PMID- 36836488
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230301
IS  - 2075-4426 (Print)
IS  - 2075-4426 (Electronic)
IS  - 2075-4426 (Linking)
VI  - 13
IP  - 2
DP  - 2023 Jan 30
TI  - Analysis of Retinal Microstructure in Eyes with Dissociated Optic Nerve Fiber 
      Layer (DONFL) Appearance following Idiopathic Macular Hole Surgery: An Optical 
      Coherence Tomography Study.
LID - 10.3390/jpm13020255 [doi]
LID - 255
AB  - (1) Purpose: This study aimed to evaluate morphological changes of the retina in 
      eyes with dissociated optic nerve fiber layer (DONFL) appearance following 
      internal limiting membrane (ILM) peeling for full-thickness idiopathic macular 
      hole (IMH) on spectral-domain optical coherence tomography (SD-OCT). (2) Methods: 
      We retrospectively analyzed 39 eyes of 39 patients with type 1 macular hole 
      closure after a vitrectomy with ILM peeling procedure at a six-month minimum 
      postoperative follow-up. The retinal thickness maps and cross-sectional OCT 
      images were obtained from a clinical OCT device. The cross-sectional area of the 
      retinal nerve fiber layer (RNFL) on cross-sectional OCT images was manually 
      measured by ImageJ software. (3) Results: The inner retinal layers (IRLs) 
      thickness thinned down much more in the temporal quadrant than in nasal quadrants 
      at 2 and 6 months postoperatively (p < 0.001). However, the cross-sectional area 
      of the RNFL did not change significantly at 2 and 6 months postoperatively (p > 
      0.05) when compared to preoperative data. In addition, the thinning of the IRL 
      did not correlate with the best-corrected visual acuity (BCVA) at 6 months 
      postoperatively. (4) Conclusions: The thickness of the IRL decreased in eyes with 
      a DONFL appearance after ILM peeling for IMH. The thickness of the IRL decreased 
      more in the temporal retina than in the nasal retina, but the change did not 
      affect BCVA during the 6 months after surgery.
FAU - He, Shucheng
AU  - He S
AD  - National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou 
      Medical University, Wenzhou 325027, China.
FAU - Ye, Xin
AU  - Ye X
AD  - National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou 
      Medical University, Wenzhou 325027, China.
FAU - Qiu, Wangli
AU  - Qiu W
AD  - National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou 
      Medical University, Wenzhou 325027, China.
FAU - Yang, Shangchao
AU  - Yang S
AD  - National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou 
      Medical University, Wenzhou 325027, China.
FAU - Zhong, Xiaxing
AU  - Zhong X
AD  - National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou 
      Medical University, Wenzhou 325027, China.
FAU - Chen, Yiqi
AU  - Chen Y
AD  - Department of Ophthalmology, Zhejiang Provincial People's Hospital, Hangzhou 
      310014, China.
FAU - He, Rui
AU  - He R
AD  - Computer Science & Software School, Hangzhou Dianzi University, Hangzhou 310018, 
      China.
FAU - Shen, Lijun
AU  - Shen L
AD  - National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou 
      Medical University, Wenzhou 325027, China.
AD  - Department of Ophthalmology, Zhejiang Provincial People's Hospital, Hangzhou 
      310014, China.
LA  - eng
PT  - Journal Article
DEP - 20230130
PL  - Switzerland
TA  - J Pers Med
JT  - Journal of personalized medicine
JID - 101602269
PMC - PMC9963747
OTO - NOTNLM
OT  - dissociated optic nerve fiber layer
OT  - idiopathic full-thickness macular hole
OT  - internal limiting membrane
OT  - optical coherence tomography
OT  - retinal dimples
COIS- The authors declare no conflict of interest.
EDAT- 2023/02/26 06:00
MHDA- 2023/02/26 06:01
PMCR- 2023/01/30
CRDT- 2023/02/25 03:14
PHST- 2022/12/27 00:00 [received]
PHST- 2023/01/21 00:00 [revised]
PHST- 2023/01/28 00:00 [accepted]
PHST- 2023/02/25 03:14 [entrez]
PHST- 2023/02/26 06:00 [pubmed]
PHST- 2023/02/26 06:01 [medline]
PHST- 2023/01/30 00:00 [pmc-release]
AID - jpm13020255 [pii]
AID - jpm-13-00255 [pii]
AID - 10.3390/jpm13020255 [doi]
PST - epublish
SO  - J Pers Med. 2023 Jan 30;13(2):255. doi: 10.3390/jpm13020255.