PMID- 3683348
OWN - NLM
STAT- MEDLINE
DCOM- 19880111
LR  - 20190919
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 9
IP  - 4
DP  - 1987 Jul-Aug
TI  - Abnormal heart rate tracings and serum creatine phosphokinase in addicted 
      neonates.
PG  - 305-9
AB  - Continuous cardiorespirographic (CRG) monitoring was done during the first five 
      postnatal days in 12 infants of drug dependent mothers (IDDM) and 19 normal 
      infants (control). Abnormal heart rate patterns in the IDDM included: (1) 
      significantly (p less than 0.01) higher baseline heart rate (129 +/- 15 vs. 118 
      +/- 8), beat-to-beat variability (4.4 +/- 2.4 vs. 2.6 +/- 1.6) and long-term 
      variability (15.5 +/- 6.6 vs. 7.0 +/- 3.9), as compared to control and (2) 
      frequent and spontaneous occurrences of large (40 beats per minute), brief rise 
      and fall in heart rate giving a striking "wave-like" appearance to the tracing. 
      These changes were more intense in the IDDM with moderate to severe, as compared 
      to mild withdrawal. Treatment of the infant's withdrawal with drugs resulted in a 
      clinical improvement, but the abnormal heart rate tracings persisted. Serum 
      creatine phosphokinase (CPK) was also elevated (greater than 450 IU/l) in the 
      IDDM (mean +/- SE = 984 +/- 299 IU/l) and 89% of the total CPK was the MM 
      fraction. These infants exhibited tremors and hypertonicity.
FAU - Ostrea, E M Jr
AU  - Ostrea EM Jr
AD  - Department of Pediatrics, Hutzel Hospital, Detroit, MI.
FAU - Kresbach, P
AU  - Kresbach P
FAU - Knapp, D K
AU  - Knapp DK
FAU - Simkowski, K
AU  - Simkowski K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 0 (Isoenzymes)
RN  - EC 2.7.3.2 (Creatine Kinase)
RN  - UC6VBE7V1Z (Methadone)
SB  - IM
MH  - Creatine Kinase/*blood
MH  - Female
MH  - Heart Rate/*drug effects
MH  - Humans
MH  - Infant, Newborn
MH  - Isoenzymes
MH  - Methadone/adverse effects
MH  - Neonatal Abstinence Syndrome/blood/*physiopathology
MH  - Pregnancy
MH  - Respiration/drug effects
EDAT- 1987/07/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1987/07/01 00:00
PHST- 1987/07/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1987/07/01 00:00 [entrez]
AID - 10.1016/0892-0362(87)90020-1 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 1987 Jul-Aug;9(4):305-9. doi: 10.1016/0892-0362(87)90020-1.