PMID- 36835899
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230301
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 12
IP  - 4
DP  - 2023 Feb 8
TI  - Big Endothelin-1 as a Predictor of Reverse Remodeling and Prognosis in Dilated 
      Cardiomyopathy.
LID - 10.3390/jcm12041363 [doi]
LID - 1363
AB  - This study aimed to investigate the predictive value of Big endothelin-1(ET-1) 
      for left ventricular reverse remodeling (LVRR) and prognosis in patients with 
      dilated cardiomyopathy (DCM). Patients with DCM and a left ventricular ejection 
      fraction (LVEF) </= 50% from 2008 to 2017 were included. LVRR was defined as the 
      LVEF increased by at least 10% or follow-up LVEF increased to at least 50% with a 
      minimum improvement of 5%; meanwhile, the index of left ventricular end-diastolic 
      diameter (LVEDDi) decreased by at least 10% or LVEDDi decreased to </=33 mm/m(2). 
      The composite outcome for prognostic analysis consisted of death and heart 
      transplantations. Of the 375 patients included (median age 47 years, 21.1% 
      female), 135 patients (36%) had LVRR after a median of 14 months of treatment. An 
      independent association was found between Big ET-1 at baseline and LVRR in the 
      multivariate model (OR 0.70, 95% CI 0.55-0.89, p = 0.003, per log increase). Big 
      ET-1, body mass index, systolic blood pressure, diagnosis of type 2 diabetes 
      mellitus (T2DM) and treatment with ACEI/ARB were significant predictors for LVRR 
      after stepwise selection. Adding Big ET-1 to the model improved the 
      discrimination (∆AUC = 0.037, p = 0.042 and reclassification (IDI, 3.29%; p = 
      0.002; NRI, 35%; p = 0.002) for identifying patients with LVRR. During a median 
      follow-up of 39 (27-68) months, Big ET-1 was also independently associated with 
      the composite outcome of death and heart transplantations (HR 1.45, 95% CI 
      1.13-1.85, p = 0.003, per log increase). In conclusion, Big ET-1 was an 
      independent predictor for LVRR and had prognostic implications, which might help 
      to improve the risk stratification of patients with DCM.
FAU - Feng, Jiayu
AU  - Feng J
AUID- ORCID: 0000-0001-6339-7779
AD  - State Key Laboratory of Cardiovascular Disease, Heart Failure Center, National 
      Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, Beijing 100037, China.
FAU - Liang, Lin
AU  - Liang L
AD  - State Key Laboratory of Cardiovascular Disease, Heart Failure Center, National 
      Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, Beijing 100037, China.
FAU - Chen, Yuyi
AU  - Chen Y
AD  - State Key Laboratory of Cardiovascular Disease, Heart Failure Center, National 
      Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, Beijing 100037, China.
FAU - Tian, Pengchao
AU  - Tian P
AD  - State Key Laboratory of Cardiovascular Disease, Heart Failure Center, National 
      Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, Beijing 100037, China.
FAU - Zhao, Xuemei
AU  - Zhao X
AD  - State Key Laboratory of Cardiovascular Disease, Heart Failure Center, National 
      Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, Beijing 100037, China.
FAU - Huang, Boping
AU  - Huang B
AD  - State Key Laboratory of Cardiovascular Disease, Heart Failure Center, National 
      Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, Beijing 100037, China.
FAU - Wu, Yihang
AU  - Wu Y
AD  - State Key Laboratory of Cardiovascular Disease, Heart Failure Center, National 
      Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, Beijing 100037, China.
FAU - Wang, Jing
AU  - Wang J
AD  - State Key Laboratory of Cardiovascular Disease, Heart Failure Center, National 
      Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, Beijing 100037, China.
FAU - Guan, Jingyuan
AU  - Guan J
AD  - State Key Laboratory of Cardiovascular Disease, Heart Failure Center, National 
      Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, Beijing 100037, China.
FAU - Huang, Liyan
AU  - Huang L
AD  - State Key Laboratory of Cardiovascular Disease, Heart Failure Center, National 
      Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, Beijing 100037, China.
FAU - Li, Xinqing
AU  - Li X
AD  - State Key Laboratory of Cardiovascular Disease, Heart Failure Center, National 
      Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, Beijing 100037, China.
FAU - Zhang, Yuhui
AU  - Zhang Y
AD  - State Key Laboratory of Cardiovascular Disease, Heart Failure Center, National 
      Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, Beijing 100037, China.
FAU - Zhang, Jian
AU  - Zhang J
AD  - State Key Laboratory of Cardiovascular Disease, Heart Failure Center, National 
      Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, Beijing 100037, China.
AD  - Key Laboratory of Clinical Research for Cardiovascular Medications, National 
      Health Committee, Beijing 100037, China.
LA  - eng
GR  - 81873472/National Nature Science Foundation of China/
PT  - Journal Article
DEP - 20230208
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC9967115
OTO - NOTNLM
OT  - biomarker
OT  - dilated cardiomyopathy
OT  - predictive model
OT  - reverse remodeling
COIS- The authors declare no conflict of interest.
EDAT- 2023/02/26 06:00
MHDA- 2023/02/26 06:01
PMCR- 2023/02/08
CRDT- 2023/02/25 03:02
PHST- 2023/01/06 00:00 [received]
PHST- 2023/01/24 00:00 [revised]
PHST- 2023/02/07 00:00 [accepted]
PHST- 2023/02/25 03:02 [entrez]
PHST- 2023/02/26 06:00 [pubmed]
PHST- 2023/02/26 06:01 [medline]
PHST- 2023/02/08 00:00 [pmc-release]
AID - jcm12041363 [pii]
AID - jcm-12-01363 [pii]
AID - 10.3390/jcm12041363 [doi]
PST - epublish
SO  - J Clin Med. 2023 Feb 8;12(4):1363. doi: 10.3390/jcm12041363.