PMID- 36848830 OWN - NLM STAT- MEDLINE DCOM- 20230321 LR - 20230322 IS - 1873-6750 (Electronic) IS - 0160-4120 (Linking) VI - 173 DP - 2023 Mar TI - Maternal plasma perfluoroalkyl substances concentrations in early pregnancy and cardiovascular development in offspring: A prospective cohort study. PG - 107748 LID - S0160-4120(23)00021-1 [pii] LID - 10.1016/j.envint.2023.107748 [doi] AB - BACKGROUND: High maternal plasma perfluoroalkyl substances (PFAS) concentrations has been associated with adverse birth outcomes, but data on early childhood cardiovascular health is limited. This study aimed to assess the potential association between maternal plasma PFAS concentrations during early pregnancy and cardiovascular development in offspring. MATERIAL AND METHODS: Cardiovascular development was assessed through blood pressure measurement, echocardiography and carotid ultrasound examinations among 957 children from the Shanghai Birth Cohort aged at 4 years old. Maternal plasma concentrations of PFAS were measured at mean gestational age of 14.4 (SD:1.8) weeks. The joint associations between PFAS mixture concentrations and cardiovascular parameters were analyzed using a Bayesian kernel machine regression (BKMR). The potential association of individual PFAS chemicals concentrations was explored using multiple linear regression. RESULTS: In BKMR analyses, carotid intima media thickness (cIMT), interventricular septum thickness in diastole and systole, posterior wall thicknesses in diastole and systole, and relative wall thickness were significantly lower when all log10-transformed PFAS were fixed at 75th percentile in comparison to at their 50th percentile[Estimated overall Risk:-0.31 (95%CI: -0.42, -0.20), -0.09 (95%CI: -0.11, -0.07), -0.21 (95%CI: -0.26, -0.16), -0.09 (95%CI: -0.11, -0.07), -0.07 (95%CI: -0.10, -0.04) and -0.005 (95%CI: -0.006, -0.004)].Furthermore, maternal plasma concentrations of individual short-chain PFAS was associated with a decrease in left ventricular wall thickness, intraventricular septum thickness and enlarged chamber volume, and long-chain with a decrease in cIMT. CONCLUSIONS: Our findings suggest that maternal plasma PFAS concentrations during early pregnancy was adversely associated with cardiovascular development in offspring, including thinner cardiac wall thickness and cIMT. CI - Copyright (c) 2023. Published by Elsevier Ltd. FAU - Wang, Jian AU - Wang J AD - Department of Pediatric Cardiology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Du, Bowen AU - Du B AD - Department of Pediatric Cardiology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Wu, Yujian AU - Wu Y AD - Department of Pediatric Cardiology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Li, Zhuoyan AU - Li Z AD - Department of Pediatric Cardiology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Wang, Hualin AU - Wang H AD - Department of Pediatric Cardiology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Niu, Yiwei AU - Niu Y AD - Department of Pediatric Cardiology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Ye, Yujiao AU - Ye Y AD - Department of Pediatric Cardiology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Chen, Qian AU - Chen Q AD - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Wang, Qianchuo AU - Wang Q AD - Department of Pediatric Cardiology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Wu, Yurong AU - Wu Y AD - Department of Pediatric Cardiology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Chen, Sun AU - Chen S AD - Department of Pediatric Cardiology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Zhang, Xi AU - Zhang X AD - Clinical Research Unit, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: zhangxi@xinhuamed.com.cn. FAU - Zhang, Jun AU - Zhang J AD - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: junjimzhang@sina.com. FAU - Sun, Kun AU - Sun K AD - Department of Pediatric Cardiology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: sunkun@xinhuamed.com.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20230112 PL - Netherlands TA - Environ Int JT - Environment international JID - 7807270 RN - 0 (Environmental Pollutants) RN - 0 (Fluorocarbons) RN - 0 (Alkanesulfonic Acids) SB - IM MH - Pregnancy MH - Child MH - Female MH - Humans MH - Child, Preschool MH - Aged MH - Infant MH - Maternal Exposure/adverse effects MH - Prospective Studies MH - Bayes Theorem MH - Carotid Intima-Media Thickness MH - *Environmental Pollutants/adverse effects MH - *Fluorocarbons/adverse effects MH - China MH - *Alkanesulfonic Acids OTO - NOTNLM OT - Birth cohort OT - Cardiovascular development OT - Perfluoroalkyl substances COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/02/28 06:00 MHDA- 2023/03/22 06:00 CRDT- 2023/02/27 18:38 PHST- 2022/07/14 00:00 [received] PHST- 2022/12/25 00:00 [revised] PHST- 2023/01/10 00:00 [accepted] PHST- 2023/02/28 06:00 [pubmed] PHST- 2023/03/22 06:00 [medline] PHST- 2023/02/27 18:38 [entrez] AID - S0160-4120(23)00021-1 [pii] AID - 10.1016/j.envint.2023.107748 [doi] PST - ppublish SO - Environ Int. 2023 Mar;173:107748. doi: 10.1016/j.envint.2023.107748. Epub 2023 Jan 12.