PMID- 36848775
OWN - NLM
STAT- MEDLINE
DCOM- 20230316
LR  - 20230401
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Linking)
VI  - 160
DP  - 2023 Apr
TI  - GRIN2B gene expression is increased in the anterior cingulate cortex in major 
      depression.
PG  - 204-209
LID - S0022-3956(23)00076-6 [pii]
LID - 10.1016/j.jpsychires.2023.02.017 [doi]
AB  - The glutamatergic system may be central to the neurobiology and treatment of 
      major depressive disorder (MDD) and psychosis. Despite the success of 
      N-methyl-D-aspartate receptor (NMDAR) antagonists for the treatment of MDD, 
      little is known regarding the expression of these glutamate receptors in MDD. In 
      this study we measured gene expression, via qRT-PCR, of the major NMDAR subunits, 
      in the anterior cingulate cortex (ACC) in MDD subjects with and without 
      psychosis, and non-psychiatric controls. Overall, GRIN2B mRNA was increased in 
      both MDD with (+32%) and without psychosis (+40%) compared to controls along with 
      a trend increase in GRIN1 mRNA in MDD overall (+24%). Furthermore, in MDD with 
      psychosis there was a significant decrease in the GRIN2A:GRIN2B mRNA ratio 
      (-19%). Collectively these results suggest dysfunction of the glutamatergic 
      system at the gene expression level in the ACC in MDD. Increased GRIN2B mRNA in 
      MDD, along with an altered GRIN2A:GRIN2B ratio in psychotic depression, suggests 
      a disruption to NMDAR composition could be present in the ACC in MDD; this could 
      lead to enhanced signalling via GluN2B-containing NMDARs and greater potential 
      for glutamate excitotoxicity in the ACC in MDD. These results support future 
      research into GluN2B antagonist-based treatments for MDD.
CI  - Copyright (c) 2023 Elsevier Ltd. All rights reserved.
FAU - Brown, Samara J
AU  - Brown SJ
AD  - School of Medical, Indigenous and Health Sciences and Molecular Horizons, 
      University of Wollongong, Wollongong, New South Wales, 2522, Australia; Illawarra 
      Health and Medical Research Institute, Wollongong, New South Wales, 2522, 
      Australia.
FAU - Brown, Amelia M
AU  - Brown AM
AD  - Schizophrenia Research Laboratory, Neuroscience Research Australia, Randwick, New 
      South Wales, 2031, Australia.
FAU - Purves-Tyson, Tertia D
AU  - Purves-Tyson TD
AD  - Schizophrenia Research Laboratory, Neuroscience Research Australia, Randwick, New 
      South Wales, 2031, Australia; Discipline of Psychiatry and Mental Health, Faculty 
      of Medicine, University of New South Wales, Sydney, New South Wales, 2031, 
      Australia.
FAU - Huang, Xu-Feng
AU  - Huang XF
AD  - School of Medical, Indigenous and Health Sciences and Molecular Horizons, 
      University of Wollongong, Wollongong, New South Wales, 2522, Australia; Illawarra 
      Health and Medical Research Institute, Wollongong, New South Wales, 2522, 
      Australia.
FAU - Shannon Weickert, Cynthia
AU  - Shannon Weickert C
AD  - Schizophrenia Research Laboratory, Neuroscience Research Australia, Randwick, New 
      South Wales, 2031, Australia; Discipline of Psychiatry and Mental Health, Faculty 
      of Medicine, University of New South Wales, Sydney, New South Wales, 2031, 
      Australia; Department of Neuroscience & Physiology, Upstate Medical University, 
      Syracuse, NY, 13210, USA.
FAU - Newell, Kelly A
AU  - Newell KA
AD  - School of Medical, Indigenous and Health Sciences and Molecular Horizons, 
      University of Wollongong, Wollongong, New South Wales, 2522, Australia; Illawarra 
      Health and Medical Research Institute, Wollongong, New South Wales, 2522, 
      Australia. Electronic address: knewell@uow.edu.au.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230216
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (RNA, Messenger)
RN  - 0 (NR2B NMDA receptor)
SB  - IM
MH  - Humans
MH  - Depression/psychology
MH  - *Depressive Disorder, Major/genetics
MH  - Gene Expression
MH  - Gyrus Cinguli/metabolism
MH  - *Receptors, N-Methyl-D-Aspartate/metabolism
MH  - RNA, Messenger/metabolism
OTO - NOTNLM
OT  - Anterior cingulate cortex
OT  - Depression
OT  - GRIN2B
OT  - Glutamate
OT  - NMDA
EDAT- 2023/02/28 06:00
MHDA- 2023/03/15 06:00
CRDT- 2023/02/27 18:28
PHST- 2022/07/07 00:00 [received]
PHST- 2023/01/16 00:00 [revised]
PHST- 2023/02/14 00:00 [accepted]
PHST- 2023/02/28 06:00 [pubmed]
PHST- 2023/03/15 06:00 [medline]
PHST- 2023/02/27 18:28 [entrez]
AID - S0022-3956(23)00076-6 [pii]
AID - 10.1016/j.jpsychires.2023.02.017 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2023 Apr;160:204-209. doi: 10.1016/j.jpsychires.2023.02.017. 
      Epub 2023 Feb 16.