PMID- 36839248
OWN - NLM
STAT- MEDLINE
DCOM- 20230228
LR  - 20230301
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 15
IP  - 4
DP  - 2023 Feb 10
TI  - Caloric Restriction (CR) Plus High-Nitrate Beetroot Juice Does Not Amplify 
      CR-Induced Metabolic Adaptation and Improves Vascular and Cognitive Functions in 
      Overweight Adults: A 14-Day Pilot Randomised Trial.
LID - 10.3390/nu15040890 [doi]
LID - 890
AB  - Caloric restriction (CR) and dietary nitrate supplementation are nutritional 
      interventions with pleiotropic physiological functions. This pilot study 
      investigates the combined effects of CR and nitrate-rich beetroot juice (BRJ) on 
      metabolic, vascular, and cognitive functions in overweight and obese middle-aged 
      and older adults. This was a two-arm, parallel randomized clinical trial 
      including 29 participants allocated to CR + BRJ (n = 15) or CR alone (n = 14) for 
      14 days. Body composition, resting energy expenditure (REE), and hand-grip 
      strength were measured. Resting blood pressure (BP) and microvascular endothelial 
      function were measured, and Trail-Making Test A and B were used to assess 
      cognitive function. Salivary nitrate and nitrite, and urinary nitrate and 
      8-isoprostane concentrations were measured. Changes in body composition, REE, and 
      systolic and diastolic BP were similar between the two interventions (p > 0.05). 
      The CR + BRJ intervention produced greater changes in average microvascular flux 
      (p = 0.03), NO-dependent endothelial activity (p = 0.02), and TMT-B cognitive 
      scores (p = 0.012) compared to CR alone. Changes in urinary 8-isoprostane were 
      greater in the CR + BRJ group (p = 0.02), and they were inversely associated with 
      changes in average microvascular flux (r = -0.53, p = 0.003). These preliminary 
      findings suggest that greater effects on vascular and cognitive functions could 
      be achieved by combining CR with dietary nitrate supplementation.
FAU - Alharbi, Mushari
AU  - Alharbi M
AUID- ORCID: 0000-0003-4273-9674
AD  - School of Life Sciences, The University of Nottingham Medical School, Queen's 
      Medical Centre, Nottingham NG7 2UH, UK.
AD  - Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz 
      University, Jeddah 22252, Saudi Arabia.
FAU - Chiurazzi, Martina
AU  - Chiurazzi M
AD  - Department of Clinical Medicine and Surgery, Federico II University of Naples, 
      Via S. Pansini, 5, 80131 Naples, Italy.
FAU - Nasti, Gilda
AU  - Nasti G
AUID- ORCID: 0000-0001-6436-0281
AD  - Department of Clinical Medicine and Surgery, Federico II University of Naples, 
      Via S. Pansini, 5, 80131 Naples, Italy.
FAU - Muscariello, Espedita
AU  - Muscariello E
AD  - Department of Clinical Medicine and Surgery, Federico II University of Naples, 
      Via S. Pansini, 5, 80131 Naples, Italy.
FAU - Mastantuono, Teresa
AU  - Mastantuono T
AD  - Department of Clinical Medicine and Surgery, Federico II University of Naples, 
      Via S. Pansini, 5, 80131 Naples, Italy.
FAU - Koechl, Christina
AU  - Koechl C
AD  - Human Nutrition Research Centre, Population Health Sciences Institute, Newcastle 
      University, Newcastle upon Tyne NE2 4HH, UK.
FAU - Stephan, Blossom Cm
AU  - Stephan BC
AD  - Institute of Mental Health, The University of Nottingham Medical School, 
      Nottingham NG7 2UH, UK.
AD  - Curtin School of Population Health, Curtin University, Kent Street, Bentley, WA 
      6102, Australia.
FAU - Shannon, Oliver M
AU  - Shannon OM
AD  - Human Nutrition Research Centre, Population Health Sciences Institute, Newcastle 
      University, Newcastle upon Tyne NE2 4HH, UK.
FAU - Colantuoni, Antonio
AU  - Colantuoni A
AD  - Department of Clinical Medicine and Surgery, Federico II University of Naples, 
      Via S. Pansini, 5, 80131 Naples, Italy.
FAU - Siervo, Mario
AU  - Siervo M
AD  - School of Life Sciences, The University of Nottingham Medical School, Queen's 
      Medical Centre, Nottingham NG7 2UH, UK.
AD  - Curtin School of Population Health, Curtin University, Kent Street, Bentley, WA 
      6102, Australia.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20230210
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Nitrates)
RN  - 0 (Antioxidants)
SB  - IM
MH  - Middle Aged
MH  - Humans
MH  - Aged
MH  - *Nitrates/pharmacology
MH  - Pilot Projects
MH  - Overweight
MH  - Caloric Restriction
MH  - Dietary Supplements
MH  - Blood Pressure
MH  - Antioxidants/pharmacology
MH  - Cognition
MH  - *Beta vulgaris
MH  - Double-Blind Method
MH  - Fruit and Vegetable Juices
PMC - PMC9962072
OTO - NOTNLM
OT  - caloric restriction
OT  - cognitive function
OT  - dietary nitrate
OT  - endothelial function
OT  - nitric oxide
OT  - obesity
COIS- The authors declare no conflict of interest.
EDAT- 2023/02/26 06:00
MHDA- 2023/03/03 06:00
PMCR- 2023/02/10
CRDT- 2023/02/25 04:07
PHST- 2023/01/17 00:00 [received]
PHST- 2023/02/07 00:00 [revised]
PHST- 2023/02/08 00:00 [accepted]
PHST- 2023/02/25 04:07 [entrez]
PHST- 2023/02/26 06:00 [pubmed]
PHST- 2023/03/03 06:00 [medline]
PHST- 2023/02/10 00:00 [pmc-release]
AID - nu15040890 [pii]
AID - nutrients-15-00890 [pii]
AID - 10.3390/nu15040890 [doi]
PST - epublish
SO  - Nutrients. 2023 Feb 10;15(4):890. doi: 10.3390/nu15040890.