PMID- 36836550
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230228
IS  - 2075-4426 (Print)
IS  - 2075-4426 (Electronic)
IS  - 2075-4426 (Linking)
VI  - 13
IP  - 2
DP  - 2023 Feb 11
TI  - Sex-Related Differences and Factors Associated with Peri-Procedural and 1 Year 
      Mortality in Chronic Limb-Threatening Ischemia Patients from the CLIMATE Italian 
      Registry.
LID - 10.3390/jpm13020316 [doi]
LID - 316
AB  - BACKGROUND: Identifying sex-related differences/variables associated with 30 
      day/1 year mortality in patients with chronic limb-threatening ischemia (CLTI). 
      METHODS: Multicenter/retrospective/observational study. A database was sent to 
      all the Italian vascular surgeries to collect all the patients operated on for 
      CLTI in 2019. Acute lower-limb ischemia and neuropathic-diabetic foot are not 
      included. FOLLOW-UP: One year. Data on demographics/comorbidities, 
      treatments/outcomes, and 30 day/1 year mortality were investigated. RESULTS: 
      Information on 2399 cases (69.8% men) from 36/143 (25.2%) centers. Median (IQR) 
      age: 73 (66-80) and 79 (71-85) years for men/women, respectively (p < 0.0001). 
      Women were more likely to be over 75 (63.2% vs. 40.1%, p = 0.0001). More men 
      smokers (73.7% vs. 42.2%, p < 0.0001), are on hemodialysis (10.1% vs. 6.7%, p = 
      0.006), affected by diabetes (61.9% vs. 52.8%, p < 0.0001), dyslipidemia (69.3% 
      vs. 61.3%, p < 0.0001), hypertension (91.8% vs. 88.5%, p = 0.011), coronaropathy 
      (43.9% vs. 29.4%, p < 0.0001), bronchopneumopathy (37.1% vs. 25.6%, p < 0.0001), 
      underwent more open/hybrid surgeries (37.9% vs. 28.8%, p < 0.0001), and minor 
      amputations (22% vs. 13.7%, p < 0.0001). More women underwent endovascular 
      revascularizations (61.6% vs. 55.2%, p = 0.004), major amputations (9.6% vs. 
      6.9%, p = 0.024), and obtained limb-salvage if with limited gangrene (50.8% vs. 
      44.9%, p = 0.017). Age > 75 (HR = 3.63, p = 0.003) is associated with 30 day 
      mortality. Age > 75 (HR = 2.14, p < 0.0001), nephropathy (HR = 1.54, p < 0.0001), 
      coronaropathy (HR = 1.26, p = 0.036), and infection/necrosis of the foot (dry, HR 
      = 1.42, p = 0.040; wet, HR = 2.04, p < 0.0001) are associated with 1 year 
      mortality. No sex-linked difference in mortality statistics. CONCLUSION: Women 
      exhibit fewer comorbidities but are struck by CLTI when over 75, a factor 
      associated with short- and mid-term mortality, explaining why mortality does not 
      statistically differ between the sexes.
FAU - Martelli, Eugenio
AU  - Martelli E
AUID- ORCID: 0000-0001-5764-0082
AD  - Department of General and Specialist Surgery Paride Stefanini, Faculty of 
      Pharmacy and Medicine, Sapienza University of Rome, 155 viale del Policlinico, 
      00161 Rome, Italy.
AD  - Medicine and Surgery School of Medicine, Saint Camillus International University 
      of Health Sciences, 8 via di Sant'Alessandro, 00131 Rome, Italy.
AD  - Division of Vascular Surgery, Department of Cardiovascular Sciences, S. Anna and 
      S. Sebastiano Hospital, via F. Palasciano, 81100 Caserta, Italy.
FAU - Zamboni, Matilde
AU  - Zamboni M
AUID- ORCID: 0000-0002-6750-919X
AD  - Division of Vascular Surgery, Saint Martin Hospital, 22 viale Europa, 32100 
      Belluno, Italy.
FAU - Sotgiu, Giovanni
AU  - Sotgiu G
AUID- ORCID: 0000-0002-1600-4474
AD  - Clinical Epidemiology and Medical Statistics Unit, Department of Medicine, 
      Surgery and Pharmacy, University of Sassari, viale San Pietro, 07100 Sassari, 
      Italy.
FAU - Saderi, Laura
AU  - Saderi L
AUID- ORCID: 0000-0002-5131-9367
AD  - Clinical Epidemiology and Medical Statistics Unit, Department of Medicine, 
      Surgery and Pharmacy, University of Sassari, viale San Pietro, 07100 Sassari, 
      Italy.
FAU - Federici, Massimo
AU  - Federici M
AD  - Department of Systems Medicine, University of Rome Tor Vergata, 1 viale 
      Montpellier, 00133 Rome, Italy.
FAU - Sangiorgi, Giuseppe M
AU  - Sangiorgi GM
AUID- ORCID: 0000-0001-5862-1967
AD  - Department of Biomedicine and Prevention, University of Rome Tor Vergata, 1 viale 
      Montpellier, 00133 Rome, Italy.
FAU - Puci, Mariangela V
AU  - Puci MV
AUID- ORCID: 0000-0001-5656-6845
AD  - Clinical Epidemiology and Medical Statistics Unit, Department of Medicine, 
      Surgery and Pharmacy, University of Sassari, viale San Pietro, 07100 Sassari, 
      Italy.
FAU - Martelli, Allegra R
AU  - Martelli AR
AD  - Medicine and Surgery School of Medicine, Campus Bio-Medico University of Rome, 21 
      via A. del Portillo, 00128 Rome, Italy.
FAU - Messina, Teresa
AU  - Messina T
AD  - Division of Anesthesia and Intensive Care of Organ Transplants, Umberto I 
      Polyclinic University Hospital, 155 viale del Policlinico, 00161 Rome, Italy.
FAU - Frigatti, Paolo
AU  - Frigatti P
AUID- ORCID: 0000-0002-4248-6673
AD  - Divisions of Vascular Surgery, S. Maria Misericordia University Hospital, 15 
      Piazzale Santa Maria della Misericordia, 33100 Udine, Italy.
FAU - Borrelli, Maria Pia
AU  - Borrelli MP
AD  - Divisions of Vascular Surgery, S. Maria Misericordia University Hospital, 15 
      Piazzale Santa Maria della Misericordia, 33100 Udine, Italy.
FAU - Ruotolo, Carlo
AU  - Ruotolo C
AD  - Divisions of Vascular Surgery, Cardarelli Hospital, 9 Via A. Cardarelli, 80131 
      Naples, Italy.
FAU - Ficarelli, Ilaria
AU  - Ficarelli I
AD  - Divisions of Vascular Surgery, Cardarelli Hospital, 9 Via A. Cardarelli, 80131 
      Naples, Italy.
FAU - Rubino, Paolo
AU  - Rubino P
AD  - Divisions of Vascular Surgery, Pugliese Ciaccio Hospital, 83 viale Pio X, 88100 
      Catanzaro, Italy.
FAU - Pezzo, Francesco
AU  - Pezzo F
AD  - Divisions of Vascular Surgery, Pugliese Ciaccio Hospital, 83 viale Pio X, 88100 
      Catanzaro, Italy.
FAU - Carbonari, Luciano
AU  - Carbonari L
AD  - Divisions of Vascular Surgery, Riuniti University Hospitals, 71 via Conca, 
      Torrette (AN), 60126 Ancona, Italy.
FAU - Angelini, Andrea
AU  - Angelini A
AD  - Divisions of Vascular Surgery, Riuniti University Hospitals, 71 via Conca, 
      Torrette (AN), 60126 Ancona, Italy.
FAU - Galeazzi, Edoardo
AU  - Galeazzi E
AD  - Divisions of Vascular Surgery, Treviso Hospital, 1 piazzale del'Ospedale, 31100 
      Treviso, Italy.
FAU - Di Pinto, Luca Calia
AU  - Di Pinto LC
AD  - Divisions of Vascular Surgery, Treviso Hospital, 1 piazzale del'Ospedale, 31100 
      Treviso, Italy.
FAU - Fiore, Franco M
AU  - Fiore FM
AD  - Divisions of Vascular Surgery, SS. Annunziata Hospital, 31 via dei Vestini, 66100 
      Chieti, Italy.
FAU - Palmieri, Armando
AU  - Palmieri A
AD  - Divisions of Vascular Surgery, SS. Annunziata Hospital, 31 via dei Vestini, 66100 
      Chieti, Italy.
FAU - Ventoruzzo, Giorgio
AU  - Ventoruzzo G
AD  - Divisions of Vascular Surgery, San Donato Hospital, 20 via Pietro Nenni, 52100 
      Arezzo, Italy.
FAU - Mazzitelli, Giulia
AU  - Mazzitelli G
AD  - Divisions of Vascular Surgery, San Donato Hospital, 20 via Pietro Nenni, 52100 
      Arezzo, Italy.
FAU - Ragni, Franco
AU  - Ragni F
AD  - Divisions of Vascular Surgery, San Matteo Polyclinic, 19 viale Camillo Golgi, 
      27100 Pavia, Italy.
FAU - Bozzani, Antonio
AU  - Bozzani A
AUID- ORCID: 0000-0003-3274-6248
AD  - Divisions of Vascular Surgery, San Matteo Polyclinic, 19 viale Camillo Golgi, 
      27100 Pavia, Italy.
FAU - Forliti, Enzo
AU  - Forliti E
AD  - Divisions of Vascular Surgery, Infermi Hospital, Via dei Ponderanesi 2, 13875 
      Ponderano, Italy.
FAU - Castagno, Claudio
AU  - Castagno C
AD  - Divisions of Vascular Surgery, Infermi Hospital, Via dei Ponderanesi 2, 13875 
      Ponderano, Italy.
FAU - Volpe, Pietro
AU  - Volpe P
AD  - Divisions of Vascular Surgery, Bianchi-Melacrino-Morelli Hospital, 21 via G. 
      Melacrino, 89124 Reggio di Calabria, Italy.
FAU - Massara, Mafalda
AU  - Massara M
AD  - Divisions of Vascular Surgery, Bianchi-Melacrino-Morelli Hospital, 21 via G. 
      Melacrino, 89124 Reggio di Calabria, Italy.
FAU - Moniaci, Diego
AU  - Moniaci D
AUID- ORCID: 0000-0003-4324-6126
AD  - Divisions of Vascular Surgery, San Giovanni Bosco Hospital, 3 piazza del Donatore 
      di Sangue, 10154 Turin, Italy.
FAU - Pagliasso, Elisa
AU  - Pagliasso E
AD  - Divisions of Vascular Surgery, San Giovanni Bosco Hospital, 3 piazza del Donatore 
      di Sangue, 10154 Turin, Italy.
FAU - Peretti, Tania
AU  - Peretti T
AD  - Divisions of Vascular Surgery, San Giovanni Bosco Hospital, 3 piazza del Donatore 
      di Sangue, 10154 Turin, Italy.
FAU - Ferrari, Mauro
AU  - Ferrari M
AD  - Divisions of Vascular Surgery, Department of Translational Research and New 
      Technologies in Medicine and Surgery, University of Pisa, 2 via Paradisa, 56124 
      Pisa, Italy.
FAU - Troisi, Nicola
AU  - Troisi N
AUID- ORCID: 0000-0002-8779-9120
AD  - Divisions of Vascular Surgery, Department of Translational Research and New 
      Technologies in Medicine and Surgery, University of Pisa, 2 via Paradisa, 56124 
      Pisa, Italy.
FAU - Modugno, Piero
AU  - Modugno P
AD  - Divisions of Vascular Surgery, Gemelli Molise Hospital, 1 largo A. Gemelli, 86100 
      Campobasso, Italy.
FAU - Maiorano, Maurizio
AU  - Maiorano M
AD  - Divisions of Vascular Surgery, Gemelli Molise Hospital, 1 largo A. Gemelli, 86100 
      Campobasso, Italy.
FAU - Bracale, Umberto M
AU  - Bracale UM
AUID- ORCID: 0000-0001-9507-9791
AD  - Divisions of Vascular Surgery, Federico II Polyclinic, Department of Public 
      Health and Residency Program in Vascular Surgery, University of Naples Federico 
      II, 5 via S. Pansini, 80131 Naples, Italy.
FAU - Panagrosso, Marco
AU  - Panagrosso M
AD  - Divisions of Vascular Surgery, Federico II Polyclinic, Department of Public 
      Health and Residency Program in Vascular Surgery, University of Naples Federico 
      II, 5 via S. Pansini, 80131 Naples, Italy.
FAU - Monaco, Mario
AU  - Monaco M
AD  - Divisions of Vascular Surgery, Pineta Grande Hospital, Km. 30 via Domitiana, 
      81030 Castelvolturno, Italy.
AD  - Divisions of Vascular Surgery, Sanatrix Clinic, 31 via S. Domenico, 80127 Naples, 
      Italy.
FAU - Giordano, Giovanni
AU  - Giordano G
AD  - Divisions of Vascular Surgery, Sanatrix Clinic, 31 via S. Domenico, 80127 Naples, 
      Italy.
FAU - Natalicchio, Giuseppe
AU  - Natalicchio G
AD  - Divisions of Vascular Surgery, Venere Hospital, 1 via Ospedale di Venere, 70131 
      Bari, Italy.
FAU - Biello, Antonella
AU  - Biello A
AD  - Divisions of Vascular Surgery, Venere Hospital, 1 via Ospedale di Venere, 70131 
      Bari, Italy.
FAU - Celoria, Giovanni M
AU  - Celoria GM
AD  - Divisions of Vascular Surgery, Sant'Andrea Hospital, 197 via Vittorio Veneto, 
      19121 La Spezia, Italy.
FAU - Amico, Alessio
AU  - Amico A
AD  - Divisions of Vascular Surgery, Sant'Andrea Hospital, 197 via Vittorio Veneto, 
      19121 La Spezia, Italy.
FAU - Di Bartolo, Mauro
AU  - Di Bartolo M
AUID- ORCID: 0000-0003-4510-3663
AD  - Divisions of Vascular Surgery, Sant'Andrea Hospital, 197 via Vittorio Veneto, 
      19121 La Spezia, Italy.
FAU - Martelli, Massimiliano
AU  - Martelli M
AD  - Divisions of Vascular Surgery, MultiMedica Hospital, 300 via Milenese, 20099 
      Sesto San Giovanni, Italy.
FAU - Munao, Roberta
AU  - Munao R
AD  - Divisions of Vascular Surgery, MultiMedica Hospital, 300 via Milenese, 20099 
      Sesto San Giovanni, Italy.
FAU - Razzano, Davide
AU  - Razzano D
AD  - Divisions of Vascular Surgery, San Pio Hospital, 1 via dell'angelo, 82100 
      Benevento, Italy.
FAU - Colacchio, Giovanni
AU  - Colacchio G
AUID- ORCID: 0000-0003-0216-9005
AD  - Divisions of Vascular Surgery, F.Miulli Hospital, Strada Prov. 127 
      Acquaviva-Santeramo Km. 4, 70021 Acquaviva delle Fonti, Italy.
FAU - Bussetti, Francesco
AU  - Bussetti F
AD  - Divisions of Vascular Surgery, F.Miulli Hospital, Strada Prov. 127 
      Acquaviva-Santeramo Km. 4, 70021 Acquaviva delle Fonti, Italy.
FAU - Lanza, Gaetano
AU  - Lanza G
AD  - Divisions of Vascular Surgery, Multimedica Hospital, 70 viale Piemonte, 21053 
      Castellanza, Italy.
FAU - Cardini, Antonio
AU  - Cardini A
AD  - Divisions of Vascular Surgery, Multimedica Hospital, 70 viale Piemonte, 21053 
      Castellanza, Italy.
FAU - Di Benedetto, Bartolomeo
AU  - Di Benedetto B
AD  - Divisions of Vascular Surgery, Monaldi Hospital, via L. Bianchi, 84100 Naples, 
      Italy.
FAU - De Laurentis, Mario
AU  - De Laurentis M
AD  - Divisions of Vascular Surgery, Monaldi Hospital, via L. Bianchi, 84100 Naples, 
      Italy.
FAU - Taurino, Maurizio
AU  - Taurino M
AUID- ORCID: 0000-0001-5853-9410
AD  - Divisions of Vascular Surgery, Department of Molecular and Clinical Medicine, 
      Sapienza University of Rome, Giorgio Nicola Papanicolau, 00189 Rome, Italy.
AD  - Divisions of Vascular Surgery, Sant'Andrea University Hospital, 1035/1039 via di 
      Grottarossa, 00189 Rome, Italy.
FAU - Sirignano, Pasqualino
AU  - Sirignano P
AUID- ORCID: 0000-0002-1312-1915
AD  - Department of General and Specialist Surgery Paride Stefanini, Faculty of 
      Pharmacy and Medicine, Sapienza University of Rome, 155 viale del Policlinico, 
      00161 Rome, Italy.
AD  - Divisions of Vascular Surgery, Sant'Andrea University Hospital, 1035/1039 via di 
      Grottarossa, 00189 Rome, Italy.
FAU - Cappiello, Pierluigi
AU  - Cappiello P
AD  - Divisions of Vascular Surgery, San Carlo Hospital, via Potito Petrone, 85100 
      Potenza, Italy.
FAU - Esposito, Andrea
AU  - Esposito A
AD  - Divisions of Vascular Surgery, San Carlo Hospital, via Potito Petrone, 85100 
      Potenza, Italy.
FAU - Trimarchi, Santi
AU  - Trimarchi S
AD  - Divisions of Vascular Surgery, Department of Clinical and Community Sciences, 
      University of Milan, 19 via della Commenda, 20122 Milan, Italy.
AD  - Divisions of Vascular Surgery, Maggiore Polyclinic Hospital Ca' Granda IRCCS and 
      Foundation, 35 via Francesco Sforza, 20122 Milan, Italy.
FAU - Romagnoli, Silvia
AU  - Romagnoli S
AD  - Divisions of Vascular Surgery, Maggiore Polyclinic Hospital Ca' Granda IRCCS and 
      Foundation, 35 via Francesco Sforza, 20122 Milan, Italy.
FAU - Padricelli, Andrea
AU  - Padricelli A
AD  - Division of Vascular Surgery, Department of Cardiovascular Sciences, S. Anna and 
      S. Sebastiano Hospital, via F. Palasciano, 81100 Caserta, Italy.
FAU - Giudice, Giorgio
AU  - Giudice G
AD  - Division of Vascular Surgery, Department of Cardiovascular Sciences, S. Anna and 
      S. Sebastiano Hospital, via F. Palasciano, 81100 Caserta, Italy.
FAU - Crinisio, Adolfo
AU  - Crinisio A
AD  - Divisions of Vascular Surgery, Salus Clinic, 4 via F. Confalonieri, 84091 
      Battipaglia, Italy.
FAU - Di Nardo, Giovanni
AU  - Di Nardo G
AD  - Divisions of Vascular Surgery, Salus Clinic, 4 via F. Confalonieri, 84091 
      Battipaglia, Italy.
FAU - Battaglia, Giuseppe
AU  - Battaglia G
AD  - Divisions of Vascular Surgery, San Marco Hospital, viale Carlo Azeglio Ciampi, 
      95121 Catania, Italy.
FAU - Tringale, Rosario
AU  - Tringale R
AD  - Divisions of Vascular Surgery, San Marco Hospital, viale Carlo Azeglio Ciampi, 
      95121 Catania, Italy.
FAU - De Vivo, Salvatore
AU  - De Vivo S
AD  - Divisions of Vascular Surgery, Pellegrini Hospital, 41 via Portamedina alla 
      Pignasecca, 80134 Naples, Italy.
FAU - Compagna, Rita
AU  - Compagna R
AD  - Divisions of Vascular Surgery, Pellegrini Hospital, 41 via Portamedina alla 
      Pignasecca, 80134 Naples, Italy.
FAU - Tolva, Valerio S
AU  - Tolva VS
AUID- ORCID: 0000-0002-4642-0727
AD  - Divisions of Vascular Surgery, Niguarda Hospital, Piazza dell'Ospedale Maggiore 
      3, 20161 Milan, Italy.
FAU - D'Alessio, Ilenia
AU  - D'Alessio I
AD  - Divisions of Vascular Surgery, Niguarda Hospital, Piazza dell'Ospedale Maggiore 
      3, 20161 Milan, Italy.
FAU - Curci, Ruggiero
AU  - Curci R
AD  - Divisions of Vascular Surgery, Maggiore Hospital, 10 Piazza Ospitale, 26900 Lodi, 
      Italy.
FAU - Giovannetti, Simona
AU  - Giovannetti S
AD  - Divisions of Vascular Surgery, Maggiore Hospital, 10 Piazza Ospitale, 26900 Lodi, 
      Italy.
FAU - D'Arrigo, Giuseppe
AU  - D'Arrigo G
AD  - Divisions of Vascular Surgery, Garibaldi-Nesima Hospital, 636 via Palermo, 95122 
      Catania, Italy.
FAU - Basile, Giusi
AU  - Basile G
AD  - Divisions of Vascular Surgery, Garibaldi-Nesima Hospital, 636 via Palermo, 95122 
      Catania, Italy.
FAU - Frigerio, Dalmazio
AU  - Frigerio D
AD  - Divisions of Vascular Surgery, Vimercate Hospital, 10 via Cosma e Damiano, 20871 
      Vimercate, Italy.
FAU - Veraldi, Gian Franco
AU  - Veraldi GF
AD  - Divisions of Vascular Surgery, University Hospital Pietro Confortini, 1 Piazzale 
      Aristide Stefani, 37126 Verona, Italy.
FAU - Mezzetto, Luca
AU  - Mezzetto L
AUID- ORCID: 0000-0002-6284-1740
AD  - Divisions of Vascular Surgery, University Hospital Pietro Confortini, 1 Piazzale 
      Aristide Stefani, 37126 Verona, Italy.
FAU - Ippoliti, Arnaldo
AU  - Ippoliti A
AD  - Department of Biomedicine and Prevention, University of Rome Tor Vergata, 1 viale 
      Montpellier, 00133 Rome, Italy.
FAU - Oddi, Fabio M
AU  - Oddi FM
AUID- ORCID: 0000-0001-8081-807X
AD  - Department of Biomedicine and Prevention, University of Rome Tor Vergata, 1 viale 
      Montpellier, 00133 Rome, Italy.
FAU - Settembrini, Alberto M
AU  - Settembrini AM
AUID- ORCID: 0000-0001-7802-1969
AD  - Divisions of Vascular Surgery, Maggiore Polyclinic Hospital Ca' Granda IRCCS and 
      Foundation, 35 via Francesco Sforza, 20122 Milan, Italy.
LA  - eng
PT  - Journal Article
DEP - 20230211
PL  - Switzerland
TA  - J Pers Med
JT  - Journal of personalized medicine
JID - 101602269
PMC - PMC9959358
OTO - NOTNLM
OT  - age
OT  - chronic limb-threatening ischemia
OT  - limb salvage
OT  - outcome
OT  - sex
COIS- The authors declare no conflict of interest.
EDAT- 2023/02/26 06:00
MHDA- 2023/02/26 06:01
PMCR- 2023/02/11
CRDT- 2023/02/25 03:15
PHST- 2022/12/08 00:00 [received]
PHST- 2023/02/08 00:00 [revised]
PHST- 2023/02/09 00:00 [accepted]
PHST- 2023/02/25 03:15 [entrez]
PHST- 2023/02/26 06:00 [pubmed]
PHST- 2023/02/26 06:01 [medline]
PHST- 2023/02/11 00:00 [pmc-release]
AID - jpm13020316 [pii]
AID - jpm-13-00316 [pii]
AID - 10.3390/jpm13020316 [doi]
PST - epublish
SO  - J Pers Med. 2023 Feb 11;13(2):316. doi: 10.3390/jpm13020316.