PMID- 36833019
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230228
IS  - 2227-9032 (Print)
IS  - 2227-9032 (Electronic)
IS  - 2227-9032 (Linking)
VI  - 11
IP  - 4
DP  - 2023 Feb 7
TI  - Allelic Discrimination of Vitamin D Receptor Polymorphisms and Risk of Type 2 
      Diabetes Mellitus: A Case-Controlled Study.
LID - 10.3390/healthcare11040485 [doi]
LID - 485
AB  - (1) Background: Type 2 diabetes mellitus (T2DM) is one of the rapidly growing 
      healthcare problems, and several vitamin D receptor (VDR) polymorphisms seem to 
      modulate the risk of T2DM. Our research was designed to investigate the allelic 
      discrimination of VDR polymorphisms and T2DM occurrence risk. (2) Methods: This 
      case-control research included 156 patients with T2DM and 145 healthy control 
      subjects. Most of the study population were males 56.6% vs. 62.8% in the case and 
      control groups, respectively. Genotyping for VDR single nucleotide polymorphisms 
      (SNPs), rs228570 (Fok1), rs7975232 (Apa1), and rs1544410 (Bsm1) was compared 
      between both groups. (3) Results: There was a negative link between vitamin D 
      levels and insulin sensitivity. A significant difference was noted in the allelic 
      discrimination of VDR polymorphism rs228570 and rs1544410 between the study 
      groups (p < 0.001). No difference was observed in the allelic discrimination of 
      VDR polymorphism rs7975232 between the groups (p = 0.063). Moreover, T2DM 
      patients had significantly higher levels of fasting blood sugar (FBS), glycated 
      hemoglobin HbA1c, 2-h post-prandial blood sugar (PP), serum glutamic oxaloacetic 
      transaminase (SGOT), serum glutamic-pyruvic transaminase (SGPT), total 
      cholesterol, and triglycerides (p < 0.001), while High-Density Lipoprotein (HDL) 
      Cholesterol (HDL-C) was significantly decreased (p = 0.006). (4) Conclusions: VDR 
      polymorphisms had a positive association with T2DM risk among the Egyptian 
      population. Further large-scale research using deep sequencing of samples is 
      strongly urged to investigate different vitamin D gene variants and interactions, 
      as well as the influence of vitamin D on T2DM.
FAU - Mohammed, Amal Ahmed
AU  - Mohammed AA
AD  - Department of Biochemistry and Molecular Biology, National Hepatology and 
      Tropical Medicine Research Institute (NHTMRI), Cairo 11796, Egypt.
FAU - El-Matty, Dina M Abo
AU  - El-Matty DMA
AD  - Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia 
      41522, Egypt.
FAU - Abdel-Azeem, Rola
AU  - Abdel-Azeem R
AD  - Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia 
      41522, Egypt.
FAU - Raafat, Khaled
AU  - Raafat K
AD  - Department of Internal Medicine, Faculty of Medicine, Ain Shams University, 
      Cairo11566, Egypt.
FAU - Hussein, Mona A
AU  - Hussein MA
AD  - Department of Internal Medicine, National Institute of Diabetes and 
      Endocrinology, Cairo 11562, Egypt.
FAU - El-Ansary, Amira R
AU  - El-Ansary AR
AD  - Department of Internal Medicine, Faculty of Medicine, Misr University for Science 
      and Technology, Giza 12577, Egypt.
FAU - Hafez, Wael
AU  - Hafez W
AUID- ORCID: 0000-0003-1203-0808
AD  - Department of Internal Medicine, The National Research Centre, Cairo 12622, 
      Egypt.
FAU - Hassan, Hatem Ahmed
AU  - Hassan HA
AD  - Department of Internal Medicine and Gastroenterology, Faculty of Medicine, Minia 
      University, Minia 61519, Egypt.
FAU - Nassar, Nourelhuda Ahmed
AU  - Nassar NA
AD  - Clinical Pathology Department, Elsahel Teaching Hospital, Cairo 11697, Egypt.
FAU - Selim, Nora Mahmoud
AU  - Selim NM
AD  - Department of Clinical and Chemical Pathology Department, Faculty of Medicine, 
      Cairo University, Cairo 12613, Egypt.
FAU - Ghaith, Doaa
AU  - Ghaith D
AD  - Department of Clinical and Chemical Pathology Department, Faculty of Medicine, 
      Cairo University, Cairo 12613, Egypt.
FAU - Kholy, Amal A El
AU  - Kholy AAE
AUID- ORCID: 0000-0003-4917-6392
AD  - Department of Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo 
      11566, Egypt.
FAU - Abd El Salam, Soha M
AU  - Abd El Salam SM
AD  - Department of Medical Microbiology and Immunology, Faculty of Medicine, Suez 
      University, Suez 43512, Egypt.
FAU - Anouti, Fatme Al
AU  - Anouti FA
AUID- ORCID: 0000-0002-1993-6656
AD  - Department of Health Sciences, College of Natural and Health Sciences, Zayed 
      University, Abu Dhabi 144534, United Arab Emirates.
FAU - Wahba, Alaa S
AU  - Wahba AS
AUID- ORCID: 0000-0002-2600-9965
AD  - Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia 
      41522, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20230207
PL  - Switzerland
TA  - Healthcare (Basel)
JT  - Healthcare (Basel, Switzerland)
JID - 101666525
PMC - PMC9956945
OTO - NOTNLM
OT  - T2DM
OT  - allelic discrimination
OT  - polymorphism
OT  - vitamin D receptor
COIS- The authors declare no conflict of interest.
EDAT- 2023/02/26 06:00
MHDA- 2023/02/26 06:01
PMCR- 2023/02/07
CRDT- 2023/02/25 02:07
PHST- 2022/12/29 00:00 [received]
PHST- 2023/02/02 00:00 [revised]
PHST- 2023/02/02 00:00 [accepted]
PHST- 2023/02/25 02:07 [entrez]
PHST- 2023/02/26 06:00 [pubmed]
PHST- 2023/02/26 06:01 [medline]
PHST- 2023/02/07 00:00 [pmc-release]
AID - healthcare11040485 [pii]
AID - healthcare-11-00485 [pii]
AID - 10.3390/healthcare11040485 [doi]
PST - epublish
SO  - Healthcare (Basel). 2023 Feb 7;11(4):485. doi: 10.3390/healthcare11040485.