PMID- 36848746
OWN - NLM
STAT- MEDLINE
DCOM- 20230320
LR  - 20240402
IS  - 1879-0372 (Electronic)
IS  - 0952-7915 (Print)
IS  - 0952-7915 (Linking)
VI  - 81
DP  - 2023 Apr
TI  - Recent insights into the mechanisms of anaphylaxis.
PG  - 102288
LID - S0952-7915(23)00007-9 [pii]
LID - 10.1016/j.coi.2023.102288 [doi]
AB  - Anaphylaxis is an acute life-threatening systemic allergic reaction that can have 
      a wide range of clinical manifestations. The most common triggers for anaphylaxis 
      include food, medication, and venom. What is curious regarding anaphylaxis is how 
      so many different agents can induce a severe systemic clinical response but only 
      in a select subgroup of patients. Over the past decade, several important 
      advances have been made in understanding the underlying cellular and molecular 
      mechanisms contributing to anaphylaxis, with mast cells (MCs) being an essential 
      component. Classically, cross-linked immunoglobulin E (IgE) bound to its high- 
      affinity receptor induces MC mediator release. However, toll-like, complement, or 
      Mas-related G-protein-coupled receptors also activate mouse and human MCs. While 
      anaphylaxis secondary to foods historically has been more extensively 
      characterized clinically and mechanistically, more recent studies have shifted 
      focus toward understanding drug-induced anaphylaxis. The focus of this review is 
      to highlight recent basic science developments and compare what is currently 
      known regarding anaphylaxis to food, medications, and venom.
CI  - Copyright (c) 2023 Elsevier Ltd. All rights reserved.
FAU - Stevens, Whitney W
AU  - Stevens WW
AD  - Division of Allergy and Immunology, Department of Medicine, Northwestern 
      University Feinberg School of Medicine, Chicago, IL, USA. Electronic address: 
      whitney-stevens@northwestern.edu.
FAU - Kraft, Magdalena
AU  - Kraft M
AD  - Division of Allergy and Immunology, Department of Medicine, Northwestern 
      University Feinberg School of Medicine, Chicago, IL, USA.
FAU - Eisenbarth, Stephanie C
AU  - Eisenbarth SC
AD  - Division of Allergy and Immunology, Department of Medicine, Northwestern 
      University Feinberg School of Medicine, Chicago, IL, USA. Electronic address: 
      stephanie.eisenbarth@northwestern.edu.
LA  - eng
GR  - K23 AI141694/AI/NIAID NIH HHS/United States
GR  - R01 AI136942/AI/NIAID NIH HHS/United States
GR  - R56 AI155497/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230226
PL  - England
TA  - Curr Opin Immunol
JT  - Current opinion in immunology
JID - 8900118
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (Allergens)
SB  - IM
MH  - Humans
MH  - Mice
MH  - Animals
MH  - *Anaphylaxis/metabolism
MH  - Immunoglobulin E/metabolism
MH  - *Drug Hypersensitivity/metabolism
MH  - Mast Cells
MH  - Receptors, G-Protein-Coupled/metabolism
MH  - Allergens
PMC - PMC10023498
MID - NIHMS1871697
COIS- Conflict of Interest Disclosure: W. Stevens has served as an advisor to 
      GlaxoSmithKline, Bristol Myers Squibb, Genentech, and Regeneron. M. Kraft reports 
      travel support from ALK-Abello and speaker honoraria from Bencard Allergie GmbH, 
      outside the submitted work. Magdalena Kraft and Stephanie Eisenbarth have nothing 
      to report.
EDAT- 2023/02/28 06:00
MHDA- 2023/03/21 06:00
PMCR- 2024/04/01
CRDT- 2023/02/27 18:19
PHST- 2022/11/10 00:00 [received]
PHST- 2023/01/24 00:00 [revised]
PHST- 2023/01/25 00:00 [accepted]
PHST- 2023/02/28 06:00 [pubmed]
PHST- 2023/03/21 06:00 [medline]
PHST- 2023/02/27 18:19 [entrez]
PHST- 2024/04/01 00:00 [pmc-release]
AID - S0952-7915(23)00007-9 [pii]
AID - 10.1016/j.coi.2023.102288 [doi]
PST - ppublish
SO  - Curr Opin Immunol. 2023 Apr;81:102288. doi: 10.1016/j.coi.2023.102288. Epub 2023 
      Feb 26.