PMID- 36846137
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230228
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 14
DP  - 2023
TI  - Research progress on the protective mechanism of a novel soluble epoxide 
      hydrolase inhibitor TPPU on ischemic stroke.
PG  - 1083972
LID - 10.3389/fneur.2023.1083972 [doi]
LID - 1083972
AB  - Arachidonic Acid (AA) is the precursor of cerebrovascular active substances in 
      the human body, and its metabolites are closely associated with the pathogenesis 
      of cerebrovascular diseases. In recent years, the cytochrome P450 (CYP) metabolic 
      pathway of AA has become a research hotspot. Furthermore, the CYP metabolic 
      pathway of AA is regulated by soluble epoxide hydrolase (sEH). 
      1-trifluoromethoxyphenyl-3(1-propionylpiperidin-4-yl) urea (TPPU) is a novel sEH 
      inhibitor that exerts cerebrovascular protective activity. This article reviews 
      the mechanism of TPPU's protective effect on ischemic stroke disease.
CI  - Copyright (c) 2023 Huang.
FAU - Huang, Pan
AU  - Huang P
AD  - Department of Neurology, People's Hospital of Deyang City, Deyang, Sichuan, 
      China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230208
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC9945277
OTO - NOTNLM
OT  - TPPU
OT  - arachidonic acid
OT  - blood-brain barrier
OT  - ischemia reperfusion
OT  - ischemic stroke
COIS- The author declares that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/02/28 06:00
MHDA- 2023/02/28 06:01
PMCR- 2023/02/08
CRDT- 2023/02/27 05:39
PHST- 2022/10/29 00:00 [received]
PHST- 2023/01/20 00:00 [accepted]
PHST- 2023/02/27 05:39 [entrez]
PHST- 2023/02/28 06:00 [pubmed]
PHST- 2023/02/28 06:01 [medline]
PHST- 2023/02/08 00:00 [pmc-release]
AID - 10.3389/fneur.2023.1083972 [doi]
PST - epublish
SO  - Front Neurol. 2023 Feb 8;14:1083972. doi: 10.3389/fneur.2023.1083972. eCollection 
      2023.