PMID- 36836074 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230301 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 12 IP - 4 DP - 2023 Feb 15 TI - Establishing the Minimum Clinically Significant Difference (MCID) and the Patient Acceptable Symptom Score (PASS) for the Hospital Anxiety and Depression Scale (HADS) in Patients with Rotator Cuff Disease and Shoulder Prosthesis. LID - 10.3390/jcm12041540 [doi] LID - 1540 AB - Insufficiently treated shoulder pain may cause mental disturbances, including depression and anxiety. The Hospital Anxiety and Depression Scale (HADS) is a patient-reported outcome measure (PROM) that aims to identify depression and anxiety in patients in nonpsychiatric wards. The aim of this study was to identify the minimum clinically important difference (MCID) and patient acceptable symptom state (PASS) scores for the HADS in a cohort of individuals with rotator cuff disease. Using the HADS, participants' degrees of anxiety and depression were assessed at inception and at their final assessment 6 months after surgery. To calculate the MCID and the PASS, distribution and anchor approaches were employed. The MCID from inception to final assessment was 5.7 on the HADS, 3.8 on the HADS-A, and 3.3 on the HADS-D. A 5.7 amelioration on the HADS score, 3.8 on the HADS-A, and 3.3 on the HADS-D, from inception to final assessment, meant that patients had reached a clinically meaningful improvement in their symptom state. The PASS was 7 on the HADS, 3.5 on the HADS-A, and 3.5 on the HADS-D; therefore, for the majority of patients, a score of at least 7 on the HADS, 3.5 on the HADS-A, and 3.5 on the HADS-D at final evaluation was considered a satisfactory symptom state. FAU - Longo, Umile Giuseppe AU - Longo UG AUID- ORCID: 0000-0003-4063-9821 AD - Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Roma, Italy. AD - Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery, Universita Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Roma, Italy. FAU - Papalia, Rocco AU - Papalia R AD - Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Roma, Italy. AD - Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery, Universita Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Roma, Italy. FAU - De Salvatore, Sergio AU - De Salvatore S AUID- ORCID: 0000-0002-9111-3638 AD - Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Roma, Italy. AD - Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery, Universita Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Roma, Italy. FAU - Marinozzi, Andrea AU - Marinozzi A AD - Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Roma, Italy. AD - Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery, Universita Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Roma, Italy. FAU - Piergentili, Ilaria AU - Piergentili I AD - Laboratory of Measurement and Biomedical Instrumentation, Campus Bio-Medico University, Via Alvaro del Portillo 200, 00128 Rome, Italy. FAU - Lalli, Alberto AU - Lalli A AUID- ORCID: 0000-0001-8043-1705 AD - Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Roma, Italy. AD - Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery, Universita Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Roma, Italy. FAU - Bandini, Benedetta AU - Bandini B AUID- ORCID: 0000-0001-5909-3887 AD - Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Roma, Italy. AD - Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery, Universita Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Roma, Italy. FAU - Franceschetti, Edoardo AU - Franceschetti E AD - Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Roma, Italy. AD - Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery, Universita Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Roma, Italy. FAU - Denaro, Vincenzo AU - Denaro V AD - Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo 200, 00128 Roma, Italy. AD - Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery, Universita Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Roma, Italy. LA - eng PT - Journal Article DEP - 20230215 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC9967741 OTO - NOTNLM OT - HADS OT - MCID OT - PASS OT - PROM OT - shoulder arthroplasty COIS- U.G.L. is a member of the J. Clin. Med. Editorial Board. The remaining authors declare that they have no conflict of interest. EDAT- 2023/02/26 06:00 MHDA- 2023/02/26 06:01 PMCR- 2023/02/15 CRDT- 2023/02/25 03:06 PHST- 2023/01/02 00:00 [received] PHST- 2023/02/10 00:00 [revised] PHST- 2023/02/13 00:00 [accepted] PHST- 2023/02/25 03:06 [entrez] PHST- 2023/02/26 06:00 [pubmed] PHST- 2023/02/26 06:01 [medline] PHST- 2023/02/15 00:00 [pmc-release] AID - jcm12041540 [pii] AID - jcm-12-01540 [pii] AID - 10.3390/jcm12041540 [doi] PST - epublish SO - J Clin Med. 2023 Feb 15;12(4):1540. doi: 10.3390/jcm12041540.