PMID- 3685080
OWN - NLM
STAT- MEDLINE
DCOM- 19880111
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 28
IP  - 3
DP  - 1987 Nov
TI  - A novel procedure for dissociating the anatomical bases of the behavioral effects 
      of amphetamine.
PG  - 423-6
AB  - A novel operative procedure is described in which the same cannula may be used to 
      administer drugs either to the caudate nucleus (CN) or to the nucleus accumbens 
      (NAcc) of the rat. Microinjections of amphetamine (10 or 20 micrograms) into the 
      CN produced a reliable and robust stereotyped response; when administered to the 
      NAcc of the same animal the higher dose increased locomotor activity. The 
      stereotypy following peripheral administration of amphetamine (5 mg/kg) was 
      antagonised by infusions of haloperidol (30 micrograms) into the CN but not into 
      the NAcc. Conversely, the locomotor activity following a lower dose of 
      amphetamine (1 mg/kg) was antagonised by infusions of haloperidol (5 micrograms) 
      into the NAcc but not into the CN. The results confirm earlier reports that 
      different anatomical structures mediate the behavioral effects of low and high 
      doses of amphetamine.
FAU - Towell, A
AU  - Towell A
AD  - Department of Psychology, City of London Polytechnic.
FAU - Willner, P
AU  - Willner P
FAU - Muscat, R
AU  - Muscat R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - CK833KGX7E (Amphetamine)
RN  - J6292F8L3D (Haloperidol)
SB  - IM
MH  - Amphetamine/*pharmacology
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Caudate Nucleus/drug effects/physiology
MH  - Haloperidol/pharmacology
MH  - Motor Activity/drug effects
MH  - Nucleus Accumbens/drug effects/physiology
MH  - Rats
MH  - Stereotyped Behavior/drug effects
EDAT- 1987/11/01 00:00
MHDA- 1987/11/01 00:01
CRDT- 1987/11/01 00:00
PHST- 1987/11/01 00:00 [pubmed]
PHST- 1987/11/01 00:01 [medline]
PHST- 1987/11/01 00:00 [entrez]
AID - 0091-3057(87)90465-5 [pii]
AID - 10.1016/0091-3057(87)90465-5 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1987 Nov;28(3):423-6. doi: 10.1016/0091-3057(87)90465-5.