PMID- 36834166
OWN - NLM
STAT- MEDLINE
DCOM- 20230228
LR  - 20231117
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 20
IP  - 4
DP  - 2023 Feb 16
TI  - The Role of Preoperative Chronic Statin Therapy in Heart Transplant Receipts-A 
      Retrospective Single-Center Cohort Study.
LID - 10.3390/ijerph20043471 [doi]
LID - 3471
AB  - BACKGROUND: Statin therapy has been proven to reduce the risk of cardiovascular 
      events. The objective of our retrospective study was to investigate the 
      relationship between preoperative chronic administration of statins to 
      postoperative 2-month heart transplantation complications. METHODS: A total 
      number of 38 heart transplantation recipients from the Cardiovascular and 
      Transplant Emergency Institute of Targu Mures between May 2014 and January 2021 
      were included in our study. RESULTS: In logistic regression, we found a 
      statistical significance between statin treatment and the presence of 
      postoperative complications of any cause (OR: 0.06, 95% CI: 0.008-0.56; p = 
      0.0128), simultaneously presenting an elevated risk for early-postoperative acute 
      kidney injury (AKI). From the statin group, atorvastatin therapy had a higher 
      risk of type 2 diabetes mellitus (T2DM) development (OR: 29.73, 95% CI: 
      1.19-741.76; p = 0.0387) and AKI (OR: 29.73, 95% CI: 1.19-741.76; p = 0.0387). 
      C-reactive protein (CRP), total cholesterol (TC), and low-density lipoprotein 
      cholesterol (LDL-c) represented risk factors, atorvastatin administration being 
      independently associated with lower CRP values. CONCLUSIONS: Chronic previous 
      administration of statins represented a protective factor to the development of 
      2-month postoperative complications of any cause in heart transplant receipts.
FAU - Baba, Dragos-Florin
AU  - Baba DF
AUID- ORCID: 0000-0002-4004-9648
AD  - Emergency Institute for Cardiovascular Diseases and Transplantation, 540142 Targu 
      Mures, Romania.
AD  - Department of Cell and Molecular Biology, George Emil Palade University of 
      Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, 
      Romania.
FAU - Suciu, Horatiu
AU  - Suciu H
AD  - Emergency Institute for Cardiovascular Diseases and Transplantation, 540142 Targu 
      Mures, Romania.
AD  - Department of Surgery, George Emil Palade University of Medicine, Pharmacy, 
      Science and Technology of Targu Mures, 540142 Targu Mures, Romania.
FAU - Avram, Calin
AU  - Avram C
AUID- ORCID: 0000-0003-1488-3329
AD  - Department of Medical Informatics and Biostatistics, George Emil Palade 
      University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 
      Targu Mures, Romania.
FAU - Danilesco, Alina
AU  - Danilesco A
AD  - Department of Cell and Molecular Biology, George Emil Palade University of 
      Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, 
      Romania.
FAU - Moldovan, Diana Andreea
AU  - Moldovan DA
AD  - Emergency Institute for Cardiovascular Diseases and Transplantation, 540142 Targu 
      Mures, Romania.
FAU - Rauta, Radu Catalin
AU  - Rauta RC
AD  - Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science 
      and Technology of Targu Mures, 540142 Targu Mures, Romania.
FAU - Huma, Laurentiu
AU  - Huma L
AUID- ORCID: 0000-0002-9413-7803
AD  - Emergency Institute for Cardiovascular Diseases and Transplantation, 540142 Targu 
      Mures, Romania.
AD  - Department of Cell and Molecular Biology, George Emil Palade University of 
      Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, 
      Romania.
FAU - Sin, Ileana Anca
AU  - Sin IA
AD  - Department of Cell and Molecular Biology, George Emil Palade University of 
      Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, 
      Romania.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230216
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - A0JWA85V8F (Atorvastatin)
RN  - 0 (Cholesterol, LDL)
SB  - IM
MH  - Humans
MH  - *Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects
MH  - Atorvastatin
MH  - Retrospective Studies
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Cohort Studies
MH  - *Heart Transplantation/adverse effects
MH  - Cholesterol, LDL
MH  - *Acute Kidney Injury/etiology
MH  - Postoperative Complications
PMC - PMC9959876
OTO - NOTNLM
OT  - C-reactive protein
OT  - atorvastatin
OT  - complications
OT  - heart transplant
OT  - statin
COIS- The authors declare no conflict of interest.
EDAT- 2023/02/26 06:00
MHDA- 2023/03/03 06:00
PMCR- 2023/02/16
CRDT- 2023/02/25 02:30
PHST- 2023/02/01 00:00 [received]
PHST- 2023/02/14 00:00 [revised]
PHST- 2023/02/15 00:00 [accepted]
PHST- 2023/02/25 02:30 [entrez]
PHST- 2023/02/26 06:00 [pubmed]
PHST- 2023/03/03 06:00 [medline]
PHST- 2023/02/16 00:00 [pmc-release]
AID - ijerph20043471 [pii]
AID - ijerph-20-03471 [pii]
AID - 10.3390/ijerph20043471 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2023 Feb 16;20(4):3471. doi: 
      10.3390/ijerph20043471.