PMID- 36846307
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230228
IS  - 2590-0064 (Electronic)
IS  - 2590-0064 (Linking)
VI  - 19
DP  - 2023 Apr
TI  - Mannose-coated superparamagnetic iron oxide nanozyme for preventing postoperative 
      cognitive dysfunction.
PG  - 100568
LID - 10.1016/j.mtbio.2023.100568 [doi]
LID - 100568
AB  - Postoperative cognitive dysfunction (POCD) is associated with increased 
      postoperative morbidity and mortality in patients. Excessive production of 
      reactive oxygen species (ROS) and the consequent inflammatory response in the 
      postoperative brain play crucial roles in the development of POCD. However, 
      effective ways to prevent POCD have yet to be developed. Moreover, effective 
      penetration of the blood-brain barrier (BBB) and maintaining viability in vivo 
      are major challenges for preventing POCD using traditional ROS scavengers. 
      Herein, mannose-coated superparamagnetic iron oxide nanoparticles (mSPIONs) were 
      synthesized by co-precipitation method. The BBB penetration of mSPIONs was 
      verified through fluorescent imaging and ICP-MS quantification. The ROS 
      scavenging and anti-inflammatory of mSPIONs were evaluated in H(2)O(2)-treated 
      J774A.1 ​cells and in tibial fracture mice model. The novel object recognition 
      (NOR) and trace-fear conditioning (TFC) were used to test the cognitive function 
      of postoperative mice. The average diameter of mSPIONs was approximately 11 ​nm. 
      mSPIONs significantly reduced ROS levels in H(2)O(2)-treated cells and in 
      hippocampus of surgical mice. mSPIONs administration reduced the levels of IL-1beta 
      and TNF-alpha in the hippocampus and inhibited surgery-upregulated HIF1-alpha/NF-kappaB 
      signaling pathway. Moreover, mSPIONs significantly improved the cognitive 
      function of postoperative mice. This study provides a new approach for preventing 
      POCD using a nanozyme.
CI  - (c) 2023 The Authors.
FAU - Zhu, Qianyun
AU  - Zhu Q
AD  - Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical 
      University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui 
      Higher Education Institutes, Anhui Medical University, Hefei, PR China.
FAU - Huang, Yuting
AU  - Huang Y
AD  - Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical 
      University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui 
      Higher Education Institutes, Anhui Medical University, Hefei, PR China.
FAU - Zhu, Xiaoling
AU  - Zhu X
AD  - Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical 
      University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui 
      Higher Education Institutes, Anhui Medical University, Hefei, PR China.
FAU - Peng, Lijun
AU  - Peng L
AD  - Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical 
      University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui 
      Higher Education Institutes, Anhui Medical University, Hefei, PR China.
FAU - Wang, Huan
AU  - Wang H
AD  - Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical 
      University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui 
      Higher Education Institutes, Anhui Medical University, Hefei, PR China.
FAU - Gao, Shan
AU  - Gao S
AD  - Department of Pharmacology, Basic Medical College, Anhui Medical University, 
      Hefei, PR China.
FAU - Yang, Zhilai
AU  - Yang Z
AD  - Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical 
      University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui 
      Higher Education Institutes, Anhui Medical University, Hefei, PR China.
FAU - Zhang, Jiqian
AU  - Zhang J
AD  - Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical 
      University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui 
      Higher Education Institutes, Anhui Medical University, Hefei, PR China.
FAU - Liu, Xuesheng
AU  - Liu X
AD  - Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical 
      University, Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui 
      Higher Education Institutes, Anhui Medical University, Hefei, PR China.
LA  - eng
PT  - Journal Article
DEP - 20230214
PL  - England
TA  - Mater Today Bio
JT  - Materials today. Bio
JID - 101757228
PMC - PMC9945786
OTO - NOTNLM
OT  - Nanoparticles
OT  - Neuroinflammation
OT  - Postoperative cognitive dysfunction
OT  - Reactive oxygen species
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2023/02/28 06:00
MHDA- 2023/02/28 06:01
PMCR- 2023/02/14
CRDT- 2023/02/27 05:47
PHST- 2022/10/30 00:00 [received]
PHST- 2023/01/18 00:00 [revised]
PHST- 2023/01/27 00:00 [accepted]
PHST- 2023/02/27 05:47 [entrez]
PHST- 2023/02/28 06:00 [pubmed]
PHST- 2023/02/28 06:01 [medline]
PHST- 2023/02/14 00:00 [pmc-release]
AID - S2590-0064(23)00028-5 [pii]
AID - 100568 [pii]
AID - 10.1016/j.mtbio.2023.100568 [doi]
PST - epublish
SO  - Mater Today Bio. 2023 Feb 14;19:100568. doi: 10.1016/j.mtbio.2023.100568. 
      eCollection 2023 Apr.