PMID- 36855973
OWN - NLM
STAT- MEDLINE
DCOM- 20230302
LR  - 20230302
IS  - 1314-2143 (Electronic)
IS  - 0204-8043 (Linking)
VI  - 65
IP  - 1
DP  - 2023 Feb 28
TI  - Does oxidative status affect serum sclerostin levels in patients with type 2 
      diabetes mellitus?
PG  - 46-52
LID - 10.3897/folmed.65.e72953 [doi]
AB  - INTRODUCTION: Sclerostin is a glycoprotein known as a negative regulator of bone 
      formation, predominantly expressed by mature  osteocytes. There is no causative 
      evidence information on the role of sclerostin in the pathogenesis of type 2 
      diabetes mellitus (T2DM) in humans. AIM: This study aimed to investigate the 
      relationship between serum sclerostin levels and oxidative status and biochemical 
      parameters in T2DM patients and healthy people. MATERIALS AND METHODS: This 
      cross-sectional study, conducted in a clinical trial center, included 45 subjects 
      with T2DM and 45 subjects as controls. RESULTS: Serum sclerostin, total oxidative 
      status (TOS), albumin, and ferritin levels were significantly higher in T2DM 
      patients than in the control group (p<0.05). Total antioxidant status (TAS) was 
      significantly higher in the control group (p<0.05). There was a weak positive 
      correlation between sclerostin and TOS (r=0.23, p=0.03) and a weak negative 
      correlation between sclerostin and TAS (r=-0.28, p=0.03). CONCLUSIONS: We have 
      demonstrated that serum sclerostin levels increase in patients with T2DM and that 
      the increased sclerostin levels are associated with oxidative stress.
CI  - This is an open access article distributed under the terms of the CC0 Public 
      Domain Dedication.
FAU - Sabancilar, Ilhan
AU  - Sabancilar I
AD  - Dicle University, Diyarbakir, Turkiye.
FAU - Unsal, Velid
AU  - Unsal V
AUID- ORCID: 0000-0003-1415-0563
AD  - Mardin Artuklu University, Mardin, Turkiye.
FAU - Demir, Fidel
AU  - Demir F
AD  - Silopi State Hospital, Sirnak, Turkiye.
FAU - Toprak, Gulten
AU  - Toprak G
AD  - Dicle University, Diyarbakir, Turkiye.
FAU - Pekkolay, Zafer
AU  - Pekkolay Z
AD  - Dicle University, Diyarbakir, Turkiye.
LA  - eng
PT  - Journal Article
PL  - Bulgaria
TA  - Folia Med (Plovdiv)
JT  - Folia medica
JID - 2984761R
RN  - 0 (Antioxidants)
SB  - IM
MH  - Humans
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2
MH  - Antioxidants
MH  - Oxidative Stress
MH  - Patients
OTO - NOTNLM
OT  - TAS
OT  - TOS
OT  - sclerostin
OT  - type 2 diabetes mellitus
EDAT- 2023/03/02 06:00
MHDA- 2023/03/03 06:00
CRDT- 2023/03/01 04:13
PHST- 2021/08/12 00:00 [received]
PHST- 2022/01/04 00:00 [accepted]
PHST- 2023/03/01 04:13 [entrez]
PHST- 2023/03/02 06:00 [pubmed]
PHST- 2023/03/03 06:00 [medline]
AID - 10.3897/folmed.65.e72953 [doi]
PST - ppublish
SO  - Folia Med (Plovdiv). 2023 Feb 28;65(1):46-52. doi: 10.3897/folmed.65.e72953.