PMID- 36845043
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230228
IS  - 2296-861X (Print)
IS  - 2296-861X (Electronic)
IS  - 2296-861X (Linking)
VI  - 10
DP  - 2023
TI  - A rose flavor compound activating the NRF2 pathway in dendritic cells ameliorates 
      contact hypersensitivity in mice.
PG  - 1081263
LID - 10.3389/fnut.2023.1081263 [doi]
LID - 1081263
AB  - Dendritic cells (DCs), which are typical antigen-presenting cells, localize to 
      various sites in the body, particularly the front line of infection as sentinels, 
      and are involved in innate and adaptive immune responses. Although the functions 
      of DCs, such as pathogen-induced cytokine production and antigen-specific T cell 
      activation, are important for host defenses against infection and tumorigenesis, 
      the hyper- and/or extended activation of DCs leads to inflammatory and autoimmune 
      diseases. In the present study, beta-damascone, a major ingredient of rose 
      fragrance, was selected from an aroma library as a candidate compound that 
      suppresses antigen-induced immune responses. beta-Damascone inhibited the functions 
      of DCs, including the antigen-dependent proliferation of T cells, DC-induced Th1 
      development, and the TLR ligand-induced production of inflammatory cytokines by 
      DCs. The beta-damascone treatment also increased the protein level of the 
      transcription factor NF-E2-related factor 2 (NRF2), which plays key roles in 
      antioxidant responses, and the transcription of Hmox1 and Nqo1, target genes of 
      NRF2, in DCs. Nrf2 (-/) (-) DCs induced Th1-development and produced large amount 
      of IL-12p40 even in the presence of beta-damascone, whereas these functions by Nrf2 
      (+/-) DCs were inhibited by beta-damascone under the same conditions. The intake of 
      beta-damascone suppressed ear swelling in contact hypersensitivity (CHS) model mice, 
      but not in CHS-induced Nrf2 (-/) (-) mice. Collectively, the present results 
      indicate the potential of the rose aroma compound beta-damascone, which suppresses 
      DC-mediated immune responses by activating the NRF2 pathway in DCs, for the 
      prevention and/or attenuation of immune-mediated diseases.
CI  - Copyright (c) 2023 Kodama, Okada, Hachisu, Ando, Ito, Nagata, Katagiri, Yasuda, 
      Hiroki, Yashiro, Ichihara, Yamamoto and Nishiyama.
FAU - Kodama, Naoki
AU  - Kodama N
AD  - Department of Biological Science and Technology, Faculty of Advanced Engineering, 
      Tokyo University of Science, Tokyo, Japan.
FAU - Okada, Hikaru
AU  - Okada H
AD  - Department of Biological Science and Technology, Faculty of Advanced Engineering, 
      Tokyo University of Science, Tokyo, Japan.
FAU - Hachisu, Masakazu
AU  - Hachisu M
AD  - Department of Biological Science and Technology, Faculty of Advanced Engineering, 
      Tokyo University of Science, Tokyo, Japan.
FAU - Ando, Miki
AU  - Ando M
AD  - Department of Biological Science and Technology, Faculty of Advanced Engineering, 
      Tokyo University of Science, Tokyo, Japan.
FAU - Ito, Naoto
AU  - Ito N
AD  - Department of Biological Science and Technology, Faculty of Advanced Engineering, 
      Tokyo University of Science, Tokyo, Japan.
FAU - Nagata, Kazuki
AU  - Nagata K
AD  - Department of Biological Science and Technology, Faculty of Advanced Engineering, 
      Tokyo University of Science, Tokyo, Japan.
FAU - Katagiri, Mayuka
AU  - Katagiri M
AD  - Department of Biological Science and Technology, Faculty of Advanced Engineering, 
      Tokyo University of Science, Tokyo, Japan.
FAU - Yasuda, Yayoi
AU  - Yasuda Y
AD  - Department of Biological Science and Technology, Faculty of Advanced Engineering, 
      Tokyo University of Science, Tokyo, Japan.
FAU - Hiroki, Ikumi
AU  - Hiroki I
AD  - Department of Biological Science and Technology, Faculty of Advanced Engineering, 
      Tokyo University of Science, Tokyo, Japan.
FAU - Yashiro, Takuya
AU  - Yashiro T
AD  - Department of Biological Science and Technology, Faculty of Advanced Engineering, 
      Tokyo University of Science, Tokyo, Japan.
FAU - Ichihara, Gaku
AU  - Ichihara G
AD  - Department of Occupational and Environmental Health, Faculty of Pharmaceutical 
      Sciences, Tokyo University of Science, Chiba, Japan.
FAU - Yamamoto, Masayuki
AU  - Yamamoto M
AD  - Department of Medical Biochemistry, Tohoku University Graduate School of 
      Medicine, Sendai, Japan.
FAU - Nishiyama, Chiharu
AU  - Nishiyama C
AD  - Department of Biological Science and Technology, Faculty of Advanced Engineering, 
      Tokyo University of Science, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20230209
PL  - Switzerland
TA  - Front Nutr
JT  - Frontiers in nutrition
JID - 101642264
PMC - PMC9946980
OTO - NOTNLM
OT  - NRF2
OT  - aroma
OT  - contact hypersensitivity
OT  - dendritic cell
OT  - rose
OT  - beta-damascone
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/02/28 06:00
MHDA- 2023/02/28 06:01
PMCR- 2023/01/01
CRDT- 2023/02/27 04:53
PHST- 2022/10/27 00:00 [received]
PHST- 2023/01/23 00:00 [accepted]
PHST- 2023/02/27 04:53 [entrez]
PHST- 2023/02/28 06:00 [pubmed]
PHST- 2023/02/28 06:01 [medline]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fnut.2023.1081263 [doi]
PST - epublish
SO  - Front Nutr. 2023 Feb 9;10:1081263. doi: 10.3389/fnut.2023.1081263. eCollection 
      2023.