PMID- 36849850 OWN - NLM STAT- MEDLINE DCOM- 20230717 LR - 20230718 IS - 1434-9949 (Electronic) IS - 0770-3198 (Linking) VI - 42 IP - 8 DP - 2023 Aug TI - Knowledge mapping of biological disease-modifying anti-rheumatic drugs for axial spondyloarthritis: a bibliometric study. PG - 1999-2011 LID - 10.1007/s10067-023-06540-9 [doi] AB - Various biological disease-modifying anti-rheumatic drugs (bDMARDs) have been applied for treating axial spondyloarthritis (axSpA). However, there is a glaring absence of a bibliometric analysis on bDMARDs against axSpA. Articles related to use of bDMARDs in treating axSpA published from 2004 to 2022 were searched from the Web of Science Core Collection. VOS viewer 1.6.18 and CiteSpace 6.1.R2 were used to analyze and visualize the quantity and citations of publications, as well as to identify "research hotspots" and trends in this field. BibExcel version 1.0.0 and gCLUTO version 1.0 were used to build matrices for bi-clustering analysis. A total of 2546 articles referring to bDMARDs for treatment of axSpA were included in this bibliometric analysis. Overall, the number of publications has been increasing steadily annually. The USA (23.21%, 591 publications) ranked first with the largest output of papers, followed by Germany, and the Netherlands. Rheumazentrum Ruhrgebiet ranked first as the most frequent publisher (119 articles). Annals of the Rheumatic Diseases published the most documents (6.76%, 172 publications) in this field. The predominant hotspots have been "tuberculosis," "IL-17," and "quality of life" in the field until 2020. Since 2015, "biosimilar pharmaceuticals" has retained the popularity. Current research hotspots are "spinal radiographic progression," Janus kinase (JAK) inhibitors, and adverse events (AEs). Machine learning has become popular gradually. Globally, there has been a steady increase in the number of studies on bDMARDs use against axSpA. JAK inhibitors, spinal radiographic progression, biosimilar pharmaceuticals, and AEs are current research hotspots. Machine learning is emerging research hotspots and trends in this field. CI - (c) 2023. The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR). FAU - He, Qian AU - He Q AUID- ORCID: 0000-0002-3203-696X AD - Beijing University of Chinese Medicine, Beijing, China. AD - Traditional Chinese Medicine Department of Rheumatism, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing, 100029, China. FAU - Chen, Jia-Qi AU - Chen JQ AUID- ORCID: 0000-0002-1643-5450 AD - Beijing University of Chinese Medicine, Beijing, China. AD - Traditional Chinese Medicine Department of Rheumatism, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing, 100029, China. FAU - Yu, Xin-Bo AU - Yu XB AUID- ORCID: 0000-0003-2366-5147 AD - Beijing University of Chinese Medicine, Beijing, China. AD - Traditional Chinese Medicine Department of Rheumatism, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing, 100029, China. FAU - Liao, Jia-He AU - Liao JH AUID- ORCID: 0000-0001-7025-1022 AD - Beijing University of Chinese Medicine, Beijing, China. AD - Traditional Chinese Medicine Department of Rheumatism, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing, 100029, China. FAU - Huang, Zi-Wei AU - Huang ZW AUID- ORCID: 0000-0002-6907-5866 AD - Beijing University of Chinese Medicine, Beijing, China. AD - Traditional Chinese Medicine Department of Rheumatism, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing, 100029, China. FAU - Yang, Jian-Ying AU - Yang JY AUID- ORCID: 0000-0002-3009-8702 AD - Beijing University of Chinese Medicine, Beijing, China. AD - Traditional Chinese Medicine Department of Rheumatism, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing, 100029, China. FAU - Wu, Tzu-Hua AU - Wu TH AUID- ORCID: 0000-0002-3385-7997 AD - Beijing University of Chinese Medicine, Beijing, China. AD - Traditional Chinese Medicine Department of Rheumatism, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing, 100029, China. FAU - Song, Wei-Jiang AU - Song WJ AUID- ORCID: 0000-0002-2092-4775 AD - Traditional Chinese Medicine Department, Peking University Third Hospital, Beijing, China. FAU - Luo, Jing AU - Luo J AUID- ORCID: 0000-0002-2454-2168 AD - Traditional Chinese Medicine Department of Rheumatism, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing, 100029, China. luojinggg@sina.com. AD - Beijing Key Lab for Immune-Mediated Inflammatory Diseases, China-Japan Friendship Hospital, Beijing, China. luojinggg@sina.com. FAU - Tao, Qing-Wen AU - Tao QW AUID- ORCID: 0000-0002-9163-8426 AD - Traditional Chinese Medicine Department of Rheumatism, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing, 100029, China. taoqg1@sina.com. AD - Beijing Key Lab for Immune-Mediated Inflammatory Diseases, China-Japan Friendship Hospital, Beijing, China. taoqg1@sina.com. LA - eng GR - ZRJY2021-QM14/China-Japan Friendship Hospital/ GR - 2022-NHLHCRF-LX-02/National High Level Hospital Clinical Research Funding/ GR - 2020-4-40610/Capital's Funds for Health Improvement and Research/ GR - 2019-ZX-006/National Regional Traditional Chinese Medicine (Specialty) Treatment Center Project/ GR - 2011-ZDZK-001/National Key Clinical Specialty Building Project/ PT - Journal Article PT - Review DEP - 20230227 PL - Germany TA - Clin Rheumatol JT - Clinical rheumatology JID - 8211469 RN - 0 (Biosimilar Pharmaceuticals) RN - 0 (Antirheumatic Agents) RN - 0 (Janus Kinase Inhibitors) RN - 0 (Pharmaceutical Preparations) SB - IM MH - Humans MH - *Biosimilar Pharmaceuticals/therapeutic use MH - *Antirheumatic Agents/therapeutic use MH - *Axial Spondyloarthritis MH - Bibliometrics MH - *Janus Kinase Inhibitors MH - Pharmaceutical Preparations OTO - NOTNLM OT - Axial spondyloarthritis OT - Bibliometric analysis OT - Biological disease-modifying anti-rheumatic drugs OT - Hotspot OT - Knowledge mapping EDAT- 2023/03/01 06:00 MHDA- 2023/07/17 06:42 CRDT- 2023/02/28 00:30 PHST- 2022/11/07 00:00 [received] PHST- 2023/02/04 00:00 [accepted] PHST- 2023/01/14 00:00 [revised] PHST- 2023/07/17 06:42 [medline] PHST- 2023/03/01 06:00 [pubmed] PHST- 2023/02/28 00:30 [entrez] AID - 10.1007/s10067-023-06540-9 [pii] AID - 10.1007/s10067-023-06540-9 [doi] PST - ppublish SO - Clin Rheumatol. 2023 Aug;42(8):1999-2011. doi: 10.1007/s10067-023-06540-9. Epub 2023 Feb 27.