PMID- 36842369
OWN - NLM
STAT- MEDLINE
DCOM- 20230316
LR  - 20230321
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Linking)
VI  - 164
DP  - 2023 Apr
TI  - The anti-inflammatory effects of aerobic exercise training in patients with type 
      2 diabetes: A systematic review and meta-analysis.
PG  - 156157
LID - S1043-4666(23)00035-2 [pii]
LID - 10.1016/j.cyto.2023.156157 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is a low-grade, chronic inflammatory 
      disease, associated with increased cardiovascular risk. The purpose of this 
      systematic review/ meta-analysis was to evaluate the effects of aerobic exercise 
      training (AET) on inflammatory markers in T2DM patients. METHODS: The literature 
      search was conducted utilizing PubMed, Web of Science, Embase, and the Cochrane 
      Library from their inception up to April 2022. We screened only for randomized 
      controlled trials (RCTs) investigating the effects of AET on C-reactive protein 
      (CRP) and adipokines: adiponectin, resistin, interleukin 6 (IL-6), tumor necrosis 
      factor-alpha (TNF-a), along with changes in anthropometric indices and glycemic 
      control in adult T2DM patients. Pooled post-exercise weighted mean differences 
      (WMDs) with 95% Confidence Intervals (CIs) were calculated for all outcomes of 
      interest between exercise-treated patients and controls. RESULTS: Twenty-six RCTs 
      involving 1239 T2DM patients were retrieved from the databases for meta-analysis. 
      The cumulative results showed that post-AET inflammatory markers were lower in 
      exercise-treated patients compared to controls regarding CRP (mg/L): WMD: -0.91; 
      95%CIs: -1.43, -0.40; p < 0.001 resistin (mg/ml): (WMD: -2.08; 95%CIs: -3.32, 
      -0.84; p < 0.001); TNF-a (pg/ml): (WMD: -2.70; 95%CIs: -4.26, -1.14; p < 0.001), 
      and IL-6 (pg/ml): (WMD: -1.05; 95%CIs: -1.68, -0.43; p < 0.001). Those effects 
      were accompanied by significant amelioration of fasting glucose (mg/dl) (WMD: 
      -13.02; 95%CIs: -25.39, -0.66; p = 0.04), HbA1c (%) (WMD: -0.51; 95%CIs: -0.73, 
      -0.28, p < 0.001), and fat mass (%) (WMD: -3.14; 95%CI: -4.71, -1.58; p < 0.001). 
      Our meta-analysis demonstrated less-consistent results for adiponectin (mug/ml), 
      (WMD: 1.00; 95%CI: -0.12, 2.12; p = 0.08) and body-mass index (kg/m(2)) (WMD: 
      -1.34; 95%CI: -2.76, 0.08; p = 0.06) tending to differ between AET and control 
      group. CONCLUSIONS: AET can significantly reduce the inflammatory burden in T2DM 
      patients. by ameliorating the circulating levels of CRP, resistin, TNF-a and 
      IL-6, even without accompanied significant weight-loss. The clinical impact of 
      those anti-inflammatory effects of AET needs to be determined.
CI  - Copyright (c) 2023 Elsevier Ltd. All rights reserved.
FAU - Papagianni, Georgia
AU  - Papagianni G
AD  - Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
FAU - Panayiotou, Chrystalla
AU  - Panayiotou C
AD  - Medical School, University of Cyprus, Nicosia, Cyprus.
FAU - Vardas, Michail
AU  - Vardas M
AD  - Medical School, University of Cyprus, Nicosia, Cyprus.
FAU - Balaskas, Nikolaos
AU  - Balaskas N
AD  - Medical School, University of Cyprus, Nicosia, Cyprus.
FAU - Antonopoulos, Constantinos
AU  - Antonopoulos C
AD  - Department of Vascular Surgery, Athens University Medical School, Attikon 
      University General Hospital, Athens, Greece.
FAU - Tachmatzidis, Dimitrios
AU  - Tachmatzidis D
AD  - Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
FAU - Didangelos, Triantafyllos
AU  - Didangelos T
AD  - Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
FAU - Lambadiari, Vaia
AU  - Lambadiari V
AD  - 2nd Department of Internal Medicine, Research Institute and Diabetes Centre, 
      Athens University Medical School, Attikon University General Hospital, Athens, 
      Greece.
FAU - Kadoglou, Nikolaos P E
AU  - Kadoglou NPE
AD  - Medical School, University of Cyprus, Nicosia, Cyprus. Electronic address: 
      kadoglou.nikolaos@ucy.ac.cy.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20230225
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Resistin)
RN  - 0 (Interleukin-6)
RN  - 0 (Adiponectin)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Resistin
MH  - Interleukin-6
MH  - Adiponectin
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - C-Reactive Protein/analysis
MH  - Tumor Necrosis Factor-alpha/therapeutic use
MH  - Anti-Inflammatory Agents/therapeutic use
MH  - Biomarkers
OTO - NOTNLM
OT  - Adipokines
OT  - Adiponectin
OT  - CRP
OT  - Exercise
OT  - IL-6
OT  - Inflammation
OT  - Resistin
OT  - TNF-a
OT  - Type 2 diabetes mellitus
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/02/27 06:00
MHDA- 2023/03/17 06:00
CRDT- 2023/02/26 18:32
PHST- 2022/08/03 00:00 [received]
PHST- 2023/01/07 00:00 [revised]
PHST- 2023/02/03 00:00 [accepted]
PHST- 2023/02/27 06:00 [pubmed]
PHST- 2023/03/17 06:00 [medline]
PHST- 2023/02/26 18:32 [entrez]
AID - S1043-4666(23)00035-2 [pii]
AID - 10.1016/j.cyto.2023.156157 [doi]
PST - ppublish
SO  - Cytokine. 2023 Apr;164:156157. doi: 10.1016/j.cyto.2023.156157. Epub 2023 Feb 25.