PMID- 36845247
OWN - NLM
STAT- MEDLINE
DCOM- 20230306
LR  - 20230306
IS  - 1937-8688 (Electronic)
VI  - 42
DP  - 2022
TI  - Prevalence of cardiovascular risk factors and their association with renal 
      impairment in elderly patients with type 2 diabetes mellitus in a Nigerian 
      tertiary hospital: a cross-sectional study.
PG  - 233
LID - 10.11604/pamj.2022.42.233.35265 [doi]
LID - 233
AB  - INTRODUCTION: the population of elderly with Type 2 Diabetes Mellitus (T2DM) has 
      been on the increase. The burden of cardiovascular disease and renal impairment 
      may also increase due to the relationship between cardiovascular risk factors and 
      ageing in those with T2DM. The prevalence of cardiovascular risk factors and 
      their association with renal impairment in elderly with T2DM were determined. 
      METHODS: this is a cross-sectional study that involved 96 elderly patients with 
      T2DM and 96 elderly individuals without DM as control. The prevalence of 
      cardiovascular risk factors was determined among the study participants. Binary 
      logistic regression was used to determine the significant cardiovascular factors 
      associated with renal impairment among the elderly with T2DM. P-value <0.05 was 
      taken as significant. RESULTS: the mean age of the elderly with T2DM and control 
      group were 66.73+/-5.18 years and 66.78+/-5.25years, respectively. The male: female 
      ratio was 1: 1 for both groups. The prevalence of the cardiovascular risk factors 
      in the elderly with T2DM and control were; hypertension (72.9%vs39.6%; p </=0.001), 
      high glycated haemoglobin (77.1% vs 0%; p </=0.001), generalized obesity 
      (34.4%vs1.0%; p </=0.001), central obesity (50.0%vs11.5%; p </=0.001), dyslipidemia 
      (97.9%vs89.6%; p=0.016), albuminuria (69.8% vs 11.2%; p </=0.001), anaemia 
      (53.1%vs18.8%; p </=0.001). Renal impairment was present in 44.8% of the elderly 
      T2DM. On multivariate analysis, the cardiovascular risk factors significantly 
      associated with renal impairment in elderly with T2DM were high glycated 
      haemoglobin (aOR: 6.21, 95% CI: 1.61-24.04; p=0.008), albuminuria (aOR: 4.77, 95% 
      CI: 1.59-14.31; p=0.005) and obesity (aOR: 2.78, 95%CI 1.04-7.45; p=0.042). 
      CONCLUSION: cardiovascular risks factors were highly prevalent and closely 
      associated with renal impairment in elderly with T2DM. Early cardiovascular risk 
      factor modification may reduce both renal and cardiovascular disease burden.
CI  - Copyright: Oladimeji Adedeji Junaid et al.
FAU - Junaid, Oladimeji Adedeji
AU  - Junaid OA
AD  - Department of Internal Medicine, University of Medical Sciences, Ondo State, 
      Nigeria.
FAU - Ojo, Olubukola Ayoola
AU  - Ojo OA
AD  - Department of Internal Medicine, Federal Medical Centre, Owo, Ondo State, 
      Nigeria.
FAU - Adejumo, Oluseyi Ademola
AU  - Adejumo OA
AD  - Department of Internal Medicine, University of Medical Sciences, Ondo State, 
      Nigeria.
FAU - Junaid, Folorunsho Mansally
AU  - Junaid FM
AD  - The Royal Wolverhampton NHS Trust, Wolverhampton, United Kingdom.
FAU - Owolade, Sunday Samson
AU  - Owolade SS
AD  - Department of Internal Medicine, University of Medical Sciences, Ondo State, 
      Nigeria.
FAU - Ojo, Olalekan Ezekiel
AU  - Ojo OE
AD  - Department of Internal Medicine, Federal Medical Centre, Owo, Ondo State, 
      Nigeria.
FAU - Kolawole, Babatope Ayodeji
AU  - Kolawole BA
AD  - Department of Internal Medicine, Obafemi Awolowo University, Ile-Ife, Osun State, 
      Nigeria.
FAU - Ikem, Temidayo Rosemary
AU  - Ikem TR
AD  - Department of Internal Medicine, Obafemi Awolowo University, Ile-Ife, Osun State, 
      Nigeria.
LA  - eng
PT  - Journal Article
DEP - 20220726
PL  - Uganda
TA  - Pan Afr Med J
JT  - The Pan African medical journal
JID - 101517926
RN  - 0 (Glycated Hemoglobin)
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Albuminuria/epidemiology
MH  - *Cardiovascular Diseases/epidemiology/etiology
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Glycated Hemoglobin
MH  - *Heart Disease Risk Factors
MH  - Obesity/complications/epidemiology
MH  - Prevalence
MH  - *Renal Insufficiency/epidemiology/etiology
MH  - Risk Factors
MH  - Tertiary Care Centers
MH  - Nigeria/epidemiology
PMC - PMC9949284
OTO - NOTNLM
OT  - Elderly
OT  - cardiovascular risk factor
OT  - renal impairment
OT  - type 2 diabetes mellitus
COIS- The authors declare no competing interests.
EDAT- 2023/02/28 06:00
MHDA- 2023/03/03 06:00
PMCR- 2022/07/26
CRDT- 2023/02/27 05:00
PHST- 2022/05/02 00:00 [received]
PHST- 2022/07/04 00:00 [accepted]
PHST- 2023/02/27 05:00 [entrez]
PHST- 2023/02/28 06:00 [pubmed]
PHST- 2023/03/03 06:00 [medline]
PHST- 2022/07/26 00:00 [pmc-release]
AID - PAMJ-42-233 [pii]
AID - 10.11604/pamj.2022.42.233.35265 [doi]
PST - epublish
SO  - Pan Afr Med J. 2022 Jul 26;42:233. doi: 10.11604/pamj.2022.42.233.35265. 
      eCollection 2022.