PMID- 36841925
OWN - NLM
STAT- MEDLINE
DCOM- 20230419
LR  - 20230421
IS  - 1749-0774 (Electronic)
IS  - 0914-7470 (Print)
IS  - 0914-7470 (Linking)
VI  - 36
IP  - 3
DP  - 2023 May
TI  - Human umbilical cord mesenchymal stem cell-derived TGFBI attenuates 
      streptozotocin-induced type 1 diabetes mellitus by inhibiting T-cell 
      proliferation.
PG  - 997-1010
LID - 10.1007/s13577-023-00868-9 [doi]
AB  - MSCs have been demonstrated to have a great benefit for type 1 diabetes mellitus 
      (T1DM) due to their strong immunosuppressive and regenerative capacity. However, 
      the comprehensive mechanism is still unclear. Our previous study indicated that 
      transforming growth factor beta induced (TGFBI) is highly expressed in human 
      umbilical cord-derived mesenchymal stem or stromal cells (hUC-MSCs), which are 
      also implicated in T1DM. In this study, we found that infusion of TGFBI knockdown 
      hUC-MSCs displayed impaired therapeutic effects in T1DM mice and decreased 
      immunosuppressive capability. TGFBI knockdown hUC-MSCs could increase the 
      proportion of T-cell infiltration while increasing the expression of IFN-gamma 
      and interleukin-17A in the spleen. In addition, we also revealed that 
      hUC-MSC-derived TGFBI could repress activated T-cell proliferation by interfering 
      with G1/S checkpoint CyclinD2 expression. Our results demonstrate that TGFBI 
      plays a critical role in MSC immunologic regulation. TGFBI could be a new 
      immunoregulatory molecule controlling MSC function for new treatments of T1DM. 
      Schematic Representation of the Immunosuppression capacity of hUC-MSC by TGFBI.
CI  - (c) 2023. The Author(s).
FAU - Wu, Chushan
AU  - Wu C
AD  - Department of Pediatrics, Tianjin Medical University General Hospital, 154 Anshan 
      Road, Tianjin, 300052, People's Republic of China.
AD  - Department of Experimental Hematology and Biochemistry, Beijing Institute of 
      Radiation Medicine, 27 Taiping Road, Beijing, 100850, People's Republic of China.
FAU - Liu, Weijiang
AU  - Liu W
AD  - Department of Experimental Hematology and Biochemistry, Beijing Institute of 
      Radiation Medicine, 27 Taiping Road, Beijing, 100850, People's Republic of China.
FAU - Liu, Yuanlin
AU  - Liu Y
AD  - Department of Experimental Hematology and Biochemistry, Beijing Institute of 
      Radiation Medicine, 27 Taiping Road, Beijing, 100850, People's Republic of China.
FAU - Xu, Tingting
AU  - Xu T
AD  - Department of Pediatrics, Tianjin Medical University General Hospital, 154 Anshan 
      Road, Tianjin, 300052, People's Republic of China.
AD  - Department of Experimental Hematology and Biochemistry, Beijing Institute of 
      Radiation Medicine, 27 Taiping Road, Beijing, 100850, People's Republic of China.
FAU - Li, Man
AU  - Li M
AD  - Department of Experimental Hematology and Biochemistry, Beijing Institute of 
      Radiation Medicine, 27 Taiping Road, Beijing, 100850, People's Republic of China.
FAU - Li, Xue
AU  - Li X
AD  - Department of Experimental Hematology and Biochemistry, Beijing Institute of 
      Radiation Medicine, 27 Taiping Road, Beijing, 100850, People's Republic of China.
FAU - Wang, Yang
AU  - Wang Y
AD  - Department of Experimental Hematology and Biochemistry, Beijing Institute of 
      Radiation Medicine, 27 Taiping Road, Beijing, 100850, People's Republic of China.
FAU - Meng, Guangyu
AU  - Meng G
AD  - Department of Pediatrics, Tianjin Medical University General Hospital, 154 Anshan 
      Road, Tianjin, 300052, People's Republic of China.
AD  - Department of Experimental Hematology and Biochemistry, Beijing Institute of 
      Radiation Medicine, 27 Taiping Road, Beijing, 100850, People's Republic of China.
FAU - Li, Lu
AU  - Li L
AD  - Department of Pediatrics, Tianjin Medical University General Hospital, 154 Anshan 
      Road, Tianjin, 300052, People's Republic of China.
AD  - Department of Experimental Hematology and Biochemistry, Beijing Institute of 
      Radiation Medicine, 27 Taiping Road, Beijing, 100850, People's Republic of China.
FAU - Zheng, Rongxiu
AU  - Zheng R
AD  - Department of Pediatrics, Tianjin Medical University General Hospital, 154 Anshan 
      Road, Tianjin, 300052, People's Republic of China. rzheng@tmu.edu.cn.
FAU - Zhang, Yi
AU  - Zhang Y
AUID- ORCID: 0000-0003-2498-3948
AD  - Department of Experimental Hematology and Biochemistry, Beijing Institute of 
      Radiation Medicine, 27 Taiping Road, Beijing, 100850, People's Republic of China. 
      zhangyi612@hotmail.com.
LA  - eng
GR  - 2016YFC1000305/The National Key Research and Development Program of China/
PT  - Journal Article
DEP - 20230225
PL  - Japan
TA  - Hum Cell
JT  - Human cell
JID - 8912329
RN  - 5W494URQ81 (Streptozocin)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Humans
MH  - Animals
MH  - Mice
MH  - *Diabetes Mellitus, Type 1/genetics/therapy/metabolism
MH  - Streptozocin/metabolism/pharmacology
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Transforming Growth Factor beta/metabolism
MH  - *Mesenchymal Stem Cells/metabolism
MH  - Cell Proliferation/genetics
MH  - Umbilical Cord
PMC - PMC10110644
OTO - NOTNLM
OT  - Mesenchymal stem or stromal cells
OT  - Transforming growth factor beta induced (TGFBI)
OT  - Type 1 diabetes mellitus
COIS- The authors declare that there is no conflict of interests.
EDAT- 2023/02/27 06:00
MHDA- 2023/04/19 06:42
PMCR- 2023/02/25
CRDT- 2023/02/26 00:02
PHST- 2022/09/01 00:00 [received]
PHST- 2023/01/30 00:00 [accepted]
PHST- 2023/04/19 06:42 [medline]
PHST- 2023/02/27 06:00 [pubmed]
PHST- 2023/02/26 00:02 [entrez]
PHST- 2023/02/25 00:00 [pmc-release]
AID - 10.1007/s13577-023-00868-9 [pii]
AID - 868 [pii]
AID - 10.1007/s13577-023-00868-9 [doi]
PST - ppublish
SO  - Hum Cell. 2023 May;36(3):997-1010. doi: 10.1007/s13577-023-00868-9. Epub 2023 Feb 
      25.