PMID- 36843019
OWN - NLM
STAT- MEDLINE
DCOM- 20230331
LR  - 20230429
IS  - 1347-7439 (Electronic)
IS  - 0916-7250 (Print)
IS  - 0916-7250 (Linking)
VI  - 85
IP  - 4
DP  - 2023 Mar 30
TI  - Effects of burdock inulin-type fructans exposure on the physiological function of 
      healthy mice and their filial generation.
PG  - 425-433
LID - 10.1292/jvms.22-0530 [doi]
AB  - Inulin-type fructans (ITFs) have been shown to possess various biological 
      activities. However, studies on their safety and side effects are limited. Hence, 
      we aimed to evaluate the possible effects of burdock ITFs on the physiological 
      indices of healthy mice and their filial generation when fed for six months. 
      Thirty-two C57BL/6J mice were randomly divided into two groups; a normal control 
      (NC) and an ITFs group. The parental generations were kept in one cage with free 
      access to a normal diet and double-distilled water (P-NC group) or burdock ITFs 
      drinking water (P-ITFs group, 2% w/v). The filial generations (F-NC group and 
      F-ITFs group) were kept separately and were fed as their parental generation. 
      Behavior, organ/body weight, serum indices, histopathology, time of production, 
      and number of pup births were observed. There were no significant adverse effects 
      on these indices. Functional indices of the spleen, lung, heart, and pancreas of 
      the ITFs groups were higher than those of the NC groups, respectively. 
      Interestingly, the serum glucose (GLU), total cholesterol (TC), uric acid (UA) 
      and creatine kinase (CK) levels of the ITFs groups were lower than those of the 
      NC groups. Meanwhile, the pregnancy number and pup birth number of the P-ITFs 
      group were more than those of P-NC group. Therefore, long-term consumption of 
      burdock ITFs has no obvious adverse effects on the health of parental mice and 
      their offspring, but may contribute to reproductive capacity, fatigue reduction, 
      and risk reduction of renal disease.
FAU - Liu, Chunyan
AU  - Liu C
AD  - Anhui Provincial Engineering Research Center for Polysaccharide Drugs, Anhui 
      Provincial Engineering Laboratory for Screening and Re-evaluation of Active 
      Compounds of Herbal Medicines in Southern Anhui, Anhui Province Key Laboratory of 
      Active Biological Macromolecules, Wuhu, China.
AD  - Drug Research & Development Center, School of Pharmacy, Wannan Medical College, 
      Wuhu, China.
FAU - Yuan, Pingchuan
AU  - Yuan P
AD  - Anhui Provincial Engineering Research Center for Polysaccharide Drugs, Anhui 
      Provincial Engineering Laboratory for Screening and Re-evaluation of Active 
      Compounds of Herbal Medicines in Southern Anhui, Anhui Province Key Laboratory of 
      Active Biological Macromolecules, Wuhu, China.
AD  - Drug Research & Development Center, School of Pharmacy, Wannan Medical College, 
      Wuhu, China.
FAU - Wang, Ying
AU  - Wang Y
AD  - Drug Research & Development Center, School of Pharmacy, Wannan Medical College, 
      Wuhu, China.
FAU - Yang, Xuelian
AU  - Yang X
AD  - Drug Research & Development Center, School of Pharmacy, Wannan Medical College, 
      Wuhu, China.
FAU - Xu, Yudie
AU  - Xu Y
AD  - Drug Research & Development Center, School of Pharmacy, Wannan Medical College, 
      Wuhu, China.
FAU - Zhang, Wenzhi
AU  - Zhang W
AD  - Drug Research & Development Center, School of Pharmacy, Wannan Medical College, 
      Wuhu, China.
FAU - Han, Xue
AU  - Han X
AD  - Wuhu Medical and Health School, Wuhu, China.
FAU - Chen, Kaoshan
AU  - Chen K
AD  - Anhui Provincial Engineering Research Center for Polysaccharide Drugs, Anhui 
      Provincial Engineering Laboratory for Screening and Re-evaluation of Active 
      Compounds of Herbal Medicines in Southern Anhui, Anhui Province Key Laboratory of 
      Active Biological Macromolecules, Wuhu, China.
AD  - Drug Research & Development Center, School of Pharmacy, Wannan Medical College, 
      Wuhu, China.
FAU - Wang, Guodong
AU  - Wang G
AD  - Anhui Provincial Engineering Research Center for Polysaccharide Drugs, Anhui 
      Provincial Engineering Laboratory for Screening and Re-evaluation of Active 
      Compounds of Herbal Medicines in Southern Anhui, Anhui Province Key Laboratory of 
      Active Biological Macromolecules, Wuhu, China.
AD  - Drug Research & Development Center, School of Pharmacy, Wannan Medical College, 
      Wuhu, China.
FAU - Shao, Taili
AU  - Shao T
AD  - Anhui Provincial Engineering Research Center for Polysaccharide Drugs, Anhui 
      Provincial Engineering Laboratory for Screening and Re-evaluation of Active 
      Compounds of Herbal Medicines in Southern Anhui, Anhui Province Key Laboratory of 
      Active Biological Macromolecules, Wuhu, China.
AD  - Drug Research & Development Center, School of Pharmacy, Wannan Medical College, 
      Wuhu, China.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial, Veterinary
DEP - 20230327
PL  - Japan
TA  - J Vet Med Sci
JT  - The Journal of veterinary medical science
JID - 9105360
RN  - 9005-80-5 (Inulin)
RN  - 0 (Fructans)
SB  - IM
MH  - Pregnancy
MH  - Female
MH  - Mice
MH  - Animals
MH  - *Inulin/pharmacology
MH  - Fructans/pharmacology
MH  - *Arctium
MH  - Mice, Inbred C57BL
MH  - Reproduction
PMC - PMC10139783
OTO - NOTNLM
OT  - burdock
OT  - inulin-type fructans
OT  - physiology
OT  - safety
COIS- The authors have no conflicts of interest.
EDAT- 2023/02/28 06:00
MHDA- 2023/03/31 06:41
PMCR- 2023/04/01
CRDT- 2023/02/27 00:28
PHST- 2023/03/31 06:41 [medline]
PHST- 2023/02/28 06:00 [pubmed]
PHST- 2023/02/27 00:28 [entrez]
PHST- 2023/04/01 00:00 [pmc-release]
AID - 22-0530 [pii]
AID - 10.1292/jvms.22-0530 [doi]
PST - ppublish
SO  - J Vet Med Sci. 2023 Mar 30;85(4):425-433. doi: 10.1292/jvms.22-0530. Epub 2023 
      Mar 27.