PMID- 36845652
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230228
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 15
DP  - 2023
TI  - Clinical antidiabetic medication used in Alzheimer's disease: From basic 
      discovery to therapeutics development.
PG  - 1122300
LID - 10.3389/fnagi.2023.1122300 [doi]
LID - 1122300
AB  - Alzheimer's disease (AD) is a common neurodegenerative disease. Type 2 diabetes 
      mellitus (T2DM) appears to increase and contributing to the risk of AD. 
      Therefore, there is increasing concern about clinical antidiabetic medication 
      used in AD. Most of them show some potential in basic research, but not in 
      clinical research. So we reviewed the opportunities and challenges faced by some 
      antidiabetic medication used in AD from basic to clinical research. Based on 
      existing research progress, this is still the hope of some patients with special 
      types of AD caused by rising blood glucose or/and insulin resistance.
CI  - Copyright (c) 2023 Huang, Huang, Cui, Shi and Qiu.
FAU - Huang, Juan
AU  - Huang J
AD  - Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University 
      School of Medicine, Shanghai, China.
AD  - Key Laboratory of Basic Pharmacology of Ministry of Education and Joint 
      International Research Laboratory of Ethnomedicine of Ministry of Education, 
      Zunyi Medical University, Zunyi, Guizhou, China.
AD  - School of Public Health, Zunyi Medical University, Zunyi, Guizhou, China.
FAU - Huang, Nanqu
AU  - Huang N
AD  - The Third Affiliated Hospital of Zunyi Medical University (The First People's 
      Hospital of Zunyi), Zunyi, Guizhou, China.
FAU - Cui, Di
AU  - Cui D
AD  - Key Laboratory of Basic Pharmacology of Ministry of Education and Joint 
      International Research Laboratory of Ethnomedicine of Ministry of Education, 
      Zunyi Medical University, Zunyi, Guizhou, China.
FAU - Shi, Jingshan
AU  - Shi J
AD  - Key Laboratory of Basic Pharmacology of Ministry of Education and Joint 
      International Research Laboratory of Ethnomedicine of Ministry of Education, 
      Zunyi Medical University, Zunyi, Guizhou, China.
FAU - Qiu, Yu
AU  - Qiu Y
AD  - Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University 
      School of Medicine, Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230210
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC9950577
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - antidiabetic medication
OT  - clinical research
OT  - type 2 diabetes mellitus
OT  - type 3 diabetes mellitus (T3DM)
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/02/28 06:00
MHDA- 2023/02/28 06:01
PMCR- 2023/01/01
CRDT- 2023/02/27 05:17
PHST- 2022/12/12 00:00 [received]
PHST- 2023/01/30 00:00 [accepted]
PHST- 2023/02/27 05:17 [entrez]
PHST- 2023/02/28 06:00 [pubmed]
PHST- 2023/02/28 06:01 [medline]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2023.1122300 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2023 Feb 10;15:1122300. doi: 10.3389/fnagi.2023.1122300. 
      eCollection 2023.