PMID- 36851948
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230301
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 2
DP  - 2023 Feb
TI  - The Predictive Value of Donor Renal Functions, Graft Weight, Recipient Body Mass 
      Index, and Human Leucocyte Antigen Match Regarding Early Graft Functions.
PG  - e35438
LID - 10.7759/cureus.35438 [doi]
LID - e35438
AB  - Background and objective Graft performance is the most important postoperative 
      parameter for patients undergoing kidney transplantation (KTx). The renal 
      function of the donor is reported to be correlated with graft function after KTx. 
      The body mass index (BMI) is also one of the important parameters involved in the 
      prediction of graft function. The aim of this retrospective study was to examine 
      the relationship between early postoperative graft function in patients 
      undergoing KTx and donor cystatin C and estimated glomerular filtration rate 
      (e-GFR) levels, graft weight/recipient BMI (G/B) ratio, and human leukocyte 
      antigen (HLA) tissue compatibility. Materials and methods A total of 215 cases 
      (215 donors, 215 recipients) who underwent KTx at our center between January 2018 
      and December 2022 were included in the study. Patients' age, sex, BMI, 
      preoperative donor serum cystatin C and e-GFR levels, HLA tissue compatibility, 
      graft weights, and recipient creatinine levels were recorded one week 
      postoperatively. The Kolmogorov-Smirnov test and histogram plots were used to 
      analyze the conformity of the variables to the normal distribution and Spearman's 
      correlation test was used to analyze the relationship between variables. Results 
      A negative correlation was identified between recipient creatinine level and G/B 
      ratio and donor e-GFR (r = -0.256 and -0.137, respectively). Donor cystatin C 
      level showed a positive correlation with recipient creatinine level (r = 0.242). 
      No significant correlation was noted in terms of tissue matching rates (p = 
      0.616). Conclusion Although these three parameters are correlated with early 
      graft functions, the graft weight/recipient BMI ratio has the strongest 
      correlation.
CI  - Copyright (c) 2023, Acikgoz et al.
FAU - Acikgoz, Onur
AU  - Acikgoz O
AD  - Urology, Memorial Hizmet Hospital, Istanbul, TUR.
FAU - Akinci, Serkan
AU  - Akinci S
AD  - Urology, Memorial Hizmet Hospital, Istanbul, TUR.
LA  - eng
PT  - Journal Article
DEP - 20230225
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC9958525
OTO - NOTNLM
OT  - chronic kidney failure
OT  - kidney disease
OT  - kidney transplant recipients
OT  - live donor
OT  - * kidney transplantation
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/03/01 06:00
MHDA- 2023/03/01 06:01
PMCR- 2023/02/25
CRDT- 2023/02/28 02:07
PHST- 2023/02/24 00:00 [accepted]
PHST- 2023/02/28 02:07 [entrez]
PHST- 2023/03/01 06:00 [pubmed]
PHST- 2023/03/01 06:01 [medline]
PHST- 2023/02/25 00:00 [pmc-release]
AID - 10.7759/cureus.35438 [doi]
PST - epublish
SO  - Cureus. 2023 Feb 25;15(2):e35438. doi: 10.7759/cureus.35438. eCollection 2023 
      Feb.