PMID- 36838860
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20230228
LR  - 20230228
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 28
IP  - 4
DP  - 2023 Feb 16
TI  - Calix[4]arene Derivative for Iodine Capture and Effect on Leaching of Iodine 
      through Packaging.
LID - 10.3390/molecules28041869 [doi]
LID - 1869
AB  - A hydrophobic calix[4]arene derivative was investigated for its iodine (I(2)) 
      capture efficiency from gaseous and liquid phase. The iodine uptake was followed 
      by UV-vis spectroscopy. Additionally, the influence of the calix[4]arene 
      derivative-polyolefin system on the leaching of iodine through packaging from a 
      povidone-iodine-based (PVP-I) formulation was evaluated. In fact, iodine is a 
      low-cost, multi-target, and broad-spectrum antiseptic. However, it is volatile, 
      and the extended storage of I(2)-based formulations is challenging in plastic 
      packaging. Here, we investigated the possibility of reducing the loss of I(2) 
      from an iodophor formulation by incorporating 4-tert-butylcalix 
      [4]arene-tetraacetic acid tetraethyl ester (CX) and its iodine complex in 
      high-density polyethylene (HDPE) or polypropylene (PP) via a swelling procedure. 
      Surface and bulk changes were monitored by contact angle, thermogravimetric 
      analysis (TGA), and UV-vis diffuse reflectance spectra. The barrier effect of the 
      different polymeric systems (embedded with CX, iodine-CX complex, or I2) was 
      evaluated by monitoring the I2 retention in a buffered PVP-I solution by UV-vis 
      spectroscopy. Overall, experimental data showed the capability of the 
      calix[4]arene derivative to complex iodine in solution and the solid state and a 
      significant reduction in the iodine leaching by the PP-CX systems.
FAU - Ferreri, Loredana
AU  - Ferreri L
AD  - Institute of Biomolecular Chemistry, CNR, Via Paolo Gaifami 18, 95126 Catania, 
      Italy.
FAU - Rapisarda, Marco
AU  - Rapisarda M
AD  - Institute for Polymers, Composites and Biomaterials, CNR, Via Paolo Gaifami 18, 
      95126 Catania, Italy.
FAU - Leanza, Melania
AU  - Leanza M
AD  - Institute for Polymers, Composites and Biomaterials, CNR, Via Paolo Gaifami 18, 
      95126 Catania, Italy.
FAU - Munzone, Cristina
AU  - Munzone C
AD  - Department of Chemistry, University of Catania, Viale A. Doria 6, 95125 Catania, 
      Italy.
FAU - D'Antona, Nicola
AU  - D'Antona N
AUID- ORCID: 0000-0002-1711-8262
AD  - Institute of Biomolecular Chemistry, CNR, Via Paolo Gaifami 18, 95126 Catania, 
      Italy.
FAU - Consoli, Grazia Maria Letizia
AU  - Consoli GML
AUID- ORCID: 0000-0002-9608-5138
AD  - Institute of Biomolecular Chemistry, CNR, Via Paolo Gaifami 18, 95126 Catania, 
      Italy.
FAU - Rizzarelli, Paola
AU  - Rizzarelli P
AUID- ORCID: 0000-0002-6727-4335
AD  - Institute for Polymers, Composites and Biomaterials, CNR, Via Paolo Gaifami 18, 
      95126 Catania, Italy.
FAU - Spina, Emanuela Teresa Agata
AU  - Spina ETA
AD  - Institute for Polymers, Composites and Biomaterials, CNR, Via Paolo Gaifami 18, 
      95126 Catania, Italy.
LA  - eng
GR  - G68I18000700007/PO FESR 2014-2020/
PT  - Journal Article
DEP - 20230216
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (calix(4)arene)
RN  - 9679TC07X4 (Iodine)
RN  - 85H0HZU99M (Povidone-Iodine)
RN  - 130036-26-9 (Calixarenes)
SB  - IM
MH  - *Iodine
MH  - Povidone-Iodine
MH  - Spectrum Analysis
MH  - *Calixarenes/chemistry
PMC - PMC9960756
OTO - NOTNLM
OT  - calix[4]arene
OT  - iodine capture
OT  - iodophore
OT  - plastic packaging
OT  - polyethylene
OT  - polypropylene
OT  - povidone-iodine
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript; or in the decision to publish the results.
EDAT- 2023/02/26 06:00
MHDA- 2023/02/26 06:01
PMCR- 2023/02/16
CRDT- 2023/02/25 04:00
PHST- 2023/02/02 00:00 [received]
PHST- 2023/02/13 00:00 [revised]
PHST- 2023/02/15 00:00 [accepted]
PHST- 2023/02/25 04:00 [entrez]
PHST- 2023/02/26 06:00 [pubmed]
PHST- 2023/02/26 06:01 [medline]
PHST- 2023/02/16 00:00 [pmc-release]
AID - molecules28041869 [pii]
AID - molecules-28-01869 [pii]
AID - 10.3390/molecules28041869 [doi]
PST - epublish
SO  - Molecules. 2023 Feb 16;28(4):1869. doi: 10.3390/molecules28041869.