PMID- 36855809
OWN - NLM
STAT- MEDLINE
DCOM- 20230510
LR  - 20230510
IS  - 1613-4133 (Electronic)
IS  - 1613-4125 (Linking)
VI  - 67
IP  - 9
DP  - 2023 May
TI  - The Effect of Inulin-Type Fructans on Plasma Trimethylamine N-Oxide Levels in 
      Peritoneal Dialysis Patients: A Randomized Crossover Trial.
PG  - e2200531
LID - 10.1002/mnfr.202200531 [doi]
AB  - SCOPE: Trimethylamine N-oxide (TMAO), an important proatherogenic uremic toxin, 
      is oxidized by hepatic-flavin monooxygenases from gut microbiome-generated 
      trimethylamine (TMA). The present study aims to explore whether manipulating the 
      gut microbiota by inulin-type fructans (ITFs) can reduce circulating TMAO levels 
      in peritoneal dialysis patients. METHODS AND RESULTS: This is a randomized, 
      double-blind, placebo-controlled, crossover trial with 10 g day(-1) ITFs 
      intervention for 3 months in continuous ambulatory peritoneal dialysis patients. 
      The gut microbiome is measured, and TMA-producing gene clusters are annotated 
      using shotgun metagenomic sequencing. Fecal and plasma TMA, plasma TMAO, and 
      daily urine excretion and dialysis removal of TMAO are measured. Finally, 22 
      participants complete the trial. The daily intake of macronutrients and TMAO 
      precursors is comparable during the prebiotics, washout, and placebo 
      interventions. The ITFs intervention increases the Firmicutes/Bacteroidetes (F/B) 
      ratio (p = 0.049) of gut microbiome. However, no significant influences are 
      observed on fecal TMA content, circulating TMAO levels, or TMA-producing gene 
      clusters, including choline TMA-lyase (CutC/D), carnitine monooxygenase (CntA/B), 
      and betaine reductase (GrdH). CONCLUSIONS: Intervention with 10 g day(-1) of ITFs 
      for 3 months is not sufficient to reduce plasma TMAO levels in peritoneal 
      dialysis patients, but it improves the gut microbiome composition.
CI  - (c) 2023 Wiley-VCH GmbH.
FAU - Xiong, Qianqian
AU  - Xiong Q
AD  - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition 
      and Safety, School of Public Health, Tongji Medical College, Huazhong University 
      of Science and Technology, Wuhan, Hubei, 430030, China.
FAU - Li, Li
AU  - Li L
AD  - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition 
      and Safety, School of Public Health, Tongji Medical College, Huazhong University 
      of Science and Technology, Wuhan, Hubei, 430030, China.
FAU - Xiao, Yonghua
AU  - Xiao Y
AD  - Institute of Food and Environmental Health, Wuhan Centers for Disease Control and 
      Prevention, Wuhan, Hubei, 430024, China.
FAU - He, Shuiqing
AU  - He S
AD  - Hunan Institute for Tuberculosis Control, Hunan Chest Hospital, Department of 
      Nutrition, Changsha, Hunan, 410000, China.
FAU - Zhao, Jing
AU  - Zhao J
AD  - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition 
      and Safety, School of Public Health, Tongji Medical College, Huazhong University 
      of Science and Technology, Wuhan, Hubei, 430030, China.
FAU - Lin, Xuechun
AU  - Lin X
AD  - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition 
      and Safety, School of Public Health, Tongji Medical College, Huazhong University 
      of Science and Technology, Wuhan, Hubei, 430030, China.
FAU - He, Yuqin
AU  - He Y
AD  - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition 
      and Safety, School of Public Health, Tongji Medical College, Huazhong University 
      of Science and Technology, Wuhan, Hubei, 430030, China.
FAU - Wang, Jinxue
AU  - Wang J
AD  - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition 
      and Safety, School of Public Health, Tongji Medical College, Huazhong University 
      of Science and Technology, Wuhan, Hubei, 430030, China.
FAU - Guo, Xiaolei
AU  - Guo X
AD  - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition 
      and Safety, School of Public Health, Tongji Medical College, Huazhong University 
      of Science and Technology, Wuhan, Hubei, 430030, China.
FAU - Liang, Wangqun
AU  - Liang W
AD  - Division of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, Hubei, 430030, China.
FAU - Zuo, Xuezhi
AU  - Zuo X
AD  - Department of Clinical Nutrition, Tongji Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
FAU - Ying, Chenjiang
AU  - Ying C
AUID- ORCID: 0000-0003-4813-5951
AD  - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition 
      and Safety, School of Public Health, Tongji Medical College, Huazhong University 
      of Science and Technology, Wuhan, Hubei, 430030, China.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20230317
PL  - Germany
TA  - Mol Nutr Food Res
JT  - Molecular nutrition & food research
JID - 101231818
RN  - FLD0K1SJ1A (trimethyloxamine)
RN  - 9005-80-5 (Inulin)
RN  - 0 (Fructans)
RN  - 0 (Methylamines)
RN  - N91BDP6H0X (Choline)
RN  - LHH7G8O305 (trimethylamine)
SB  - IM
MH  - Humans
MH  - *Inulin/pharmacology
MH  - Fructans
MH  - Cross-Over Studies
MH  - Methylamines
MH  - Choline
MH  - *Peritoneal Dialysis
OTO - NOTNLM
OT  - gut microbiome
OT  - inulin-type fructans
OT  - peritoneal dialysis
OT  - prebiotics
OT  - trimethylamine N-oxide
EDAT- 2023/03/02 06:00
MHDA- 2023/05/10 06:42
CRDT- 2023/03/01 02:30
PHST- 2023/02/12 00:00 [revised]
PHST- 2022/08/10 00:00 [received]
PHST- 2023/05/10 06:42 [medline]
PHST- 2023/03/02 06:00 [pubmed]
PHST- 2023/03/01 02:30 [entrez]
AID - 10.1002/mnfr.202200531 [doi]
PST - ppublish
SO  - Mol Nutr Food Res. 2023 May;67(9):e2200531. doi: 10.1002/mnfr.202200531. Epub 
      2023 Mar 17.