PMID- 36836190
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230301
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 12
IP  - 4
DP  - 2023 Feb 19
TI  - Factors Related to Plasma Homocysteine Concentration in Young Adults: A 
      Retrospective Study Based on Checkup Populations.
LID - 10.3390/jcm12041656 [doi]
LID - 1656
AB  - The distribution profile of plasma homocysteine (Hcy) in young adults and its 
      related factors are not well understood. We performed a generalized estimating 
      equations (GEE) analysis for plasma-Hcy-correlated factors in 2436 young adults, 
      aged 20-39 years, from a health checkup population. We observed that the mean Hcy 
      concentration in males (16.7 +/- 10.3 mumol/L) was significantly higher than that in 
      females (10.3 +/- 4.0 mumol/L), and hyperhomocysteinemia (HHcy) prevalence in males 
      was 5.37 times than that in females (33.3% vs. 6.2%). A GEE analysis stratified 
      by sex indicated that age (B = -0.398, p < 0.001) and LDL-C (B = -1.602, p = 
      0.043) were negatively correlated, while BMI (B = 0.400, p = 0.042) was 
      positively correlated, with the Hcy level in young males. ALT (B = -0.021, p = 
      0.033), LDL-C (B = -1.198, p < 0.001) and Glu (B = -0.446, p = 0.006) were 
      negatively correlated, while AST (B = 0.022, p = 0.048), CREA (B = 0.035, p < 
      0.001), UA (B = 0.004, p = 0.003) and TG (B = 1.042, p < 0.001) were positively 
      correlated, with the Hcy level in young females. These results suggest that young 
      males have a significantly higher plasma Hcy level and HHcy prevalence than young 
      females; therefore, more attention should be paid to the reason for and effect of 
      the higher HHcy prevalence in young males.
FAU - Li, Zhihua
AU  - Li Z
AD  - Information Center, Xuanwu Hospital, Capital Medical University, No. 45 Changchun 
      Street, Xicheng District, Beijing 100053, China.
FAU - Zhao, Jing
AU  - Zhao J
AD  - Health Management Department, Xuanwu Hospital, Capital Medical University, No. 45 
      Changchun Street, Xicheng District, Beijing 100053, China.
FAU - Hou, Chengbei
AU  - Hou C
AD  - Department of Evidence-Based Medicine, Xuanwu Hospital, Capital Medical 
      University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China.
FAU - Sun, Fei
AU  - Sun F
AD  - Beijing Geriatric Healthcare Center, Xuanwu Hospital, Capital Medical University, 
      No. 45 Changchun Street, Xicheng District, Beijing 100053, China.
FAU - Dong, Jing
AU  - Dong J
AD  - Health Management Department, Xuanwu Hospital, Capital Medical University, No. 45 
      Changchun Street, Xicheng District, Beijing 100053, China.
FAU - Guo, Yansu
AU  - Guo Y
AD  - Department of Evidence-Based Medicine, Xuanwu Hospital, Capital Medical 
      University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China.
AD  - Beijing Geriatric Healthcare Center, Xuanwu Hospital, Capital Medical University, 
      No. 45 Changchun Street, Xicheng District, Beijing 100053, China.
FAU - Chu, Xi
AU  - Chu X
AD  - Health Management Department, Xuanwu Hospital, Capital Medical University, No. 45 
      Changchun Street, Xicheng District, Beijing 100053, China.
LA  - eng
GR  - no/Beijing Municipal Key Laboratory of Clinical Epidemiology, China/
GR  - 81971200/National Natural Science Foundation of China/
GR  - 7222082/Beijing Municipal Natural Science Foundation, China/
PT  - Journal Article
DEP - 20230219
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC9967549
OTO - NOTNLM
OT  - BMI
OT  - correlation analysis
OT  - homocysteine
OT  - hyperhomocysteinemia
OT  - young adults
COIS- The authors declare that they have no competing interests.
EDAT- 2023/02/26 06:00
MHDA- 2023/02/26 06:01
PMCR- 2023/02/19
CRDT- 2023/02/25 03:08
PHST- 2022/12/01 00:00 [received]
PHST- 2023/02/10 00:00 [revised]
PHST- 2023/02/15 00:00 [accepted]
PHST- 2023/02/25 03:08 [entrez]
PHST- 2023/02/26 06:00 [pubmed]
PHST- 2023/02/26 06:01 [medline]
PHST- 2023/02/19 00:00 [pmc-release]
AID - jcm12041656 [pii]
AID - jcm-12-01656 [pii]
AID - 10.3390/jcm12041656 [doi]
PST - epublish
SO  - J Clin Med. 2023 Feb 19;12(4):1656. doi: 10.3390/jcm12041656.