity than CG, while CG extraction 
      showed stronger hypoglycemic activity. Furthermore, a bivariate correlation 
      between the chemical composition and efficacy of the extract was also analyzed, 
      and three differentially strong correlation components between CI and CG were 
      prepared, and the antioxidative and hypoglycemic efficacies were compared in vivo 
      and different active phenotypes were obtained. Finally, we revealed chemical and 
      biological differences between CG and CI, providing a basis for achieving better 
      quality control and developing more effective functional foods.
FAU - Li, Maoru
AU  - Li M
AD  - Jiangsu Key Laboratory of TCM Evaluation and Translation Research, School of 
      Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, 
      China.
FAU - Xie, Guoyong
AU  - Xie G
AD  - Department of Resources Science of Traditional Chinese Medicines, School of 
      Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, 
      China.
FAU - Ding, Yadong
AU  - Ding Y
AD  - Jiangsu Key Laboratory of TCM Evaluation and Translation Research, School of 
      Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, 
      China.
FAU - Ma, Ji
AU  - Ma J
AUID- ORCID: 0000-0003-4608-3908
AD  - Jiangsu Key Laboratory of TCM Evaluation and Translation Research, School of 
      Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, 
      China.
FAU - Liu, Qiuyan
AU  - Liu Q
AD  - Jiangsu Key Laboratory of TCM Evaluation and Translation Research, School of 
      Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, 
      China.
FAU - Wang, Yuqin
AU  - Wang Y
AD  - Jiangsu Key Laboratory of TCM Evaluation and Translation Research, School of 
      Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, 
      China.
FAU - Peng, Zan
AU  - Peng Z
AD  - Jiangsu Key Laboratory of TCM Evaluation and Translation Research, School of 
      Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, 
      China.
FAU - Sun, Jianbo
AU  - Sun J
AD  - Department of Natural Medicinal Chemistry, China Pharmaceutical University, 
      Nanjing 211198, China.
FAU - Shang, Jing
AU  - Shang J
AD  - Jiangsu Key Laboratory of TCM Evaluation and Translation Research, School of 
      Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, 
      China.
LA  - eng
GR  - 2019ZX09301-156/National Science Technology Major Project of China/
PT  - Journal Article
DEP - 20230220
PL  - Switzerland
TA  - Foods
JT  - Foods (Basel, Switzerland)
JID - 101670569
PMC - PMC9957518
OTO - NOTNLM
OT  - Cichorium glandulosum Boiss. et Huet
OT  - Cichorium intybus L.
OT  - HPLC-QTOF-MS
OT  - activity comparison
OT  - plant metabolomics
COIS- The authors declare no conflict of interest.
EDAT- 2023/02/26 06:00
MHDA- 2023/02/26 06:01
PMCR- 2023/02/20
CRDT- 2023/02/25 02:07
PHST- 2023/01/17 00:00 [received]
PHST- 2023/02/15 00:00 [revised]
PHST- 2023/02/18 00:00 [accepted]
PHST- 2023/02/25 02:07 [entrez]
PHST- 2023/02/26 06:00 [pubmed]
PHST- 2023/02/26 06:01 [medline]
PHST- 2023/02/20 00:00 [pmc-release]
AID - foods12040901 [pii]
AID - foods-12-00901 [pii]
AID - 10.3390/foods12040901 [doi]
PST - epublish
SO  - Foods. 2023 Feb 20;12(4):901. doi: 10.3390/foods12040901.