PMID- 36837603
OWN - NLM
STAT- MEDLINE
DCOM- 20230228
LR  - 20230228
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 59
IP  - 2
DP  - 2023 Feb 18
TI  - The Effect of Proton Pump Inhibitors on Early Implant Failure A Retrospective 
      Cohort Study.
LID - 10.3390/medicina59020402 [doi]
LID - 402
AB  - Background and Objectives: Maintenance of a firm and long-term stable 
      osseointegration is the primary goal of implant dentistry. Time is used to define 
      implant failure characteristics. Early implant failure (EIF) occurs up to one 
      year after loading. Recent studies indicated an association between proton pump 
      inhibitors (PPI) therapy and failure of osseointegration. The present study 
      assessed whether the use of PPIs is a risk factor to EIF. Materials and methods: 
      A retrospective cohort study including 687 patients and 2971 dental implants. The 
      study group (PPIs users) comprised 17.3% (119) individuals and 18.7% (555) 
      implants. The remaining cohort (82.7% (568) individuals and 81.3% (2416) 
      implants) served as control. The information was taken from the patients' files. 
      The following information was collected: age, gender, physical status, systemic 
      diseases, HbA1C values before and after implant-supported prosthesis delivery in 
      cases of diabetes mellitus, smoking, implant location, number of implants per 
      individual, bone augmentation, implant brand, length and width, and EIF. EIF was 
      defined as implant removal within a period of up to 12 months from loading. 
      Results: EIF in PPIs vs. non-PPIs users was 19.3% vs. 14.3% (p = 0.16) at patient 
      level and 5.4% vs. 3.5% at implant level (p = 0.03). Univariate analysis yielded 
      factors significantly associated with PPIs use, including older age, physical 
      status of the American Society of Anesthesiology (ASA) 3, hypertension, 
      hyperlipidemia, diabetes mellitus, osteoporosis, cardiovascular accident (CVA), 
      location (anterior mandible), shorter and narrower implants, and higher number of 
      implants per individual. Multivariate analysis yielded statistically significant 
      OR of 1.91; p = 0.01 for EIF following PPIs use and 2.3; p < 0.001 for location 
      in anterior mandible. Conclusions: Patients and their healthcare providers are 
      advised to carefully consider the potential risks of taking PPIs prior to dental 
      implant surgery. Further research is needed to confirm these risks and elucidate 
      systemic and local factors that may be involved in such outcomes.
FAU - Masri, Daya
AU  - Masri D
AUID- ORCID: 0000-0002-3808-8664
AD  - Department of Oral and Maxillofacial Surgery, School of Dentistry, Tel Aviv 
      University, Tel Aviv 6997801, Israel.
FAU - Retzkin, Noga
AU  - Retzkin N
AD  - Department of Periodontology and Implant Dentistry, School of Dentistry, Tel Aviv 
      University, Tel Aviv 6997801, Israel.
FAU - Luis Scombatti de Souza, Sergio
AU  - Luis Scombatti de Souza S
AD  - Departamento de CTBMF e Periodontia, Faculdade de Odontologia de Ribeirao 
      Preto-USP, Sao Paulo 14040904, Brazil.
FAU - Slutzkey, Gil S
AU  - Slutzkey GS
AD  - Department of Periodontology and Implant Dentistry, School of Dentistry, Tel Aviv 
      University, Tel Aviv 6997801, Israel.
FAU - Tagger-Green, Nirit
AU  - Tagger-Green N
AUID- ORCID: 0000-0003-0493-3599
AD  - Department of Periodontology and Implant Dentistry, School of Dentistry, Tel Aviv 
      University, Tel Aviv 6997801, Israel.
FAU - Naishlos, Sarit
AU  - Naishlos S
AD  - Department of Pediatric Dentistry, School of Dentistry, Tel Aviv University, Tel 
      Aviv 6997801, Israel.
FAU - Chaushu, Liat
AU  - Chaushu L
AUID- ORCID: 0000-0002-5755-7526
AD  - Department of Periodontology and Implant Dentistry, School of Dentistry, Tel Aviv 
      University, Tel Aviv 6997801, Israel.
LA  - eng
PT  - Journal Article
DEP - 20230218
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Humans
MH  - *Proton Pump Inhibitors
MH  - Retrospective Studies
MH  - *Osteoporosis
MH  - Smoking
MH  - Risk Factors
MH  - Follow-Up Studies
MH  - Treatment Outcome
PMC - PMC9961114
OTO - NOTNLM
OT  - dental implant
OT  - early implant failure
OT  - proton pump inhibitors
COIS- The authors declare no conflict of interest.
EDAT- 2023/02/26 06:00
MHDA- 2023/03/03 06:00
PMCR- 2023/02/18
CRDT- 2023/02/25 03:34
PHST- 2023/01/27 00:00 [received]
PHST- 2023/02/11 00:00 [revised]
PHST- 2023/02/16 00:00 [accepted]
PHST- 2023/02/25 03:34 [entrez]
PHST- 2023/02/26 06:00 [pubmed]
PHST- 2023/03/03 06:00 [medline]
PHST- 2023/02/18 00:00 [pmc-release]
AID - medicina59020402 [pii]
AID - medicina-59-00402 [pii]
AID - 10.3390/medicina59020402 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2023 Feb 18;59(2):402. doi: 10.3390/medicina59020402.