PMID- 36854197
OWN - NLM
STAT- MEDLINE
DCOM- 20230322
LR  - 20230322
IS  - 2050-6120 (Electronic)
IS  - 2050-6120 (Linking)
VI  - 11
IP  - 2
DP  - 2023 Mar 21
TI  - Fluorescent carbon dots tailored iron oxide nano hybrid system forin vivooptical 
      imaging of liver fibrosis.
LID - 10.1088/2050-6120/acc009 [doi]
AB  - Hybrid nanoparticles are innovative invention of last decade designed to overcome 
      limitations of single-component nanoparticles by introducing multiple 
      functionalities through combining two or more different nanoparticles. In this 
      study, we are reporting development of magneto-fluorescent hybrid nanoparticles 
      by combining iron oxide and carbon nanoparticles to enablein vivofluorescence 
      imaging which also has all the required characteristic properties to use as 
      Magnetic Resonance Imaging (MRI) contrast agent. In order to achieve 
      dual-functional imaging, alginate and pullulan coated super paramagnetic iron 
      oxide nanoparticles (ASPION and PSPION) and Carbon dots (Cdts) were synthesised 
      separately. ASPIONs and PSPIONs were further chemically conjugated with Cdts and 
      developed dual-functional nanohybrid particles ASPION-Cdts and PSPION-Cdts. 
      Subsequently, evaluation of the materials for its size, functionalisation 
      efficiency, fluorescence and magnetic properties, biocompatibility and cellular 
      uptake efficiency has been carried out. Fluorescence imaging of liver fibrosis 
      was performedin vivoin rodent model of liver fibrosis using the two nanohybrids, 
      which is further confirmed by high fluorescence signal from the harvested liver.
CI  - (c) 2023 IOP Publishing Ltd.
FAU - Nazeer, Shaiju S
AU  - Nazeer SS
AUID- ORCID: 0000-0002-8409-1426
AD  - Department of Chemistry, Indian Institute of Space Sciences and Technology, 
      Thiruvananthapuram-695547, Kerala, India.
AD  - Division of Biophotonics and Imaging, Biomedical Technology Wing, Sree Chitra 
      Tirunal Institute for Medical Sciences &Technology, Poojappura, 
      Thiruvananthapuram-695012, Kerala, India.
FAU - Saraswathy, Ariya
AU  - Saraswathy A
AD  - Department of Physics, HHMSPBNSS College, Thiruvananthapuram-695040, Kerala, 
      India.
AD  - Division of Biophotonics and Imaging, Biomedical Technology Wing, Sree Chitra 
      Tirunal Institute for Medical Sciences &Technology, Poojappura, 
      Thiruvananthapuram-695012, Kerala, India.
FAU - Nimi, Nirmala
AU  - Nimi N
AD  - Division of Biophotonics and Imaging, Biomedical Technology Wing, Sree Chitra 
      Tirunal Institute for Medical Sciences &Technology, Poojappura, 
      Thiruvananthapuram-695012, Kerala, India.
FAU - Sarathkumar, Elangovan
AU  - Sarathkumar E
AUID- ORCID: 0000-0002-1221-8803
AD  - Division of Biophotonics and Imaging, Biomedical Technology Wing, Sree Chitra 
      Tirunal Institute for Medical Sciences &Technology, Poojappura, 
      Thiruvananthapuram-695012, Kerala, India.
FAU - Resmi, A N
AU  - Resmi AN
AD  - Division of Biophotonics and Imaging, Biomedical Technology Wing, Sree Chitra 
      Tirunal Institute for Medical Sciences &Technology, Poojappura, 
      Thiruvananthapuram-695012, Kerala, India.
FAU - Shenoy, Sachin J
AU  - Shenoy SJ
AD  - Division of In Vivo Models and Testing, Biomedical Technology Wing, Sree Chitra 
      Tirunal Institute for Medical Sciences &Technology, Poojappura, 
      Thiruvananthapuram-695012, Kerala, India.
FAU - Jayasree, Ramapurath S
AU  - Jayasree RS
AUID- ORCID: 0000-0001-6810-9879
AD  - Division of Biophotonics and Imaging, Biomedical Technology Wing, Sree Chitra 
      Tirunal Institute for Medical Sciences &Technology, Poojappura, 
      Thiruvananthapuram-695012, Kerala, India.
LA  - eng
PT  - Journal Article
DEP - 20230321
PL  - England
TA  - Methods Appl Fluoresc
JT  - Methods and applications in fluorescence
JID - 101608648
RN  - 1K09F3G675 (ferric oxide)
RN  - 7440-44-0 (Carbon)
RN  - 0 (Ferric Compounds)
RN  - 0 (Contrast Media)
SB  - IM
MH  - Humans
MH  - *Carbon/chemistry
MH  - Ferric Compounds/chemistry
MH  - Liver Cirrhosis/chemically induced/diagnostic imaging
MH  - *Nanoparticles/chemistry
MH  - Contrast Media/chemistry
OTO - NOTNLM
OT  - carbon dots
OT  - fluorescence imaging
OT  - hybrid nanoparticles
OT  - liver fibrosis
OT  - magnetic resonance imaging
OT  - magneto-optic material
OT  - multimodality imaging
EDAT- 2023/03/01 06:00
MHDA- 2023/03/23 06:00
CRDT- 2023/02/28 17:52
PHST- 2022/03/28 00:00 [received]
PHST- 2023/02/28 00:00 [accepted]
PHST- 2023/03/01 06:00 [pubmed]
PHST- 2023/03/23 06:00 [medline]
PHST- 2023/02/28 17:52 [entrez]
AID - 10.1088/2050-6120/acc009 [doi]
PST - epublish
SO  - Methods Appl Fluoresc. 2023 Mar 21;11(2). doi: 10.1088/2050-6120/acc009.