PMID- 36855263
OWN - NLM
STAT- MEDLINE
DCOM- 20230302
LR  - 20230302
IS  - 1525-6006 (Electronic)
IS  - 1064-1963 (Linking)
VI  - 45
IP  - 1
DP  - 2023 Dec 31
TI  - Paeonol improves renal and vascular angiotensin II type 1 receptor function via 
      inhibiting oxidative stress in spontaneously hypertensive rats.
PG  - 2182884
LID - 10.1080/10641963.2023.2182884 [doi]
AB  - BACKGROUND: Oxidative stress has been shown to play a critical role in the 
      pathogenesis of hypertension. Paeonol, a major phenolic component extracted from 
      Moutan Cortex, exerts a beneficial effect in preventing cardiovascular disease 
      via reducing oxidative stress. The present study investigated the protective 
      mechanism of paeonol against high blood pressure in spontaneous hypertension rats 
      (SHRs). METHODS: Wistar-Kyoto (WKY) rats and SHRs received vehicle or peaonol in 
      the drinking water for 5 weeks. Blood pressure was measured by tail-cuff 
      plethysmography and oxidative stress in kidney and vascular tissue was examined 
      by enzyme-linked immunosorbed assay. The functions of angiotensin II type 1 
      receptors (AT(1)R) in the kidney and mesenteric artery were measured by 
      natriuresis and vasoconstrictor response, respectively. RESULTS: Compared with 
      vehicle-treated WKY rats, vehicle-treated SHRs exhibited higher blood pressure, 
      increased oxidative stress, accompanied by exaggerated diuretic and natriuretic 
      responses to candesartan (AT(1) receptor antagonist) and vasoconstrictor 
      responses to angiotensin II (Ang II). Moreover, SHRs had higher ACE and AT(1)R in 
      the kidney and mesenteric artery, and higher Ang II and lower renin levels. 
      Interestingly, paeonol treatment reduced the candesartan-induced increase in 
      diuresis and natriuresis and vasoconstrictor responses to Ang II, and lowered 
      blood pressure in SHRs, accompanied by reducing AT(1)R protein expression in the 
      kidney and mesenteric artery of SHR, and Ang II levels in plasma and increasing 
      renin levels in renal cortex. In addition, these changes were associated with 
      reducing oxidative stress. CONCLUSIONS: The present study suggests that paeonol 
      improves renal and vascular AT(1)R functions by inhibition of oxidative stress, 
      thus lowering blood pressure in SHRs.
FAU - Wu, Tingchun
AU  - Wu T
AD  - Guangzhou University of Chinese Medicine, Guangzhou, China.
AD  - Department of Cardiology, The Second Affiliated Hospital of Guizhou University of 
      Chinese Medicine, Guiyang, China.
FAU - Zheng, Yuhua
AU  - Zheng Y
AD  - Department of Cardiology, The Second Affiliated Hospital of Guizhou University of 
      Chinese Medicine, Guiyang, China.
FAU - Huang, Qianqian
AU  - Huang Q
AD  - Department of Cardiology, The Second Affiliated Hospital of Guizhou University of 
      Chinese Medicine, Guiyang, China.
FAU - Tian, Shui
AU  - Tian S
AD  - Department of Cardiology, Guizhou Provincial People's Hospital, Guiyang, China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Exp Hypertens
JT  - Clinical and experimental hypertension (New York, N.Y. : 1993)
JID - 9305929
RN  - S8Q36MD2XX (candesartan)
RN  - 3R834EPI82 (paeonol)
RN  - EC 3.4.23.15 (Renin)
RN  - 0 (Receptor, Angiotensin, Type 1)
RN  - 11128-99-7 (Angiotensin II)
RN  - 0 (Vasoconstrictor Agents)
SB  - IM
MH  - Rats
MH  - Animals
MH  - Rats, Inbred WKY
MH  - Rats, Inbred SHR
MH  - *Renin
MH  - Receptor, Angiotensin, Type 1
MH  - Angiotensin II
MH  - Kidney
MH  - *Hypertension/drug therapy
MH  - Oxidative Stress
MH  - Vasoconstrictor Agents
OTO - NOTNLM
OT  - Paeonol
OT  - angiotensin II type 1 receptor
OT  - hypertension
OT  - kidney
OT  - mesenteric artery
OT  - oxidative stress
EDAT- 2023/03/02 06:00
MHDA- 2023/03/03 06:00
CRDT- 2023/03/01 01:01
PHST- 2023/03/01 01:01 [entrez]
PHST- 2023/03/02 06:00 [pubmed]
PHST- 2023/03/03 06:00 [medline]
AID - 10.1080/10641963.2023.2182884 [doi]
PST - ppublish
SO  - Clin Exp Hypertens. 2023 Dec 31;45(1):2182884. doi: 
      10.1080/10641963.2023.2182884.