PMID- 36842621 OWN - NLM STAT- MEDLINE DCOM- 20230315 LR - 20230315 IS - 1873-6424 (Electronic) IS - 0269-7491 (Linking) VI - 323 DP - 2023 Apr 15 TI - Association between maternal exposure to per- and polyfluoroalkyl substances and serum markers of liver function during pregnancy in China: A mixture-based approach. PG - 121348 LID - S0269-7491(23)00350-0 [pii] LID - 10.1016/j.envpol.2023.121348 [doi] AB - Previous studies have shown that per- and polyfluoroalkyl substances (PFAS) may have hepatotoxic effects in animals. However, epidemiological evidence in humans, especially pregnant women, is limited. This study aimed to assess the association of single and multiple PFAS exposure with serum markers of liver function in pregnant women. A total of 420 pregnant women from the Guangxi Zhuang Birth Cohort were enrolled from June 2015 to April 2019. Nine PFAS were measured in the maternal serum in early pregnancy. Data for liver function biomarkers, namely, alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyltransferase (GGT), total bilirubin (TBIL), direct bilirubin (DBIL), and indirect bilirubin (IBIL), were obtained from medical records. In generalized linear model (GLM), there was a positive association of perfluorooctane sulfonate (PFOS) with ALT, perfluorodecanoic acid (PFDA) and perfluorobutanesulfonic acid (PFBS) with GGT, and perfluorohexane sulfonate (PFHxS) with TBIL and IBIL. In contrast, there was a negative association of perfluoroheptanoic acid (PFHpA) with TBIL. There were inverse U-shaped relationships of PFUnA with ALT and AST and PFDA with ALT by restricted cubic spline. The weighted quantile sum (WQS) regression model revealed the positive effects of the PFAS mixture on GGT, TBIL, DBIL, and IBIL. Bayesian kernel machine regression (BKMR) analysis confirmed that the PFAS mixture was positively associated with GGT, and PFBS was the main contributor. In addition, the BKMR model showed a positive association of individual PFBS with GGT, individual PFHxS with TBIL and IBIL, and a negative association of individual PFHpA with TBIL. Our findings provide evidence of an association between individual PFAS, PFAS mixture and maternal serum markers of liver function during pregnancy. Additionally, these findings also enhance concerns over PFAS exposure on maternal liver function and PFAS monitoring in pregnancy, reducing the effect of maternal liver dysfunction on maternal and infant health. CI - Copyright (c) 2023 Elsevier Ltd. All rights reserved. FAU - Liao, Qian AU - Liao Q AD - Department Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Tang, Peng AU - Tang P AD - Department Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Fan, Haoran AU - Fan H AD - Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Song, Yanye AU - Song Y AD - The Third Affiliated Hospital of Guangxi Medical University, Nanning, 530031, Guangxi, China. FAU - Liang, Jun AU - Liang J AD - Department Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Huang, Huishen AU - Huang H AD - Department Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Pan, Dongxiang AU - Pan D AD - Department Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Mo, Meile AU - Mo M AD - Department Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - LeiLei AU - LeiLei AD - Department Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Lin, Mengrui AU - Lin M AD - Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Chen, Jiehua AU - Chen J AD - Department Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Wei, Huanni AU - Wei H AD - Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Long, Jinghua AU - Long J AD - Department Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Shao, Yantao AU - Shao Y AD - Department of Medical and Health Management, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Zeng, Xiaoyun AU - Zeng X AD - Department Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Liu, Shun AU - Liu S AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Huang, Dongping AU - Huang D AD - Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. FAU - Qiu, Xiaoqiang AU - Qiu X AD - Department Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. Electronic address: xqqiu9999@163.com. LA - eng PT - Journal Article DEP - 20230224 PL - England TA - Environ Pollut JT - Environmental pollution (Barking, Essex : 1987) JID - 8804476 RN - 0 (Environmental Pollutants) RN - 0 (Fluorocarbons) RN - 335-76-2 (perfluorodecanoic acid) RN - 0 (Alkanesulfonic Acids) RN - 0 (perfluorobutanesulfonic acid) RN - 375-85-9 (perfluoro-n-heptanoic acid) RN - FX3WJ41CMX (perflexane) RN - 0 (Alkanesulfonates) SB - IM MH - Infant MH - Animals MH - Humans MH - Female MH - Pregnancy MH - Maternal Exposure MH - *Environmental Pollutants/toxicity MH - Bayes Theorem MH - China/epidemiology MH - *Fluorocarbons/toxicity MH - *Alkanesulfonic Acids MH - Alkanesulfonates OTO - NOTNLM OT - Guangxi Zhuang birth cohort OT - Liver function OT - Mixture OT - Per- and polyfluoroalkyl substances COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/02/27 06:00 MHDA- 2023/03/16 06:00 CRDT- 2023/02/26 19:29 PHST- 2022/11/02 00:00 [received] PHST- 2023/02/12 00:00 [revised] PHST- 2023/02/22 00:00 [accepted] PHST- 2023/02/27 06:00 [pubmed] PHST- 2023/03/16 06:00 [medline] PHST- 2023/02/26 19:29 [entrez] AID - S0269-7491(23)00350-0 [pii] AID - 10.1016/j.envpol.2023.121348 [doi] PST - ppublish SO - Environ Pollut. 2023 Apr 15;323:121348. doi: 10.1016/j.envpol.2023.121348. Epub 2023 Feb 24.